[International Journal of Oral Science] Researchers explored a neural crest-like progenitor niche in bone marrow MSCs with high neurogenic and proliferative capacity by single-cell transcriptomics.

[ACS Nano] Scientists developed a hybrid gelled nanovesicle, Hy-gNVs@chol, through chitosan-based protein enrichment and functional membrane replacement, enabling efficient concentration of MSC components to form gel nanoparticles while conferring inflammation-targeting capability.

[Biomaterials Advances] As part of an effort to eliminate synthetic osteogenic compounds, the authors characterized the metabolic adaptations of MSC to chemical-free nanovibration-induced osteodifferentiation.

[Autophagy] Researchers investigated the therapeutic effects of apoptotic bodies derived from human umbilical cord MSCs on cardiac recovery in a porcine model of myocardial infarction.

[Cellular & Molecular Biology Letters] This study established METTL3 as a critical regulator of the immunosuppressive capacity of MSCs, mediated through inducible nitric oxide synthase expression.

[Journal of Biomaterials Applications] A synergistic bio-electroactive platform was established to specifically induce neuronal differentiation from bone marrow MSCs by coupling spatially oriented, conductive polycaprolactone/reduced graphene oxide nanofibrous scaffolds with exogenous electrical stimulation.

[Bioactive Materials] Investigators developed an innovative universal chimeric antigen receptor (CAR) nanoplatform by engineering MSCs with CAR and integrating them with multifunctional hybrid nanoparticles.

[Journal of Nanobiotechnology] MSCs were delivered into in vivo bone defects with a handheld electrospinning device as an improved cell seeding strategy.

[Stem Cell Research & Therapy] High-dose fresh autologous adipose tissue-MSCs were intravenously administered to 10 female patients with secondary progressive multiple sclerosis in two doses, seven days apart.

[Stem Cell Research & Therapy] Scientists focused on the activation mechanisms of Nrf2 and its clinical and preclinical inducers, with particular emphasis on the mechanistic insights and therapeutic applications of natural flavonoids and MSCs in the prevention or treatment of inflammatory diseases.

[Stem Cell Reviews and Reports] Recent advances in regenerative medicine have introduced promising biological strategies, particularly mesenchymal stem cells, exosomes, and bioengineered tissue scaffolds, for functional joint restoration.

[Singapore-MIT Alliance for Research and Technology (SMART)O)] An interdisciplinary research group, in collaboration with the Massachusetts Institute of Technology and the National University of Singapore, has developed a first-of-its-kind rapid, non-destructive method to monitor iron flux in MSCs, which can provide insights within a minute into the cell’s ability to grow cartilage tissue for cartilage repair.