[Nature Reviews Endocrinology] The authors summarize the interconnected causes of obesity and lymphatic dysfunction with a particular focus on delineating the underappreciated yet fundamental crosstalk between the lymphatic network and white and brown adipose tissues.

[Science Translational Medicine] Using dynamic contrast–enhanced magnetic resonance imaging, researchers showed that blood-brain barrier disruption can be detected years after the retirement of combat and collision sports athletes from their respective sports.

[Nature Communications] Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, scientists identified mechanosensitive Piezo1 upregulation in endothelial cells as a hallmark of fibrotic progression.

[Advanced Science] The authors established that endothelial G protein-coupled receptor 68 (GPR68) is a critical mediator of the inflammatory-remodeling program essential for arteriogenesis.

[Iscience] In low-shear stress-treated human aortic endothelial cells (HAECs), Interferon regulatory factor 6 (IRF6) was also highly expressed. Inhibition of IRF6 reduces the expression of pro-inflammatory adhesion molecules and the adhesion of THP-1 cells to HAECs.

[Proceedings of the National Academy of Sciences of the United States of America] Given the intimate interactions between leukocytes and endothelial cells in inflammation resolution, researchers investigated whether unique bioactive molecules carrying pro-resolution properties are biosynthesized by human neutrophils coincubated with activated vascular endothelial cells.

[MSU News Service] Assistant professor Dr. Emma Loveday of the College of Agriculture’s Department of Microbiology and Cell Biology is the lead investigator on a $1.9 million grant awarded by the US Department of Agriculture to study highly pathogenic avian influenza, more commonly known as “bird flu.

[Nature Reviews Immunology] The authors highlight shared features, such as effector functions and stemness properties, of effective CD8⁺ T cell responses against diverse viruses such as SARS-CoV-2 and HIV.

[Nature Microbiology] Scientists showed that LRP8 expression increases yellow fever virus (YFV) infection in cell lines by promoting entry. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes.

[Nature Immunology] Researchers provided a framework that features epigenetic programming of myeloid and CD4+ T cells as a major mechanism that promotes decay of the HIV reservoir.

[Nature Communications] The authors reported the development of a mouse-adapted Yezo virus strain that causes lethal infection in immunocompetent mice, mirroring key clinical features of human infection, including thrombocytopenia, leukopenia, and severe liver injury.

[npj Viruses] The authors discuss the pathogenesis of venezuelan equine encephalitis virus (VEEV) and the current state of VEEV vaccines that are in clinical development.