[Nature Immunology] Scientists suggested a role for CD4+ T cells in enhancing immune checkpoint blocker-mediated responses in people with melanoma and mismatch-repair-deficient colon cancers that have downregulated MHC class I.

[Cell Death & Disease] Researchers investigated naive and memory CD8 T cells from healthy donors stimulated in vitro in the presence of clinically relevant JAK inhibitors targeting JAK1, JAK1/2, or JAK1/3.

[Communications Biology] Scientists discuss crosstalk between glycosylation, ubiquitination, and phosphorylation, metabolic regulation of uridine diphosphate-N-acetylglucosamine flux, and pathogen- or tumor-driven glycosylation reprogramming, highlighting glycosylation enzymes as potential immunomodulatory targets.

[Signal Transduction and Targeted Therapy] Scientists explored the immunogenic potential of multiple transforming growth factor beta (TGFβ)-derived epitopes and assessed the clinical relevance of TGFβ-specific T cells in PDAC patients.

[Nature Communications] Using pancreatic islet transplantation in NOD mice, investigators showed that induction of tolerance to a CD4⁺ T cell hybrid insulin peptide neoepitope reprograms the fate of antigen-specific CD8⁺ T cells within the grafts.

[Nature Communications] Researchers revealed a pivotal role of Prolyl 3-hydroxylase 1 in pancreatic ductal adenocarcinoma using transcriptome sequencing, proteomic analyses and engineered mouse model.

[Cell Death & Disease] To validate the feasibility of transdifferentiation in epithelial malignancies such as PDAC, scientists applied an adipogenesis protocol in seven human PDAC cell lines and distinguished AsPC-1 with intensified adipocyte features

[Chinese Medical Journal] Researchers elucidated the mechanism of Rhein in pancreatitis-associated intestinal injury, with a focus on intestinal macrophage polarization and peroxisome proliferator-activated receptor γ (PPARγ) signaling.

[Scientific Reports] Investigators explored the effects of resveratrol on pancreatic cancer cell proliferation, migration, invasion, and epithelial–mesenchymal transition, with a particular focus on the role of inhibitor of growth family member 5 (ING5).

[Cancer Letters] The authors highlight pancreatic cancer-specific mechanisms underpinning each hallmark of cancer to provide a comprehensive review of the current state of knowledge around this complex disease, with the aim of aiding understanding and facilitating more meaningful research avenues.

[Silexion Therapeutics, Corp. (Globe Newswire)] Silexion Therapeutics, Corp. announced that it has received formal approval from the Israeli Ministry of Health to initiate its Phase II/III clinical trial evaluating SIL204 for the treatment of locally advanced pancreatic cancer, following positive preclinical results that demonstrated significant anti-tumor activity in multiple models alongside successful completion of toxicology studies.

[Nature Reviews Endocrinology] The authors summarize the interconnected causes of obesity and lymphatic dysfunction with a particular focus on delineating the underappreciated yet fundamental crosstalk between the lymphatic network and white and brown adipose tissues.