[The University of Edinburgh] Researchers at the University of Edinburgh’s Institute of Genetics and Cancer are launching a £1.5 million Cancer Research UK-funded study to find a way to ‘trick’ bowel cancer cells.

[iScience] Using colorectal cancer cell lines, organoids, and xenograft models, investigators showed that Cya-Gly-Fer (CGF) significantly inhibits tumor growth and metastasis.

[Cell Death Discovery] Investigators demonstrated that α-helical proteins of bacterial origin can form tumoricidal complexes with sodium oleate.

[Oncogene] The authors used the azoxymethane/dextran sulfate sodium model to induce colorectal cancer and investigate the role of carbohydrate response element-binding proteinin colorectal carcinogenesis in vivo.

[British Journal of Cancer] Scientists investigated the hypothesis that Notch signaling, through RBP-J, directly transcriptionally regulates SMAD2 and SMAD3, thereby modulating transforming growth factor-beta (TGF-β) pathway output.

[Cell Death & Disease] Stable OTUB2 overexpression and knockdown cells were cocultured with M0 macrophages to study tumor-associated macrophages polarization.

[Nature] Investigators showed that metastasis-associated oncofetal cell states already emerge at the earliest stages of colorectal cancer, concurrent with invasive front formation.

[International Journal of Molecular Medicine] Scientists highlight the gastric cancer‑specific mechanisms, controversial scientific issues and latest clinical translation progress of RNA‑binding proteins (RBPs) and propose personalized treatment strategies based on the molecular characteristics of RBPs.

[Cell Death Discovery] Through pulse selection of the parental cells, researchers established docetaxel- and cabazitaxel-resistant CRPC cell models and integrated different omic approaches, including transcriptomics and proteomics, to determine the molecular signatures underlying taxane resistance.

[British Journal of Cancer] Scientists investigated how SUMOylation regulates EphB4 localisation, stability and function in prostate cancer (PCa). They reported that SUMOylation at K616 stabilizes EphB4, promotes MYC signaling, and PCa cell migration.

[Cell Death & Differentiation] Scientists elucidated the role of Wnt pathway activation in mediating resistance to androgen receptor (AR) signaling inhibition and identified a robust molecular signature for predicting treatment outcomes.

[Cancer Gene Therapy] Researchers utilized a tissue microarray and collected tissues from prostate cancer (PCa) patients to detect Wilms’ tumor 1-associating protein (WTAP) expression, and found that WTAP is upregulated in PCa.