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Kerri Chen
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Proximity between LAG-3 and the T Cell Receptor Guides Suppression of T Cell Activation and Autoimmunity
[Cell] To exploit LAG-3’s proximity to T cell receptor (TCR) and maximize LAG-3-dependent T cell suppression, scientists developed an Fc-attenuated LAG-3/TCR inhibitory bispecific antibody to bypass the requirement of cognate peptide-MHC class II.
Chemosensor Receptors Are Lipid-Detecting Regulators of Macrophage Function in Cancer
[Nature Immunology] Researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages. Their study confirmed the function of known regulators in tumor associated macrophage responses and revealed new insights into the behavior of these cells.
A Genome-Wide Association Study Integrated With Single-Cell and Bulk Profiles Uncovers Susceptibility Genes for Nasopharyngeal Carcinoma Involved in Tumorigenesis Via Regulation of T Cells
[Genome Biology] Scientists performed in-depth bioinformatic analysis and functional experiments for EOMES, finding that the nasopharyngeal carcinoma-risk alleles of four functional SNPs upregulate EOMES expression by promoting the activity of regulatory elements in T cells.