Makenna Cameron

[Parse Biosciences] Parse Biosciences and Nomic Bio announced their partnership to generate Cascade, a 100 Million cell foundational dataset to understand the human immune response.

[Forlong Biotechnology] Forlong Biotechnology announced that the first patient has been dosed in a Phase I study of subcutaneous FL115, an engineered IL-15/IL-15Rα-Fbody^® fusion protein designed to stimulate NK cells and T cells, in patients with advanced solid tumors in Australia.

[Nature Medicine] Investigators used single-cell RNA and T cell receptor sequencing, longitudinal immune profiling, and imaging flow cytometry to identify long-lived intrathecal clonotypes and antigen-presenting cell–T cell complexes displaying features of immunological synapse formation, consistent with intrathecal antigen presentation.

[Nature] Scientists generated whole-genome and single-cell RNA sequencing from more than 5.4 million blood-derived cells across 1,925 individuals in two cohorts, and perform meta-analysis to characterize the impact of variation in more than 1.7 million tandem repeats loci on immune cell type-specific gene expression.

[Nature] The authors reported that neutrophils from patients with systemic lupus erythematosus, unlike neutrophils from healthy donors or patients with rheumatoid arthritis, contain many aberrantly spliced gene transcripts.

[Signal Transduction and Targeted Therapy] Scientists integrated single-cell profiles from peripheral blood and kidney graft samples from patients with chronic antibody-mediated rejection or stable allograft function and healthy controls, bulk transcriptomic datasets, spectral flow cytometry, multiplex immunofluorescence, high-resolution spatial transcriptomics, and a large blood immune reference spanning autoimmune and inflammatory diseases.