Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Subscribe|Follow Us On

THY1+ Cancer Stem Cells Drive Metastasis through a Pseudohypoxic State Shaped by Neutrophil-Derived Mitochondria

February 18, 2026

[Nature Cell Biology] Through multi-omics, pan-cancer analysis, and multiple tumour-bearing models, investigators identified THY1^⁺ CSCs as the key drivers of metastasis and uncover a previously unrecognized ‘pseudohypoxic’ state as a central regulatory factor.

DSG2+ Cancer Stem Cells Co-Located with FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non-Small Cell Lung Cancer

February 18, 2026

[Advanced Science] The authors integrated single-cell RNA sequencing with spatial transcriptomics to systematically define CSC-associated phenotype in NSCLC. Weighted gene co-expression network analysis identified a 127-gene CSC signature enriched for stemness-related pathways.

CircRSU1 Activates the hnRNPA1/HIF-1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

February 18, 2026

[Advanced Science] Researchers identified circRNAs with key roles in promoting hepatocellular carcinoma (HCC) malignancy and stemness properties. Through circRNA profiling comparison in HCC patients and functional screening in HCC cells, circRSU1 emerges as the top candidate.

KIF20A Inhibits TRIM21-Dependent Ubiquitination of DHX9 to Boost SOX2 Stability, Enhancing OSCC Stemness, and Ferroptosis Resistance

February 18, 2026

[Cell Death & Disease] Mechanistic investigations revealed that KIF20A regulates DHX9 nucleocytoplasmic distribution and inhibits TRIM21-mediated K48-linked polyubiquitination at DHX9-K755, thereby preventing its proteasomal degradation and enhancing protein stability.

KDM6A Alternative Splicing Induced by 25(OH)D Inhibits Breast Cancer Cell Stemness through Repressing TRAP1 Transcription

February 18, 2026

[Oncogene] Investigators revealed for the first time that 25-Hydroxyvitamin D (25(OH)D) exerts antitumor effects by promoting exon 13 skipping of KDM6A, which suppresses the proliferation and stemness of breast cancer cells and lacks H3K27 demethylase activity.

KCTD15 Enhances Stem Cell-Like Properties and Promotes Triple-Negative Breast Cancer Progression through KLF4/β-Catenin Signaling

February 18, 2026

[FASEB Journal] Scientists elucidated the functional role of the potassium channel tetramerization domain 15 (KCTD15) in triple-negative breast cancer progression, providing mechanistic insights into its potential as a therapeutic target for this challenging disease.

Synthetic Lethality and DNA Damage Response Targeting in Cancer Stem Cells: A Comprehensive Review

February 18, 2026

[Discover Oncology] The authors synthesize current preclinical and clinical advancements in targeting CSCs via DNA damage response inhibitors, including PARP, ATR, ATM, and DNA-PKcs inhibitors, as well as emerging synthetic lethality targets.

US FDA Approves Novocure’s Optune Pax® for the Treatment of Locally Advanced Pancreatic Cancer

February 18, 2026

[Novocure] Novocure announced that the US FDA approved Optune Pax^® for the treatment of adult patients with locally advanced pancreatic cancer concomitant with gemcitabine and nab-paclitaxel.

Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis

February 12, 2026

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.

Ebastine Targets HER2/HER3 Signaling and Cancer Stem Cell Traits to Overcome Trastuzumab Resistance in HER2‑Positive Breast Cancer

February 12, 2026

[International Journal of Molecular Medicine] Scientists evaluated the therapeutic potential of ebastine as a repurposing candidate to overcome trastuzumab resistance by targeting HER2 signaling and CSC‑associated phenotypes in HER2‑positive breast cancer cells.

OSBPL2-Mediated Lipid Metabolism Alteration Governs Lung Cancer Stem Cells Properties

February 12, 2026

[Stem Cell Research & Therapy] Investigators observed that oxysterol-binding protein-like 2 (OSBPL2) reduced cholesterol content by HPLC-MS. It inhibited the accumulation of lipid droplets in lung cancer.

SHH Pathway Inhibition and Astrocyte Co-Culture Induce Distinct Responses in Glioblastoma and Cancer Stem Cells

February 12, 2026

[Scientific Reports] The authors investigated how SHH pathway inhibition affects both bulk glioblastoma (GBM) cells and CD133+ GBM cells, with particular emphasis on the influence of astrocyte co-culture, which more closely mimics the brain tumor microenvironment.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.