Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Subscribe|Follow Us On

The Josep Carreras Institute and the Chinese Institute of Hematology and Blood Diseases Hospital join forces to advance research in blood cancers

April 1, 2026

[IJC] The Josep Carreras Leukemia Research Institute (IJC) has welcomed a high-level delegation from the Institute of Hematology & Blood Diseases Hospital. Collaborative efforts will address critical challenges in the field, including the biology of blood cancer stem cells, mechanisms of therapeutic resistance, and the development of next-generation immunotherapies.

Loss of ABCA3 Disrupts Lipid Balance and Leads to AMPK-Dependent Suppression of SREBP1 in Glioblastoma Stem Cells

April 1, 2026

[Oncogene] Scientists demonstrate that the ATP-binding cassette transporter A3 (ABCA3) maintains lipid metabolic balance in glioblastoma stem cells. Knocking down ABCA3 significantly reduces cell growth, self-renewal, viability, and tumor growth after intracranial implantation.

CAFs-Derived LAM332 Promotes CTCs Formation and Survival via ITGA3 and Contributes to the Metastasis of Pancreatic Ductal Adenocarcinoma

April 1, 2026

[Cell Death & Disease] Researchers identified Integrin subunit alpha-3 (ITGA3) as a key driver of circulating tumor cell generation and metastatic progression in pancreatic ductal adenocarcinoma. ITGA3 promotes epithelial–mesenchymal transition, enhances matrix metalloproteinase expression, and facilitates tumor cell detachment.

Therapeutic Efficacy of Cancer Stem Cell-Based Vaccine in Colorectal Murine Model: Reduced Tumor Growth and Prolonged Survival

April 1, 2026

[BMC Cancer] The authors develooped a therapeutic colorectal cancer stem cell-based vaccine to explore whether this vaccination could inhibit the formation and prolong survival rates in a mouse model of colorectal cancer.

POU1F1 Induces Cancer Stem Cell-Like Traits in Breast Cancer Cells by IL-6/JAK2/STAT3 Activation and Enrichment of ALDH

April 1, 2026

[NPJ Breast Cancer] Using POU1F1-overexpressing and knock-down breast cancer cell lines, as well as immunodeficient mouse models, the data demonstrated that POU1F1 induces a breast cancer stem cell-like phenotype in breast tumor cells by deregulating markers such as CD24, CD44, CD133, and ALDH.

Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells

April 1, 2026

[ACS Chemical Biology] Investigators established the first proof of concept for light-controlled autophagy inhibition and provide a blueprint for spatiotemporally confined anticancer therapies based on photopharmacological modulation of cancer stem cells.

Inhibition of the Cancer Stem Cell Immune Checkpoint SOAT1 Suppresses Regulatory T Cell Functions through a Trans-Cellular 20(S)-Hydroxycholesterol-GPR132 Pathway in Mice

April 1, 2026

[Nature Communications] Researchers found that SOAT1 is selectively expressed in CSC and pharmacological inhibition with STK results in robust anti-tumor effects across various preclinical mouse models, including colon, liver, lung, breast, and melanoma cancer, with low toxicity.

Is Cancer the Result of Uncontrolled Cellular Growth? a Glance into the Tumorigenic Process

April 1, 2026

[Cancer Cell International] Scientists summarize the evidence indicating that cancer originates and progresses under the action and influence of specific factors and mechanisms that regulate, in a finely way, tumor cell growth and dissemination.

Hippo Pathway at the Crossroads of Stemness and Therapeutic Resistance in Breast Cancer

April 1, 2026

[Molecular Oncology] The authors summarize the regulation of the Hippo pathway, emphasizing its significant role in coordinating stemness-related mechanisms in breast cancer.

The ITGB2-COPS3-SOX2 Axis and SOX2 Liquid-Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

March 17, 2026

[Advanced Science] High-frequency amplification of the 17p11.2 chromosomal region in osteosarcoma represents a key molecular event driving malignant progression. Investigators focused on the key gene COPS3 in this region, delving into its molecular mechanisms regulating cancer stemness.

Dual Role of LY96 in Shaping the Mesenchymal Glioblastoma Ecosystem through Stem Cell Maintenance and Macrophage MES-Like Reprogramming

March 17, 2026

[Cancer Letters] Researchers demonstrated that mesenchymal glioblastoma stem cells exhibit a preferential expression and secretion of the protein LY96.

CASC19 Stabilization by ALYREF via M5c Modification and Its Impact on SCD in Colorectal Cancer Cell Aggressiveness and Stemness

March 17, 2026

[Cell & Bioscience] Scientists elucidated the molecular mechanism by which ALYREF regulates the long non-coding RNA cancer susceptibility 19 (CASC19) through m5C modification and its impact on colorectal cancer malignancy.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.