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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Glioblastoma Stem Cells Resist Cuproptosis with Circadian Variation of Copper Levels
[Journal of Clinical Investigation] Investigators found that glioblastoma stem cells displayed relative resistance to cuproptosis with circadian variation of intracellular copper levels.
Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1
[Cancer Research] Treatment of pancreatic tumor organoids with recombinant netrin-1 enhanced cell growth, epithelial-mesenchymal transition, and cancer stemness with the upregulation of ZEB1 and SOX9 through NEO1-mediated activation of focal adhesion kinase.
The BRAF V600E/MEK/ERK/METTL3 Positive Feedback Loop Regulates Autophagy and Promotes Stemness and Invasiveness in Glioblastoma via M6a Modification
[Journal of Experimental & Clinical Cancer Research] Functional assays were performed to evaluate the impact of BRAF V600E on stemness phenotypes of glioma stem-like cells and invasive phenotypes of glioblastoma cells in vitro and in vivo.
LINC01137 Facilitates Pancreatic Cancer Stemness, Chemoresistance, and Proliferation via the Mir-7155-5p/KLF12/PI3K-Akt Axis
[International Journal of Biological Macromolecules] Scientists identified LINC01137 as a pancreatic CSC-associated lncRNA that is upregulated in pancreatic cancer tissues and cell lines.
Targeting BUB1B-Driven Cancer Stemness in Lung Adenocarcinoma: A Novel Therapeutic Strategy via PI3K/AKT Pathway Modulation
[Expert Opinion on Therapeutic Targets] Researchers explored the tumor stemness index and its role in lung adenocarcinoma to identify potential therapeutic targets.
Harnessing m6a-Regulated Cholesterol Biosynthesis Helps Impede Tumor Burden and Stemness in High-Garde Serous Ovarian Carcinoma Mesenchymal Phenotype
[Molecular Medicine] Differential proteomics revealed enrichment of core components of the m6A machinery, viz. WTAP and IGF2BP3 in stem-like cells of the mesenchymal subtype of High-Grade Serous Ovarian Carcinoma.
MiR-142-3p Targets the CXCL12/WNT/β-catenin Pathway to Regulate the Stemness of Breast Cancer Cells
[Scientific Reports] Silencing CXCL12 (using CXCL12 siRNA) suppressed the migration, EMT, and stemness of MCF 7 cells, and these effects were reversed by inhibition of miR-142-3p.
Interleukin-17 Receptor a Drives Cancer Stem-Like Properties in Colorectal Cancer through STAT3 Activation
[Journal of Cancer] Scientists investigated the role of IL-17RA in promoting cancer stem-like properties and its impact on colorectal cancer prognosis and chemoresistance.
Crosstalk between TGF-β and Wnt/β-catenin Signaling Drives Fibrogenic and Stem-Like Phenotypes in Senescent MDA-MB-231 Breast Cancer Cells
[NPJ Aging ] Chemotherapy-induced senescence was triggered by etoposide in MDA-MB-231 breast cancer cells, and their fibrogenic potential, epithelial-to-mesenchymal transition (EMT), and stemness features were examined.
Breast Cancer Stem Cells and Circulating Tumor Cells: Dual Drivers of Progression and Relapse
[World Journal of Stem Cells] This review synthesizes current knowledge on breast cancer CSC molecular programs, key signaling pathways, and microenvironmental interactions that sustain stemness.
ZIIHERA Plus TEVIMBRA and Chemotherapy: A Potential New Standard for First-Line HER2+ Advanced GEA
[BeOne Medicines, Ltd.] BeOne Medicines, Ltd. announced full results from the Phase III HERIZON-GEA-01 trial evaluating ZIIHERA®, a HER2-targeted bispecific antibody, in combination with chemotherapy, with and without PD-1 inhibitor TEVIMBRA®, as a first-line treatment for HER2+ locally advanced or metastatic gastroesophageal adenocarcinoma (GEA).
YTHDF1 Targets the Chemotherapy Response by Suppressing NOTCH1-Induced Stemness in Colorectal Cancer
[Signal Transduction and Targeted Therapy] Investigators found that the N6-methyladenosine reader YT521-B homologous domain family, member 1 (YTHDF1), promotes colorectal cancer stemness, tumorigenesis, and chemotherapy resistance.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
