Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Gene Regulatory Network Topology Governs Resistance and Treatment Escape in Glioma Stem-Like Cells

[Science Advances] Through inference of transcriptional regulatory networks of patient-derived glioma stem cells (PD-GSCs) at single-cell resolution, researchers demonstrated how the topology of transcription factor interaction networks drove distinct trajectories of cell-state transitions in PD-GSCs resistant or susceptible to cytotoxic drug treatment.

Strategies for the Isolation and Identification of Gastric Cancer Stem Cells

[Stem Cells International] Investigators discuss the surface biomarkers, isolation techniques, and identification methods of gastric cancer stem cells, as well as their role in the treatment of gastric cancer.

C-terminally Phosphorylated p27 Activates Self-Renewal Driver Genes to Program Cancer Stem Cell Expansion, Mammary Hyperplasia and Cancer

[Nature Communications] Investigators reported that CSCN abundance is transcriptionally regulated by C-terminally phosphorylated p27. Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to gene regulators of CSC self-renewal including MYC, the Notch ligand JAG1, and ANGPTL4.

Golgi Dispersal in Cancer Stem Cells Promotes Chemoresistance of Colorectal Cancer via the Golgi Stress Response

[Cell Death & Disease] Scientists demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer, and CSCs possessed a greater degree of Golgi dispersal compared with differentiated cancer cells.

NIH Awards Younghye Song $2.5 Million to Study Metabolic Rewiring in Breast Tumor Innervation

[University of Arkansas] Younghye Song, assistant professor of biomedical engineering in the U of Arkansas's College of Engineering, has recently been awarded a $2.5 million National Institutes of Health R37 grant from the National Cancer Institute to investigate the role of metabolic rewiring in breast tumor innervation.

NIH Awards Younghye Song $2.5 Million to Study Metabolic Rewiring in Breast Tumor Innervation

Younghye Song, assistant professor of biomedical engineering in the U of Arkansas's College of Engineering, has recently been awarded a $2.5 million National Institutes...

GD2 and Its Biosynthetic Enzyme GD3 Synthase Promote Tumorigenesis in Prostate Cancer by Regulating Cancer Stem Cell Behavior

[Scientific Reports] Researchers showed that GD2 was expressed in a small subpopulation of prostate cancer cells in a subset of patients and a higher proportion of metastatic tumors.

Cancer Research Transformed by Landmark Gift to Queen’s University

[Queen's University] A transformational gift is set to significantly advance cancer research at Queen’s University. With support from Murray and Cara Sinclair, the university will build research capacity in an area of existing strength, establish advanced facilities, create training opportunities, and work to improve cancer care and treatments locally, nationally, and around the world.

NIH Wanted to Make Cancer Research More Diverse. The Effort Turned Out to Be a Costly Failure

[STAT News] The NCI’s Center for Cancer Research piloted a program of paying the travel costs for screening prospective research volunteers and, when needed, their caregivers, according to an internal NCI email obtained by STAT. NCI discontinued the pilot after one year, according to an NCI spokesperson.

A Developmental Constraint Model of Cancer Cell States and Tumor Heterogeneity

[Cell] Researchers posited a model by which cancer cell states are directly constrained by the organism's “developmental map.” According to this model, a population of cancer cells traverses the developmental map, thereby generating a heterogeneous set of states whose interactions underpin emergent tumor behavior.

The HHEX-ABI2/SLC17A9 Axis Induces Cancer Stem Cell-Like Properties and Tumorigenesis in HCC

[Journal of Translational Medicine] Investigators reported that HHEX was a novel CSCs target for hepatocellular carcinoma (HCC). They found that HHEX was overexpressed in HCC tissues and high expression of HHEX was associated with poor survival.

UCHL3 Induces Radiation Resistance and Acquisition of Mesenchymal Phenotypes by Deubiquitinating POLD4 in Glioma Stem Cells

[Cellular and Molecular Life Sciences] Expression and prognosis of the POLD family were analyzed in TCGA, the Chinese Glioma Genome Atlas and GEO datasets. Tumorsphere formation and in vitro limiting dilution assay were performed to investigate the effect of UCHL3-POLD4 on glioma stem cells self-renewal.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.