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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
[Cancer Discovery] Using a novel circulating tumor cell (CTC) isolation approach, researchers collected 273 CTC samples from 117 patients with metastatic prostate cancer for RNA sequencing.
In Silico Analysis Unveiling the Role of Cancer Stem Cells in Immunotherapy Resistance of Immune Checkpoint-High Pancreatic Adenocarcinoma
[Scientific Reports] By mining cancer datasets using R2, available clinical trial data, and Kaplan–Meier analysis from GEPIA depicted that unlike low-responder cancers, high-responder cancers furnish higher immune checkpoint expression, that upon lowering may provide better prognosis.
Combined Targeting of Glioblastoma Stem Cells of Different Cellular States Disrupts Malignant Progression
[Nature Communications] Researchers found that classical (CL) and mesenchymal (MES) glioblastoma (GBM) stem cells were enriched in reactive immune region and high CL-MES signature informed poor prognosis in GBM.
The FOXP1-ABCG2 Axis Promotes the Proliferation of Cancer Stem Cells and Induces Chemoresistance in Pancreatic Cancer
[Cancer Gene Therapy] Investigators found that the expression of the transcription factor Forkhead Box P1 (FOXP1) was elevated in chemoresistant pancreatic cancer and crucial for establishing CSC characteristics.
Gastroesophageal Circulating Tumor Cell Crosstalk with Peripheral Immune System Guides CTC Survival and Proliferation
[Cell Death & Disease] Scientists established an in-vitro co-culture system consisting of immune cells and circulating tumor cells (CTCs) from the same patient, which increased the success rate in the establishment of CTC-derived long-term cell cultures.
DMC-BH Derivative DMC-GF Inhibits the Growth of Glioma Stem Cells by Targeting the TRIM33/SLC25A1/Mitochondrial Oxidative Phosphorylation Pathway
[Journal of Translational Medicine] Investigators developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and metabolic stability compared to its predecessor DMC-BH.
Clusterin-Mediated Polarization of M2 Macrophages: A Mechanism of Temozolomide Resistance in Glioblastoma Stem Cells
[Stem Cell Research & Therapy] Scientists investigated a novel resistance mechanism involving glioblastoma stem cells and the polarization of M2-type macrophages, mediated by the extracellular vesicle-based transfer of Clusterin.
Targeting the AKT/mTOR Pathway Attenuates the Metastatic Potential of Colorectal Carcinoma Circulating Tumor Cells in a Murine Xenotransplantation Model
[Molecular Oncology] The susceptibility of the colon cancer circulating tumor cell (CTC)-derived cell line CTC-MCC-41 to AKT and mammalian target of rapamycin (mTOR) inhibitors was evaluated.
Multi-Omic Analyses Reveal Aberrant DNA Methylation Patterns and the Associated Biomarkers of Nasopharyngeal Carcinoma and Its Cancer Stem Cells
[Scientific Reports] The authors integratively performed DNA methylome and transcriptome combined with single-nucleus RNA sequencing to investigate DNA methylation and gene expression patterns of nasopharyngeal carcinoma and CSCs.
Role of Octamer Transcription Factor 4 in Proliferation, Migration, Drug Sensitivity, and Stemness Maintenance of Pancreatic Cancer Cells
[World Journal of Clinical Oncology] Scientists investigated the role of Octamer transcription factor 4 in pancreatic CSCs and its effect on pancreatic cancer cell proliferation, migration, drug sensitivity, and stemness maintenance.
Role of Noncoding RNA As a Pacemaker in Cancer Stem Cell Regulation: A Review Article
[Journal of the Egyptian National Cancer Institute] The authors provide insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.
Windsor Hospital’S New Linear Accelerator Will Expand Cancer Treatment Capacity
[CBC News] A new machine at Windsor Regional Hospital could help deliver 26,000 more cancer treatments a year. The hospital's new linear accelerator is a new, state-of-the-art machine that delivers targeted radiation treatments to people with cancer.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
