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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
The Evolutionary Theory of Cancer: Challenges and Potential Solutions
[Nature Reviews Cancer] The authors identify limits in the theoretical performance of the clonal evolution model and provide solutions to overcome those limits.
Autofluorescent Cancer Stem Cells: Potential Biomarker to Predict Recurrence in Resected Colorectal Tumor
[Cancer Research Communications] 75 freshly-resected tumors were analyzed, by flow cytometry. Autofluorescence (AF) was categorized as high or low and results were correlated with histological features and clinical variables.
Epigenetic Control of Immunoevasion in Cancer Stem Cells
[Trends In Cancer] Investigators summarize epigenetic modifications of DNA and histones through which CSCs evade immune recognition or elimination, and propose that such alterations constitute promising therapeutic targets to increase the sensitivity of some malignancies to immunotherapy.
Development of a Prognostic Model for NSCLC Based on Differential Genes in Tumour Stem Cells
[Scientific Reports] Investigators performed univariate regression analyses on the DEGs to identify potential prognostic genes. They created a machine learning framework based on potential prognostic genes, which combines 10 machine learning methods and their 101 combinations to get the optimal prognostic risk model.
ALDH1A3 Is the Switch That Determines the Balance of ALDH+ and CD24−CD44+ Cancer Stem Cells, EMT-MET, and Glucose Metabolism in Breast Cancer
[Oncogene] The authors found that aldehyde dehydrogenase 1A3 (ALDH1A3) regulates these cancer-promoting processes and the abundance of the two distinct breast CSC populations defined by high ALDH activity and CD24−CD44+ cell surface expression.
Circulating Tumor DNA-Based Stratification Strategy for Chemotherapy Plus PD-1 Inhibitor in Advanced Non-Small-Cell Lung Cancer
[Cancer Cell] Investigators performed high-throughput panel-based deep next-generation sequencing and low-pass whole genome sequencing on prospectively collected circulating tumor DNA specimens from 460 patients in the phase 3 CHOICE-01 study at different time points.
Colorado Blood Cancer Institute Using Patients’ Stem Cells to Treat Their Autoimmune Diseases
[Denver7] The Colorado Blood Cancer Institute at Presbyterian/St. Luke’s is leading the way in a type of stem cell therapy to treat autoimmune diseases, including multiple sclerosis.
Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity
[Advanced Science] Two new potent small-molecule inhibitors of Arf1, identified as DU101 and DU102, for cancer therapy are introduced. Preclinical tumor models demonstrated that these inhibitors triggered a cascade of aging in CSCs and enhanced anti-tumor immunity in mouse cancer and PDX models.
The Dual Role of POSTN in Maintaining Glioblastoma Stem Cells and the Immunosuppressive Phenotype of Microglia in Glioblastoma
[Journal of Experimental & Clinical Cancer Research] Scientists investigated the role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia.
Acid-Sensing Ion Channel 3 Is a New Potential Therapeutic Target for the Control of Glioblastoma Cancer Stem Cells Growth
[Scientific Reports] Researchers reported that the acid-sensing ion channel 3 isoform, usually absent in the central nervous system and present in the peripheral nervous system, was enriched in human glioblastoma cancer stem cells while poorly expressed in the healthy human brain.
Genetically Engineered CD276-Anchoring Biomimetic Nanovesicles Target Senescent Escaped Tumor Cells to Overcome Chemoresistant and Immunosuppressive Breast Cancer
[Biomaterials] Investigators developed new approaches for selectively killing senescent-escape CSCs. High CD276 expression in multidrug-resistant breast cancer cells, facilitated immune evasion by low-immunogenic senescent escape CSCs.
Epigenetic Therapy Potentiates Transposable Element Transcription to Create Tumor-Enriched Antigens in Glioblastoma Cells
[Nature Genetics] Researchers treated patient-derived primary glioblastoma stem cell lines, an astrocyte cell line, and primary fibroblast cell lines with epigenetic drugs, and identified treatment-induced, transposable element-derived transcripts preferentially expressed in cancer cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
