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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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YTHDF1 Targets the Chemotherapy Response by Suppressing NOTCH1-Induced Stemness in Colorectal Cancer
[Signal Transduction and Targeted Therapy] Investigators found that the N6-methyladenosine reader YT521-B homologous domain family, member 1 (YTHDF1), promotes colorectal cancer stemness, tumorigenesis, and chemotherapy resistance.
Nucleophosmin Supports WNT-Driven Hyperproliferation and Tumor Initiation
[Nature Genetics] The authors demonstrated that ucleophosmin (Npm1) is upregulated after APC loss in WNT-responsive tissues and supports WNT-driven intestinal and liver tumorigenesis.
AQP5: A Functional Gastric Cancer Stem Cell Marker in Mouse and Human Tumors
[Science] Scientists reported that the surface marker AQP5 enriches for gastric CSCs in mouse and human tumors arising from the distal pyloric stomach.
Targeting IL-1/IRAK1/4 Signaling in Acute Myeloid Leukemia Stem Cells following Treatment and Relapse
[Leukemia] The authors presented transcriptome analyses of functionally defined leukemia stem cell populations at diagnosis and relapse, revealing significant alterations in IL-1 signaling.
Targeting Kinesin Family Member 20A Sensitizes Stem-Like Triple-Negative Breast Cancer Cells to Standard Chemotherapy
[Journal of Clinical Investigation] Investigators dissected the transcriptome of breast CSCs (BCSCs) and identified kinesin family member 20A as a key regulator of BCSC survival and triple negative breast cancer tumorigenesis.
Targeting of the m6a Eraser ALKBH5 Suppresses Stemness and Chemoresistance of Colorectal Cancer
[Nature Communications] Researchers found that AlkB homolog 5 (ALKBH5) expression positively correlates with CSC markers in colorectal cancer patients. ALKBH5 induces self-renewal and stemness markers in colorectal CSCs and patient-derived organoids.
Targeting Chaperone-Mediated Autophagy Inhibits Properties of Glioblastoma Stem Cells and Restores Anti-Tumor Immunity
[Nature Communications] Investigators showed that chaperone-mediated autophagy (CMA) is upregulated in patient-derived glioblastoma stem cells, indicated by a significant increase in the lysosomal abundance of the CMA receptor, lysosome-associated membrane protein 2 A.
HIF-1-Mediated ISG20 Expression Promotes Breast Cancer Stemness and Immune Evasion
[Journal of Experimental Medicine] The authors demonstrated that transcription of the ISG20 gene, which encodes an RNA exonuclease, is activated by HIF-1 in triple negative breast cancer cells.
Matrix Stiffness Maintains Bladder Cancer Stemness via Integrin-Nuclear Skeleton Axis
[Cell Death & Disease] Scientists showed that as bladder cancer progresses, matrix stiffness increases, and tumor stemness increases.
Tumor-Educated-Platelets Interact with Breast Cancer-Stem-Cells via P-Selectin-PSGL1 and Ensure Stemness and Metastasis through WNT-β-Catenin-VEGF-VEGFR2 Intra-Cellular Signaling: Therapeutic Modulation by Aspirin
[Breast Cancer Research] Impact of tumor educated platelets on breast CSCs was evaluated from primary breast tumor and blood samples of luminal A/triple negative breast cancer patients along with EC/4T1 murine breast tumor models and MCF-7/MDA-MB-231 cell lines.
NRAV Promotes HCC Stemness via the m6a-Regulated Let-7c-5p/LIN28B Axis
[Cancer Gene Therapy] Investigators identified negative regulator of antiviral response (NRAV) as an m6A-modified lncRNA that promotes HCC stemness through a defined molecular axis.
Inhibition of the Mevalonate Pathway Targets Neuroblastoma Stem Cells
[Pharmacology] Researchers observed the use of mevalonate pathway inhibitors against the CSC population of high-risk neuroblastoma cell lines SH-SY5Y, SK-N-AS, and SK-N-BE(2)-C using spheroid-based assays.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
