Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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Cancer Stem Cell Plasticity: Mechanisms, Immune Microenvironment Crosstalk, and Therapeutic Implications

July 22, 2026

[Journal of Hematology & Oncology] The authors summarize recent advances in our understanding of CSC plasticity, with a particular focus on the bidirectional interplay between CSCs and the tumor immune microenvironment.

LEF1 and Niche Factors Determine T Cell Stemness across Chronic Diseases

July 22, 2026

[Cell] Using preclinical models of autoimmune type 1 diabetes and chronic infection, researchers discovered that a small subset of TCF1hi T cells express the transcription factor LEF1. LEF1+ TCF1hi T cells define a true self-renewing T cell pool.

Progressive Intestinal Tumor Cell Plasticity, Myc Activation, and Loss of Lgr5 Tumor Stem Cell Lineage Commitment Upon Wnt Depletion

July 22, 2026

[Science Advances] Scientists demonstrated that a plastic cell state (PSC) is present already in polyps from patients with familial adenomatous polyposis and in mouse intestinal adenomas, in which PCS is associated with PROX1+ tumor stem cells.

ENO2 Sustains Cancer Stemness and Metastatic Competence through a Phosphoenolpyruvate-Dependent Metabolic Axis in Triple-Negative Breast Cancer

July 22, 2026

[Cell Death & Disease] Investigators demonstrated that Enolase 2 (ENO2) sustains CSC properties and metastatic competence through a phosphoenolpyruvate-dependent metabolic axis.

$2.5 Million Department of Defense Grant Funds Development of Targeted Therapy for Triple-Negative Breast Cancer

July 22, 2026

[Weill Cornell Medicine] Weill Cornell Medicine has received a $2.5 million, three-year grant from the Department of Defense to develop therapies with fewer side effects for triple-negative breast cancer.

Targeting Mitotic Kinesin KIF20A: A Differentiation-Based Therapeutic Strategy for Glioblastoma Stem/Progenitor Cells

July 22, 2026

[Stem Cell Reports] Researchers investigated the therapeutic potential of targeting mitotic kinesin KIF20A in glioblastom stem/progenitor cells. KIF20A is a crucial component of cytokinetic machinery and cooperates with a network of cell fate regulators to balance proliferative and differentiative divisions in neural stem/progenitor cells.

Rbm5 Sustains Leukemia Stem Cells through a Myc-Driven Transcriptional Circuitry

July 22, 2026

[Leukemia] Investigators showed that Rbm5 selectively promotes murine leukemogenesis, and maintains leukemia stem cell (LSC) self-renewal in vivo. Rbm5 is highly expressed in LSCs, and its deficiency results in specifically defective LSC function, along with inhibition of self-renewal gene expression and induction of myeloid differentiation.

PAPOLA-Mediated Hyperactive Polyadenylation Promotes Leukemogenesis and Leukemia Stem Cell Self-Renewal through Metabolic Reprogramming

July 22, 2026

[Nature Cancer] Using primary acute myeloid leukemia samples, leukemia cell lines and multiple mouse models, scientists demonstrated that PAPOLA-driven hyperactive polyadenylation promotes leukemogenesis and sustains leukemia stem cell maintenance.

Stem-Like Precursors of Exhausted Th Cells Upheld by a Tox-Myb-Eomes Transcriptional Hierarchy Propagate Th Cell Responses in Chronic Infection

July 22, 2026

[Immunity] The authors identified a population of CD4+ T cells that expressed CD62L and the inhibitory receptor PD-1 and exhibited both features of exhaustion and stemness. These cells acted as precursors of T helper cells and sustained Th cell immunity during chronic lymphocytic choriomeningitis virus infection.

LEF1 and Niche Factors Determine T Cell Stemness across Chronic Diseases

July 8, 2026

[Cell] Using preclinical models of autoimmune type 1 diabetes and chronic infection, scientists discovered that a small subset of TCF1hi T cells express the transcription factor LEF1. LEF1+ TCF1hi T cells define a true self-renewing stem T cell pool.

circPARPBP Promotes Cancer Stemness and Chemoresistance in Triple-Negative Breast Cancer through Recruiting SRCAP Complex to Activate CCL20 Transcription

July 8, 2026

[Oncogene] Researchers reported three key innovations: the discovery of a novel oncogenic circRNA, circPARPBP, as a driver of chemoresistance; the elucidation of its mechanism through the recruitment of the SRCAP complex to activate CCL20 transcription and cancer stemness; and the demonstration that the natural compound isoliquiritigenin suppresses this axis to overcome chemoresistance.

Aptamer-Based Inhibition of MNK1 Reduces Pancreatic Ductal Adenocarcinoma Growth by Targeting Cancer Stem Cells

July 8, 2026

[Journal of Biomedical Science] Scientists showed the potential of apMNKQ2, a DNA aptamer targeting MNK1, to therapeutically target CSCs and reduce pancreatic ductal adenocarcinoma tumor burden in patient-derived xenografts.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.