Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Cancer-Associated Fibroblast-Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance

[Cancer Research] To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, scientists focused on the role of cancer-associated fibroblasts.

IGFBP5 Is an ROR1 Ligand Promoting Glioblastoma Invasion via ROR1/HER2-CREB Signaling Axis

[Nature Communications] Researchers reported Insulin-like Growth Factor-Binding Protein 5 (IGFBP5), a ligand for Receptor tyrosine kinase like Orphan Receptor 1 (ROR1), as a promising target for glioblastoma stem-like cell invasion.

The Roles and Molecular Mechanisms of Long Non-Coding RNA WT1-AS in the Maintenance and Development of Gastric Cancer Stem Cells

[Heliyon] The authors showed that long non-coding RNA WT1 antisense RNA (WT1-AS) negatively regulated Wilms’ tumor 1 (WT1) expression in gastric CSCs.

RHAMM Marks Proliferative Subpopulation of Human Colorectal Cancer Stem Cells

[Cancer Science] Scientists investigated organoids, miniature forms of tumor tissues with reconstructing cellular diversity, to identify specific marker to characterize CSCs in heterogeneous tumors.

Silicon Nanowire Array Overcomes Chemotherapeutic Resistance by Inducing the Differentiation of Breast Cancer Stem Cells

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] Investigators reported the silicon nanowire array differentiated MCF-7-derived breast CSCs into non-CSCs by modulating the morphology of cells.

Adipocytes Reprogram Prostate Cancer Stem Cell Machinery

[Journal of Cell Communication and Signaling] Researchers demonstrated that 3T3-L1 adipocyte conditioned media could endow PC3 and DU145 prostate cancer cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression.

SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake

[Neuro-Oncology] In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastomas cholesterol biosynthesis, proliferation, and self-renewal.

Deciphering the Molecular Mechanism of the THBS1 Gene in the TNF Signaling Axis in Glioma Stem Cells

[Cellular Signalling] To investigate the relevant molecular mechanism and signal pathway of glioma stem cell behavior mediated by thrombospondin 1 (THBS1), U251 astroglioma cells and glioma stem cells were taken as model cells for in vitro experiments.

Eliciting Effective Tumor Immunity against Ovarian Cancer by Cancer Stem Cell Vaccination

[Biomedicine & Pharmacotherapy] Scientists evaluated the immune effects of CSCs vaccines on ovarian cancer (OC). The CD44+CD117+CSCs were isolated from human OC HO8910 and SKOV3 cells using the magnetic cell sorting system.

Depleting DDX1 Sensitizes Non-Small Cell Lung Cancer Cells to Chemotherapy by Attenuating Cancer Stem Cell Traits

[Life Sciences] The authors found that depleting DEAD-box helicase 1 (DDX1) increased the sensitivity of non-small cell lung cancer cells to the chemotherapy drug cisplatin, increased cell apoptosis, and inhibited cell migration and invasion.

Circulating Tumor Cells in Gastrointestinal Cancers: Food for Thought?

[3 Biotech] Scientists outline a selection of the literature describing biological features of circulating tumor cells with an impact on their metastasis forming ability in different gastrointestinal cancers.

PVT1 Inhibition Stimulates Anti-tumor Immunity, Prevents Metastasis, and Depletes Cancer Stem Cells in Squamous Cell Carcinoma

[Cell Death & Disease] Scientists identified a long noncoding RNA, termed PVT1, which was highly expressed in CSCs and correlated closely with lymph node metastasis of head and neck squamous cell carcinoma.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.