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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Unleashing T Cell Surveillance for the Eradication of Quiescent Persister Tumor Cells Resistant to Neoadjuvant Chemotherapy
[Developmental Cell] Researchers identified quiescent persister tumor cells (PTCs) as a critical determinant of therapeutic failure. Elevated PTC abundance correlates with poor long-term prognosis, even in patients exhibiting an initial response to treatment.
High Mannose Content of Mesenchymal Glioblastoma Correlates with Hydroxyl Proton Transfer-Weighted (HPTw) MRI As Noninvasive Biomarker of Tumor Aggressiveness
[Science Advances] Researchers indicated that Hydroxyl proton transfer–weighted magnetic resonance imaging correlates with high mannose and possibly other saccharide levels in mesenchymal glioblastoma cells, serving as a surrogate imaging biomarker for predicting tumor aggressiveness and recurrence.
UMass Chan Scientist Marcus Ruscetti Receives 2026 Pershing Square Sohn Cancer Prize
[UMass Chan Medical School] Dr. Marcus Ruscetti, is one of 13 investigators to receive the prestigious 2026 Pershing Square Sohn Cancer Prize from the Pershing Square Sohn Cancer Research Alliance. Dr. Ruscetti will study how cells in the liver experiencing senescence create an immune-suppressive environment that enables pancreatic cancer metastasis.
OICR Supports Four New Studies Seeking Cancer Insights from Existing Patient Samples and Data
[OICR] Four new research studies funded by the Ontario Institute for Cancer Research (OICR) will deliver innovations by maximizing the impact of existing research and making the most out of patient contributions. OICR is supporting the studies through CATALYST, a new funding stream for research that leverages available patient data and donated samples to advance new insights about detecting, diagnosing and treating cancer.
GDF15 Promotes 5-Fluorouracil and Oxaliplatin Resistance by Promoting Stem Cell-Like Phenotype in Colorectal Cancer
[British Journal of Cancer] Scientists conducted an integrated analysis of RNA sequencing data using established chemoresistant colorectal cancer (CRC) cell lines and publicly available single-cell transcriptomic datasets of clinical CRC samples to clarify the underlying mechanisms associated with acquired chemoresistance.
High-Throughput Generation of Patient-Derived Cancer Stem Cells for Precision Medicine Using a Microwell-Chip Platform
[Nature Cell Biology] Investigators showed a microwell cell-chip culture platform that enabled rapid, high-throughput generation of uniform micro-tumourspheres from limited breast cancer specimens, such as puncture biopsies, facilitating functional CSC enrichment and personalized drug testing within eight days.
Mechanisms of Chemoresistance in Gastric Cancer: Interplay between microRNAs and the Tumor Microenvironment
[Clinical and Translational Oncology] The authors summarize the principal mechanisms of chemoresistance in gastric cancer and synthesize evidence on how microRNAs—derived from tumor cells and the tumor microenvironment—promote or reverse resistance to commonly used chemotherapeutic agents and targeted therapy/immunotherapies.
Circ-ABCA1 Promotes Breast Cancer Stem Cell-Mediated Malignant Progression by Modulating Mir-33a-5p/EIF4A3 Axis
[Clinical and Experimental Medicine] Researchers demonstrated that circ-ABCA1 promotes breast cancer stem cell-mediated malignant progression by modulating miR-33a-5p/EIF4A3 axis.
PIEZO1 Is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A-SLC7A11 Axis-Mediated Ferroptosis Defense
[Advanced Science] Researchers uncovered the mechanosensor PIEZO1 as a key factor in promoting AML progression and maintaining LSC stemness by HIF1A-SLC7A11 axis-mediated ferroptosis defense.
A Ketogenesis-Ferroptosis Axis Maintains Leukemic Stem Cell Survival and Leukemia Progression
[Cell Stem Cell] Investigators showed that leukemic stem cells in acute myeloid leukemia exhibit elevated ketogenesis, driven by fatty acid oxidation, to produce β-hydroxybutyrate.
Leukemic Stem Cell Subtypes Determine Venetoclax Resistance and Therapeutic Vulnerabilities in AML
[Cell Stem Cell] By molecular and functional profiling of leukemic stem cells (LSC) from >150 patients, researchers identified four LSC subtypes. These mirror distinct hematopoietic lineage stages, which determine the expression ratio between the venetoclax target BCL-2 and resistance-inducing proteins MCL-1 and BCL-xL.
Cancer Stem Cells Orchestrate Immune Evasion through Extracellular Vesicle-Mediated Non-Canonical Signaling Pathways
[Cancer Cell] Using multiplexed single-cell proteomics to analyze 50 tumor microenvironment-associated proteins across treatment-naive triple-negative breast cancer (TNBC) specimens, scientists discovered that CSCs drive differentiation and expansion of regulatory T cells via extracellular vesicle-mediated paracrine signaling.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
