Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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Reactive Oligodendrocytes Promote Glioblastoma Progression through CCL5/CCR5-Mediated Glioma Stem Cell Maintenance

January 21, 2026

[Neuron] Researchers utilized single-cell and spatial transcriptomics from primary and recurrent glioblastoma (GBM) tumors, immunohistochemistry, cytokine profiling, and migration assays to show that GBM cells recruit oligodendrocytes to the tumor border via fractalkine signaling.

SNORA49 Negatively Regulates Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis via Suppressing SOX9 Transcription

January 21, 2026

[Nature Communications] The authors identified a conserved small nucleolar RNA, SNORA49, which is lowly expressed in liver CSCs, as a negative regulator of CSC self-renewal.

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance

January 21, 2026

[Advanced Science] Using integrative single-cell RNA sequencing, researchers identified that the upregulation of mitochondrial calcium uniporter may contribute to chemoresistance and stemness maintenance in pancreatic ductal adenocarcinoma.

AQP7 Suppresses Cell Stemness and Metastasis by Targeting Wnt Signaling in Basal-Like Breast Cancer

January 21, 2026

[Expert Opinion on Therapeutic Targets] Investigators performed functional assays in vitro and in vivo using basal-like human breast cancer cells with or without expression of AQP7, including cancer cell stemness, cell migration and invasion, and tumorigenesis in mice.

Cytoskeleton Reorganization Induced by a Novel K6-K14 Keratin Fusion Promotes Cancer Stemness and Cellular Plasticity via cGAS-STING Selection

January 21, 2026

[Oncogenesis] Upregulation of the partial epithelial-mesenchymal transition program by cytoskeleton reorganization was defined as a key step for dormant cancer cells to reactivate and regain their mechanical properties.

Bulk Sequencing Combined with Single-Cell Sequencing Identifies High Expression of VCAN in Fibroblasts Promoting the Progression of High-Stemness Gastric Adenocarcinoma Cells

January 21, 2026

[FASEB Journal] Comprehensive analysis of multiple databases revealed significantly higher versican expression in stomach adenocarcinoma tissues compared to normal tissues, correlating with poor patient prognosis.

SPRED2 Suppresses the Stemness of Hepatocellular Carcinoma through the p53/miR-506-3p/KLF4 Pathway

January 21, 2026

[Cancer Biology & Medicine] Three human hepatocellular carcinoma cell lines were used. Cells were transfected to downregulate or overexpress proteins. Western blot and RT-qPCR were used to evaluate the level of protein and mRNA expression.

APOBEC3B Enhances the Efficacy of PARP Inhibitors in Elimination of Ovarian Cancer Stem Cell

January 21, 2026

[Scientific Reports] The authors reported that CSC-like tumorspheres exhibit reduced A3B expression compared to non-CSC adherent counterparts.

The Pseudouridine Synthase PUS7 Is Associated with Stemness and Represents a Potential Therapeutic Target in Triple-Negative Breast Cancer Cells

January 21, 2026

[Scientific Reports] Investigators examined the roles of pseudouridine synthases in modulating the biological properties of triple-negative breast cancer using bioinformatics and experimental investigations.

Molecular Analysis of Tumor Recurrence Using Established Cancer Stem Cell-Line and Drug Discovery

January 21, 2026

[International Journal of Clinical Oncology] Scientists developed LGR5-specific monoclonal antibodies and a high-sensitivity immunofluorescence method to visualize the stem cell marker LGR5 in clinical tumors.

Circulating Tumor Cells As a Window into Lethality in Prostate Cancer

January 21, 2026

[Nature Reviews Urology] The variable biology of prostate cancer seems to be recapitulated in the phenotypic heterogeneity of circulating tumor cells (CTCs). CTC sampling offers a liquid biopsy method to achieve minimally invasive longitudinal sampling for disease monitoring.

Brian Cunniff, Ph.D., Named Inaugural Juckett Faculty Scholar at the UVM Cancer Center

January 21, 2026

[The University of Vermont Cancer Center ] The University of Vermont (UVM) Cancer Center announced the appointment of Brian Cunniff, Ph.D., as the inaugural Juckett Faculty Scholar, a distinguished faculty honor recognizing exceptional cancer researchers whose work meaningfully advances the center’s mission.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.