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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Chromatin Looping-Based CRISPR Screen Identifies TLK2 As Chromatin Loop Formation Regulator in Cancer Stemness Plasticity
[Nature Communications] Scientists revealed that tousled-like kinase 2 (TLK2) functions as a key regulator of chromatin loop formation during the cancer stemness transition.
Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in T(8;21) Acute Myeloid Leukemia
[Cancer Research] Researchers showed that SETD8, a lysine methyltransferase that monomethylates lysine 20 of histone H4, is essential for the maintenance of stemness in t(8;21) acute myeloid leukemia leukemic stem cells.
Dual Regulation of FZD1/7 by IGF2BP3 Enhances Stem-Like Properties and Carboplatin Resistance in Triple-Negative Breast Cancer
[Cancer Letters] Investigators identified IGF2BP3 as a dominant m6A reader enriched in triple-negative breast cancer-cancer stem cells through transcriptomic analysis of the TCGA-BRCA dataset and validation by fluorescence-activated cell sorting.
The ALDH2-PKC Delta-SHMT2 Axis Regulates Cellular Metabolic Plasticity to Promote Leukemia Stem Cells Self-Renewal and Evasion of Chemotherapy in AML
[Cancer Letters] The authors investigated the role of aldehyde dehydrogenase 2 (ALDH2) in chemotherapy resistance in patients with relapsed/refractory acute myeloid leukemia (AML) and demonstrated that elevated ALDH2 expression in leukemic stem cells is closely associated with AML relapse and treatment resistance.
Spatial Self-Organization of Cancer Stem Cell Niches Revealed by Live Single-Cell Imaging
[Stem Cell Research & Therapy] Researchers disentangled how phenotypic inheritance and intercellular interactions orchestrate the spatio-temporal self-organization of cancer cell heterogeneity, maintaining a subpopulation of CSCs within niches.
Cytoplasmic P21 Promotes Stemness of Colon Cancer Cells via Activation of the NFκB Pathway
[Molecular Oncology] Since cytoplasmic p21 correlated with advanced stage and metastasis in colorectal cancer patients, scientists investigated its causal role in CSC features in vitro and in vivo.
β-Elemene Suppresses Proliferation, Migration, and Stemness in Triple-Negative Breast Cancer by Inhibiting SIX-1
[Drug Development Research] β-Elemene suppressed triple-negative breast cancer proliferation, migration, invasion, and stemness in vitro by modulating the SIX-1/β-Catenin/ID2 axis, suggesting its promise as a candidate for further therapeutic development.
A FUT2-β-Catenin Axis Mediates Chemoresistance and Cancer Stemness in Lung Adenocarcinoma
[Cellular Signalling] Bioinformatic analysis indicated a positive association between fucosyltransferase 2 (FUT2) expression and resistance to chemotherapy in lung adenocarcinoma (LUAD) patients. FUT2 knockdown suppressed cancer stemness in LUAD.
Amlodipine Synergizes with Temozolomide against Glioma Stem Cells by Modulating MGMT Expression through Downregulation of the AKT/GSK3β/β-Catenin Axis
[Cellular Signalling] Investigators revealed that amlodipine inhibited the glioma stem cells' viability and induced apoptosis, cell cycle arrest in vitro.
Targeting Ferroptosis in Cancer Stem Cells: A Novel Strategy to Improve Cancer Treatment
[Genes & Diseases] A comprehensive understanding of the interplay between ferroptosis and CSCs' biology is essential for developing innovative strategies aimed at eradicating these elusive cells, thereby improving cancer treatment outcomes and reducing recurrence rates.
Regulating Ferroptosis in Leukemic Stem Cells: From Stemness Preservation to Targeted Differentiation Strategies
[Stem Cell Reviews and Reports] The authors provide a systematic analysis of leukemic stem cell ferroptosis resistance and explore the interplay between iron metabolism, lipid peroxidation, and antioxidant defense mechanisms.
CERo Therapeutics Initiates Second Cohort of Phase 1 Clinical Trial of CER-1236 in AML with Patient Receiving Significant Increase in Dosing
[CERo Therapeutics Holdings, Inc. (Globe Newswire)] CERo Therapeutics Holdings, Inc., announced the initiation of the second cohort of its Phase I CER-1236 clinical trial focused on patients with acute myeloid leukemia
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
