Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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CircKIAA1617 Promotes Stemness via USP14/PGRMC1-Mediated Autophagy and Lipid Metabolism Reprogramming in ER-Positive Breast Cancer

February 4, 2026

[Molecular Cancer] CircKIAA1617 was identified through high-throughput RNA sequencing in ER-positive breast cancer (BC) . Gain- and loss-of-function assays were performed to evaluate the functions of circKIAA1617 in ER-positive BC cells.

HNRNPF Increases MAF and CCNB2 Levels To Promote Cancer Cell Stemness and Progression of Pancreatic Ductal Adenocarcinoma

February 4, 2026

[Stem Cell Reviews and Reports] The authors investigated the impact of heterogeneous nuclear ribonucleoprotein F (HNRNPF) on tumor stemness by regulating musculoaponeurotic fibrosarcoma (MAF) stability and cyclin B2 (CCNB2) transcription in pancreatic ductal adenocarcinoma.

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

February 4, 2026

[Cancer Science] The authors investigated how Wnt3a and/or Loxl2 knockdown affects liver CSCs and orthotopic tumor growth in mice, and explores the role of ferroptosis-related genes.

SNORA49 Negatively Regulates Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis via Suppressing SOX9 Transcription

February 4, 2026

[Nature Communications] Scientists identified a conserved small nucleolar RNA, SNORA49, which is lowly expressed in liver CSCs, as a negative regulator of CSC self-renewal.

Notch1 O-GlcNAcylation Drives Tumor Stemness and Mechanoadaptation to a Stiff Microenvironment and Promotes Chordoma Recurrence

February 4, 2026

[Journal of Clinical Investigation] Researchers identified cytoskeleton rearrangement, stress fiber reorganization, enhanced stemness, and Notch signaling activation in recurrent chordoma tissues or cell lines surviving stiff substrates.

TENT5A Maintains MYC mRNA Stability to Enhance Osteosarcoma Stemness

February 4, 2026

[Cancer Research] Investigators showed that cytoplasmic mRNA (poly(A)) sustains MYC activation in osteosarcoma. Multi-omics profiling and single-cell transcriptomics identified TENT5A as selectively upregulated in MYC-activated tumors and enriched in proliferative, stem-like populations.

Cancer Stem Cell-Driven Drug Resistance in Colorectal Carcinoma: Molecular Aspects and Therapeutic Potentials

February 4, 2026

[Molecular Cancer] Investigators describe the molecular mechanisms of CSCs-driven drug resistance in colorectal cancer, highlighting the current and emerging therapeutic strategies to guide the development of more effective, personalized interventions.

PreciseOnco Research Consortium Awarded EUR 14.9 Million IHI Grant to Drive Breakthroughs in Precision Cancer Treatment

February 4, 2026

[Royal Philips] Royal Philips has been awarded funding from the EU’s Innovative Health Initiative (IHI) to advance precision cancer treatment through the integration of advanced medical imaging, robotic assistance, and minimally invasive therapies.

Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

February 3, 2026

[Blood Cancer Discovery] By reconstructing epigenetic ontogeny in juvenile myelomonocytic leukemia (JMML), investigators identified a postnatal maturation state of JMML stem cells with high transcriptional plasticity indicative of oncofetal reprogramming in high-risk disease.

DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML but Is Associated with Increased Leukemia Stem Cell Frequency

February 3, 2026

[Cancer Discovery] The authors developed CRISPR-based methods to directly correct DNMT3A^R882 mutations in leukemic cells obtained from patients.

Reactive Oligodendrocytes Promote Glioblastoma Progression through CCL5/CCR5-Mediated Glioma Stem Cell Maintenance

January 21, 2026

[Neuron] Researchers utilized single-cell and spatial transcriptomics from primary and recurrent glioblastoma (GBM) tumors, immunohistochemistry, cytokine profiling, and migration assays to show that GBM cells recruit oligodendrocytes to the tumor border via fractalkine signaling.

SNORA49 Negatively Regulates Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis via Suppressing SOX9 Transcription

January 21, 2026

[Nature Communications] The authors identified a conserved small nucleolar RNA, SNORA49, which is lowly expressed in liver CSCs, as a negative regulator of CSC self-renewal.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.