Researchers demonstrated that a key GAS6/AXL axis was highly activated in acute myeloid leukemia patient cells, particularly in stem/progenitor cells.
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Niu, X., Rothe, K., Chen, M., Grasedieck, S., Li, R., Nam, S.-E., Zhang, X., Novakovskiy, G., Ahn, Y.-H., Maksakova, I. A., Lai, S., Zhang, H., Yan, J., Liu, H., Zhao, Y., Wu, D., Ge, Y., Wasserman, W., Rouhi, A., … Jiang, X. (2021). Targeting AXL Kinase Sensitizes Leukemic Stem and Progenitor Cells to Venetoclax Treatment in Acute Myeloid Leukemia. Blood, blood.2020007651. https://doi.org/10.1182/blood.2020007651 Cite
Pancreatic ductal adenocarcinoma patients who underwent surgical resection between 01/2012–06/2014 were identified. CD44 and epithelial-specific antigen expression was assessed by immunohistochemistry.
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Askan, G., Sahin, I. Halil., Chou, J. F., Yavas, A., Capanu, M., Iacobuzio-Donahue, C. A., Basturk, O., & O’Reilly, E. M. (2021). Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma. BMC Cancer, 21(1), 385. https://doi.org/10.1186/s12885-021-08123-w Cite
The authors highlight the processes involved in CSCs development and maintenance as well as the current effective therapies based on stem cells, cell-free therapies that involve exosomes and miRNAs, and photodynamic therapy have been discussed.
The clinical importance of myelodysplastic syndromes (MDS) stem cells has been highlighted through the demonstration of selective persistence of MDS stem cells in patients at complete remission in response to therapy.
[Journal of Internal Medicine]
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Woll, P. S., & Jacobsen, S. E. W. (n.d.). Stem cell concepts in myelodysplastic syndromes: lessons and challenges. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13283 Cite
A tumor‐microenvironment‐responsive hydrogel patch was designed to modulate the plasticity of tumor‐initiating cells in triple‐negative breast cancer, which is insensitive to hormone‐ and HER2‐targeting.
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Ji, X., Guo, D., Ma, J., Yin, M., Yu, Y., Liu, C., Zhou, Y., Sun, J., Li, Q., Chen, N., Fan, C., & Song, H. (n.d.). Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer. Advanced Materials, n/a(n/a), 2100949. https://doi.org/https://doi.org/10.1002/adma.202100949 Cite
Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
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Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
Investigators used breast cancer as an example of the origins of tumor heterogeneity and of tumor cell plasticity, as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity.
[British Journal of Cancer]
The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
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Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
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Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
Investigators identified that both ectopic wild type and nonISGylatable mutant interferon‐stimulated gene 15 (ISG15) expression inhibited CSC‐like phenotypes of cisplatin‐resistant ovarian cancer cells.
[Journal of Cellular and Molecular Medicine]
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Zhang, Q., Wang, J., Qiao, H., Huyan, L., Liu, B., Li, C., Jiang, J., Zhao, F., Wang, H., & Yan, J. (n.d.). ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell-like features in cisplatin-resistant ovarian cancer. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16503 Cite
Researchers made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse.
[Experimental Biology and Medicine]