Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Effects of Iron Modulation on Mesenchymal Stem Cell-Induced Drug Resistance in Estrogen Receptor-Positive Breast Cancer

[Oncogene] The authors utilized a co-culture model of bone marrow mesenchymal stem cells and estrogen receptor+ breast cancer cells to recapitulate interactions of cancer cells in bone marrow niches.

HERVs Characterize Normal and Leukemia Stem Cells and Represent a Source of Shared Epitopes for Cancer Immunotherapy

[American Journal of Hematology] Researchers used a reference of 14,968 human endogenous retroviruses (HERV) functional units to provide a thorough analysis of HERV expression in normal and acute myeloid leukemia bone marrow cells.

Toll-Like Receptor 2 Promotes Breast Cancer Progression and Resistance to Chemotherapy

[Oncoimmunology] Scientists showed that high TLR2 expression is linked to poor prognosis in breast cancer patients, therefore representing a candidate target for breast cancer treatment.

Garcinone C Suppresses Tumorsphere Formation and Invasiveness by Hedgehog/Gli1 Signaling in Colorectal Cancer Stem-Like Cells

[Journal of Agricultural and Food Chemistry] Researchers investigated the effect of garcinone C on cancer stemness and invasiveness in colorectal cancer; Gli1 was noted as pivotal in maintaining stemness and invasiveness in HCT116 and HT29 CSCs.

Cancer Stem Cell-Like Cells-Derived Exosomal CDKN2B-AS1 Stabilizes CDKN2B to Promote the Growth and Metastasis of Thyroid Cancer via TGF-β1/Smad2/3 Signaling

[Experimental Cell Research] Scientists investigated the role of cancer stem cell-like cells-derived exosomal CDKN2B-AS1 in thyroid cancer and the underlying regulatory mechanism.

CDC20 Regulates Sensitivity to Chemotherapy and Radiation in Glioblastoma Stem Cells

[PLoS One] CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim.

Targeting CXCR4 to Suppress Glioma-Initiating Cells and Chemoresistance in Glioma

[Cell Biology International] The authors indicated that CXCR4 mediated the upregulation of Kruppel like factor 5, a zinc-finger-containing transcription factor, to facilitate the proliferation of glioma initiating cells.

Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction

[Computational and Mathematical Methods in Medicine] The authors identified the antitumourigenic activities of the medicinal compound chelerythrine chloride (CHE) on melanoma CSCs. CHE induced apoptosis in A375 and A2058 CSCs.

Stem Cell Theory of Cancer: Origin of Metastasis and Sub-Clonality

[Seminars in Diagnostic Pathology] Investigators discuss whether stem-ness enables metastasis or mutations drive metastasis. They ponder about low-grade versus high-grade tumors and about primary versus metastatic tumors.

CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

[Science Translational Medicine] Researchers studied the role of cyclin-dependent kinase regulatory subunit 1 (CKS1)–dependent protein degradation in primary human acute myeloid leukemia and healthy hematopoiesis xenograft models in vivo.

Exploring Stem Cell Biology in Pituitary Tumors and Derived Organoids

[Endocrine-Related Cancer] In human pituitary tumors, cells typified by expression of stemness markers, in particular SOX2 and SOX9, were found present in a wide variety of clinical tumor types, also showing a pronounced proliferative status.

Oct4A Palmitoylation Modulates Tumorigenicity and Stemness in Human Glioblastoma Cells

[Neuro-Oncology] The expression of Oct4 variants was evaluated in brain cancer cell lines, and in brain tumor tissues, by quantitative real-time PCR, western blotting, and immunohistochemical analysis.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.