Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Sleep Exerts Lasting Effects on Hematopoietic Stem Cell Function and Diversity

[Journal of Experimental Medicine] Researchers showed that sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells and increased their proliferation, thus reducing hematopoietic clonal diversity through accelerated genetic drift.

Splenic Red Pulp Macrophages Provide a Niche for CML Stem Cells and Induce Therapy Resistance

[Leukemia] Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contribute to disease progression.

Snail Maintains the Stem/Progenitor State of Skin Epithelial Cells and Carcinomas through the Autocrine Effect of Matricellular Protein Mindin

[Cell Reports] In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.

Faculty Earn State Grants for Cancer Research

[University of Texas] The Cancer Prevention and Research Institute of Texas has released three grant research funding awards to research projects at the University of Texas at Austin College of Pharmacy.

Intra-Tumor Heterogeneity of Cancer Stem Cell-Related Genes and Their Potential Regulatory MicroRNAs in Metastasizing Colorectal Carcinoma

[Oncology Reports] The expression gradient of four genes related to CSCs and their potential regulatory microRNAs were investigated in the central part and invasive front of the primary tumor, as well as in lymph node and liver metastases.

SerpinB3 Drives Cancer Stem Cell Survival in Glioblastoma

[Cell Reports] Knockdown of SerpinB3 increased apoptosis and susceptibility to radiation therapy, and scientists found that SerpinB3 was essential to buffer cathepsin L-mediated cell death.

CCR3 Blockage Elicits Polyploidization Associated with the Signatures of Epithelial-Mesenchymal Transition in Carcinoma Cell Lines

[Cancer Gene Therapy] Researchers explored the blockage of chemokine receptor CCR3 in carcinoma cell lines and found that inhibition of CCR3 induced the formation of polyploid giant cells and stabilization of β-catenin via the PI3K/Akt/GSK-3β signaling pathway.

Cancer Stem Cells Induced by Chronic Stimulation with Prostaglandin E2 Exhibited Constitutively Activated PI3K Axis

[Scientific Reports] Investigators assessed prostaglandin E2 (PGE2) as a candidate for the ability to induce CSCs from iPSCs, and chronic stimulation of the receptors EP-2/4 by PGE2 was supposed to induce CSCs from iPSCs through epigenetic effect.

An Anti-Alcoholism Drug, Disulfiram and Copper Complex Improves Radio-Resistance of Tumor-Initiating Cells in Esophageal Squamous Cell Carcinoma

[Esophagus] Scientists investigated the effect of disulfiram and copper (II) D-gluconate on the radiosensitivity of esophageal squamous cell carcinoma in xenograft mouse models.

Snail Maintains the Stem/Progenitor State of Skin Epithelial Cells and Carcinomas through the Autocrine Effect of Matricellular Protein Mindin

[Cell Reports] In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.

Single-Cell Transcriptome Reveals Cellular Hierarchies and Guides P-EMT-Targeted Trial in Skull Base Chordoma

[Cell Discovery] Combining radiated UM-Chor1 RNA-seq data and in vitro validation, researchers found clusters of stem-like skull base chordoma cells were marked by cathepsin L, a gene involved in the packaging of telomere ends, and which may be responsible for radioresistance.

TWIST1 Induces Proteasomal Degradation of β-Catenin During the Differentiation of Ovarian Cancer Stem-Like Cells

[Scientific Reports] Researchers demonstrated that β-catenin is regulated by the protein degradation system in mesenchymal spheroid-forming cells and secondary epithelial ovarian cancer cells, but not in primary epithelial ovarian cancer cells.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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