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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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CD8+ T Cell Stemness Precedes Post-Intervention Control of HIV Viremia
[Nature] Scientists mapped and functionally profiled CD8+ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in broadly neutralizing anti-HIV-1 antibody (bNAb) recipients. CD8+ T cell stemness was further increased following bNAb administration without the emergence of new clonotypes targeting defined HLA-optimal epitopes.
Targeting Leukemic Stem Cell Biomechanics Suppresses Stemness and Enhances NK Cell-Mediated Immunotherapy
[Nature Communications] Single-cell RNA-sequencing of primary human acute myeloid leukemia bone marrow identifies enrichment of leukemic stem cells within the FSClow ALDH1A1+ subpopulation, which exhibits long-term stemness in functional assays.
Efferocytosis-Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer
[Advanced Science] Researchers showed that efferocytosis and associated polyamine metabolic reprogramming support the chemotherapy-induced enrichment of CSCs, providing new targets for addressing chemoresistance and recurrence of ovarian cancer.
Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme a to Abrogate the Differentiation of CD103 + T Cells
[Advanced Science] Investigators demonstrated that CSCs play a pivotal role in suppressing CD103+ T cell differentiation in patients with non-small cell lung cancer.
Targeting Cancer Stem-Like Cells via Cholesterol Modulation and Ferroptosis Induction Using a Multifunctional Nanoplatform to Overcome Drug Resistance
[Journal of Nanobiotechnology] In triple-negative breast cancer mouse models, Fe/CDP selectively targets tumors and CSCs via CD44-chondroitin sulfate interactions, enabling localized drug release.
Cisplatin-Mediated Activation of NF-κB Promotes Lung Cancer Stem Cell Formation via DNA Repair Pathways
[Journal of Translational Medicine] Scientists elucidated the mechanisms underlying cisplatin resistance, with a focus on the role of DNA repair pathways and CSCs in NSCLC.
Acetylated KLF5 Inhibits LACTB Transcription, Mediates Mitochondrial Dynamics, and Regulates Colorectal Cancer Cell Stemness, and Differentiation
[International Journal of Biological Macromolecules] Researchers investigated the role of serine beta-lactamase-like protein (LACTB) in colorectal cancer cell stemness and differentiation. They assessed LACTB expression levels by analyzing data from database and our collected CRC samples.
CD271 Targeted Near-Infrared Photoimmunotherapy for Local Depletion of Cancer Stem Cells
[Molecular Pharmaceutics] Investigators demonstrated the efficacy of CD271-targeted near-infrared photoimmunotherapy, which is believed will have a significant impact on the future development of cancer stem cell-targeted therapy.
Shen-Bai-Jie-Du Decoction Inhibits Colorectal Tumorigenesis by Attenuating the Malignancy of Cancer Stem Cells via the Gut Microbiota-Bile Acid-FXR Axis
[Phytomedicine] Scientists elucidated the mechanism through which Shen-Bai-Jie-Du decoction suppresses colorectal CSC aggressiveness by modulating the gut microbiota-bile acid-Farnesoid X receptor (FXR) signaling axis.
Liver Cancer Stem Cells As Novel Diagnostic Biomarkers
[Clinica Chimica Acta] The authors synthesize current findings on the molecular characterization of liver cancer stem cells (LCSCs), their clinical relevance, and the potential integration of LCSC biomarkers into precision oncology workflows.
Nanomedicine and Nutraceutical-Based Nanocarriers for Specific Delivery to Cancer Stem Cells: Targeted Drug Delivery at the STEM Frontier
[Discover Oncology] Scientists explore the synergistic potential of combining advanced nanocarriers with potent nutraceuticals, emphasizing their capacity to modulate critical CSC signaling pathways and overcome inherent bioavailability challenges.
Quetzal Therapeutics Launches Phase III Clinical Trial of Oral QTX-2101 for Acute Promyelocytic Leukemia (APL)
[Quetzal Therapeutics (Globe Newswire)] Quetzal Therapeutics announced the initiation of a pivotal Phase III clinical trial of QTX-2101. The trial will evaluate the efficacy, safety, and pharmacokinetics of QTX-2101, as a potential new treatment for APL, a rare and aggressive blood cancer.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
