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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Tailoring a Novel Colorectal Cancer Stem Cell-Targeted Therapy by Inhibiting the SMYD3/C-MYC Axis
[Signal Transduction and Targeted Therapy] Researchers performed an extensive in vitro and in vivo molecular and functional characterization, revealing the pivotal role of the lysine methyltransferase SET and MYND Domain Containing 3 (SMYD3) in colorectal CSC biology.
Cancer Stem Cells-Derived Exosomal TSPAN8 Enhances Non-Stem Cancer Cells Stemness and Promotes Malignant Progression in PDAC
[Oncogene] Investigators employed single-cell RNA sequencing and exosomal profiling, identifying TSPAN8-enriched exosomes secreted by CSC, which are associated with poor survival rates in pancreatic ductal adenocarcinoma patients.
SLC27A5 Inhibits Cancer Stem Cells by Inducing Alternative Polyadenylation of METTL14 in Hepatocellular Carcinoma
[Genes & Diseases] SLC27A5/PABPC1 inhibits hepatocellular carcinoma stemness via alternative polyadenylation-regulated expression of METTL14, providing potential avenues for the development of novel therapeutic strategies.
ARID3A Inhibits Colorectal Cancer Cell Stemness and Drug-Resistance by Targeting a Multitude of Stemness-Associated Genes
[Life Sciences] Scientists demonstrated that ARID3A inhibits CRC stemness, anchorage-independent growth, self-renewal, anti-cancer drug resistance of CRC cells, and tumor growth in vivo.
AXL Enhances the Self-Renewal of Cancer Stem-Like Cells and Osimertinib Chemoresistance by Regulating SCD1 in Non-Small Cell Lung Cancer
[Biochemical Pharmacology] Scientists provide new insights into the role and mechanism of AXL in regulating the stemness of non-small cell lung cancer CSCs. Their study also gives a new hint for the relationship between AXL and SCD1.
Hematopoietic Stem Cell Conditioned Media Induces Apoptosis in Colorectal Cancer Stem Cells Via Dysregulation of HSP90 and 26S Proteasome System
[The International Journal of Biochemistry & Cell Biology] Investigators used hematopoietic stem cells (HSCs) and HSCs-derived conditioned media (CM) to target colorectal cancer stem cells. Their findings provide the prospective targeting of cancer stem cells using HSCs-CM, indicating a possible therapeutic approach.
Anticancer Potential of Myricetin Against Huh7- and Hep3B-Derived Liver Cancer Stem Cells Through the Regulation of Apoptosis, Autophagy, and Stemness
[Biomolecules & Therapeutics] Investigators evaluated the effects of myricetin on liver cancer stem cells (LCSCs) derived from Huh7 and Hep3B cell lines, both in vitro and in vivo. LCSCs were treated with myricetin to assess cell proliferation, cell cycle arrest, apoptosis induction, autophagy regulation, stemness, EMT marker expression, and tumor growth suppression using a chicken embryo CAM model.
TET3 Facilitates Bladder Cancer Progression through Targeted Modulation of Stemness Pathways
[Medical Oncology] Scientists analyzed single-cell RNA sequencing data and identified TET3 as a key regulator in tumor-promoting cells using scissor analysis.
Lipid Metabolism in Cancer Stem Cells: Reprogramming, Mechanisms, Crosstalk, and Therapeutic Approaches
[Cellular Oncology] The authors underscore the emerging significance of lipid metabolism as both a hallmark and vulnerability of CSCs, offering opportunities for novel targeted cancer therapies.
Revolution Medicines Announces FDA Breakthrough Therapy Designation for Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer with KRAS G12 Mutations
[Revolution Medicines, Inc.] Revolution Medicines, Inc. announced that the US FDA has granted Breakthrough Therapy Designation to daraxonrasib, the company’s RAS(ON) multi-selective inhibitor, for previously treated metastatic PDAC in patients with KRAS G12 mutations.
A Nanovaccine Targeting Cancer Stem Cells and Bulk Cancer Cells for Postoperative Cancer Immunotherapy.
[Nature Nanotechnology] Researchers proposed a nanovaccine strategy, called NICER, based on a nanovesicle system integrating CSC-specific antigen display and epigenetic nano-regulator encapsulation with a dendritic-cell-targeting aptamer, to simultaneously eradicate CSCs and bulk tumour cells.
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.
[Cancer Research] Investigators suggested that class III phosphoinositide 3-kinase-peripheral lysosomal signaling to mTORC1 may represent a targetable axis for preventing dormant cancer cell–initiated metastasis in patients with breast cancer.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
