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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Microenvironmental Regulation of Solid Tumor Resistance to CAR T Cell Therapy
[Nature Reviews Immunology] One of the initial obstacles that CAR T cells encounter is the abnormal tumour vasculature, which restricts efficient T cell infiltration, further compounded by a dense extracellular matrix.
Parkinson’s Treatment Tested at UW Showing Promise in First Clinical Trial
[University of Wisconsin–Madison] Parkinson’s patients are receiving a new investigational treatment after a successful study at the University of Wisconsin–Madison (UW) helped demonstrate the cell therapy’s safety in non-human primates and refine the method for its delivery.
Developing SEMA4A-Directed CAR T Cells to Overcome Low BCMA Antigen Density in Multiple Myeloma
[Cancer Cell] Investigators quantitatively profile antigen density in a cohort of patients relapsed after B cell maturation antigen (BCMA) CAR T therapy, showing high number of SEMA4A molecules/cell where BCMA density is low.
Fine Tuning Towards the Next Generation of Engineered T Cells
[Nature Biomedical Engineering] Scientists discuss the multifaceted exploration of CAR T cell engineering approaches and emerging directions, highlighting the available strategies that can be built on to create the next generation of cellular therapies.
Solid Tumor CAR-T Cells Engineered with Fusion Proteins Targeting PD-L1 for Localized IL-12 Delivery
[Nature Biomedical Engineering] Scientists engineered CAR-T cells to secrete TGFβtrap, IL-15, or IL-12 molecules fused to αPD-L1 scFv and assessed in vitro functionality and in vivo safety and efficacy in prostate and ovarian cancer models. '
Comparative Analysis of RNA Versus Protein Splicing in Dual AAV-Mediated Gene Therapy in a Mouse Model of DFNB9 Deafness
[Molecular Therapy] To investigate the impact of different recombination strategies on the efficacy of OTOF gene therapy, the authors constructed five dual-AAV1 therapeutic agents using RNA or protein splicing principles.
Bedside Manufacturing of Engineered Stem Cells Using Gene Therapy Foam
[Molecular Therapy-Methods & Clinical Development] Reseachers described a bedside cell manufacturing strategy in which hematopoietic stem cells are genetically targeted within gene therapy foam that is mixed with freshly isolated bone marrow aspirate concentrate and then directly injected back into the marrow.
Low Dose Naloxone Mitigates Opioid Tolerance and Dependence and Restores Mesenchymal Stem Cell Function for Cell Therapy in Addiction
[Scientific Reports] Investigators evaluated the morphine effects on the properties of bone marrow mesenchymal stem cells in morphine-dependent rats and assess the potential of low-dose naloxone in counteracting the adverse effects.
Optimizing CAR T Cell Therapy for Solid Tumours: A Clinical Perspective
[Nature Reviews Clinical Oncology] The authors discuss advanced response evaluation frameworks that will be essential for accurate assessment of the efficacy of CAR T cell therapies and highlight the need for robust toxicity management approaches to mitigate severe adverse events.
Kincell Bio Announces Strategic Collaboration with Major Academic Medical Center to Advance Cell and Gene Therapy Innovation
[Kincell Bio Inc.] Kincell Bio Inc. announced the signing of a memorandum of understanding with the Duke University School of Medicine. The collaboration is designed to accelerate innovation in cell and gene therapy research, strengthen translational pathways, and support the development of scalable and efficient manufacturing solutions for advanced biologics.
Development of an Adeno-Associated Virus Vector for Gene Replacement Therapy of NF1-Related Tumors
[Nature Communications] Researchers introduced a membrane-targeted, truncated neurofibromin comprising the GAP-related domain fused to the KRAS4B C-terminal domain, which effectively inhibits the RAS signaling pathway and restores Schwann cell differentiation in an NF1 iPSC-derived model.
IDR-Induced CAR Condensation Improves the Cytotoxicity of CAR-Ts against Low-Antigen Cancers
[Nature Chemical Biology] Scientists engineered CARs targeting CD19, CD22, and HER2 by including intrinsically disordered regions (IDRs) that promote signaling condensation.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
