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Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
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Microglia Replacement by Peripheral Delivery of CSF1R Inhibitor-Resistant Hematopoietic Cells
[Molecular Therapy] The authors introduced a transgenic mouse line carrying the homologous murine inhibitor resistance mutation, G793A. G793A confers resistance to CSF1R inhibitors (CSF1Ris) without impacting cell or organismal function.
Engineered CXCR3-A Expression Enhances B7-H3-Targeting CAR T Cell Migration and Efficacy against Diffuse Intrinsic Pontine Glioma
[Nature Communications] Investigators showed that, compared to unmodified B7-H3 CAR T cells, CXCR3-A-modified CAR T cells migrate more efficiently toward CXCR3 ligands in vitro.
HBsAg-Tagged Tumor Vaccine System Eliminates Solid Tumours through Virus-Specific Memory T Cells
[Nature Biomedical Engineering] Researchers developed a hepatitis B surface antigen (HBsAg)-tagged tumour vaccine system (H-TVAC). H-TVAC leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumour cells using the vaccinia virus.
Novel Allogeneic CAR T Cell Platform Involving Microhomology-Mediated End Joining Repair and Low Off-Targeting Potential
[Molecular Therapy - Nucleic Acids] The authors developed a novel CRISPR RNA (crRNA) targeting the T-cell receptor beta constant gene. Combined with AsCas12a Ultra, this crRNA edits primary human T-cells via a predictable microhomology-mediated end joining DNA repair pathway, significantly lowering off-target risks.
Low Reticulocyte Count at Infusion Is a Risk Factor for High-Grade Cytokine Release Syndrome in Chimeric Antigen Receptor T Cell Therapy
[International Journal of Hematology] To identify risk factors for high-grade cytokine release syndrome, the authors retrospectively analyzed B-cell lymphoma patients who received CD19 CAR-T cell therapy.
Intrinsic NPRL2 and NPRL3 Regulate the Sensitivity of B-Cell Malignancies to CAR-T Cell Therapy
[Journal of Genetics and Genomics] Building on CRISPR/Cas9 genome-wide screening in malignant B-cells, scientists identified NPRL2 and NPRL3 as key regulators of tumor sensitivity to CAR-T cytotoxicity.
Gene Therapy for Hemoglobinopathies: Clinical Trial Results and Biology of Hematopoietic Stem Cell and the Bone Marrow Niche
[Cell Reports Medicine] Investigators review the clinical application of gene therapy by gene addition and gene editing, and the novel findings about hematopoietic stem cell and bone marrow niche features and function in hemoglobinopathies.
Washington Research Foundation Awards $5.2M to Establish New Clinical Trials Program
[Fred Hutchinson Cancer Center] A new $5.2 million grant from the Washington Research Foundation will help develop a new clinical trials program between Fred Hutch Cancer Center and Seattle Children’s Research Institute.
With $3M Grant, uOttawa Medical Scientist Leads Pioneering Cancer Immunotherapy Research
[University of Ottawa] Backed by a prestigious $3M Terry Fox New Frontiers Program Project Grant, Dr. Michele Ardolino and team will seek to uncover the hidden mechanisms of how the body’s immune system, nervous system, and gut microbiome interact in cancer,
Extracellular Vesicle-Mediated Gene Editing for the Treatment of Nonsyndromic Progressive Hearing Loss in Adult Mice
[Science Translational Medicine] Scientists developed a microfluidic droplet–based extracellular vesicle (EV) electroporation system called μDES to efficiently load single-guide RNA:CRISPR–associated protein 9 ribonucleoprotein complexes into EVs.
Gene Therapy CM-YAPon Protects the Mouse Heart from Myocardial Infarction
[Nature Cardiovascular Research] Investigators developed an adeno-associated virus 9-based therapy, termed CM-YAPon, which enables transient expression of an active YAP variant in cardiomyocytes after exposure to the small molecule LMI070.
Discovery and Engineering of Retrons for Precise Genome Editing
[Nature Biotechnology] Scientists reported the discovery and engineering of highly efficient retron-based gene editors for mammalian cells and vertebrates. Through bioinformatic analysis of metagenomic data and functional screening, they identified retron reverse transcriptases that are highly active in mammalian cells.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
