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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria-Mediated Sterile Inflammation
[Advanced Science] Researchers described a blood–brain barrier (BBB) microphysiological system that allows to explore the responses of BBB and distinct brain cells to radiation exposure.
Engineering In Vitro Vascular Microsystems
[Microsystems & Nanoengineering] The authors highlights advanced engineering strategies for in vitro vascular microsystems, covering the domains related to rational designs, manufacturing approaches, supporting materials, and organ-specific cell types.
Brain Drugs Can Now Cross the Once Impenetrable Blood-Brain Barrier
[Nature] New technologies to shuttle drugs into the brain are showing promise in Alzheimer’s disease, cancer, and more.
Immune Cell Infiltration into Brain Tumor Microenvironment Is Mediated by Rab27-Regulated Vascular Wall Integrity
[Science Advances] In Rab27a/b double knock outmice, the brain vasculature is abnormally scarce, while the blood vessels become dysmorphic and hyperpermeable in the context of brain tumors, including syngeneic glioblastoma.
Engineered Vasculature Induces Functional Maturation of Pluripotent Stem Cell-Derived Islet Organoids
[Developmental Cell] Scientists engineered three-dimensional vascularized stem cell (SC)-islet organoids by assembling SC-islet cells, human primary endothelial cells, and fibroblasts in a non-perfused model and a microfluidic device with perfused vessels.
Mitochondrial Transfer in Endothelial Cells and Vascular Health
[Trends in Cell Biology] Endothelial cells acquire mitochondria via tunneling nanotubes and extracellular vesicles, enhancing resilience under stress and promoting vascular repair.
DNA Dioxygenase TET2 Deficiency Aggravates Sepsis-Induced Acute Lung Injury by Targeting ITGA10 via the PI3K/AKT Signaling Pathway
[Cellular & Molecular Biology Letters] Investigators demonstrated that ten-eleven translocation protein 2 (TET2) deficiency aggravates endothelial cell dysfunction and promotes acute lung injury by targeting Integrin α10 (ITGA10) via the PI3K-AKT pathway.
PRL3-Zumab As an Anti-Angiogenic Therapy in Neovascular Eye Diseases
[Nature Communications] The authors reported the specific upregulation of endogenous phosphatase of regenerating liver 3 (PRL3) protein in diseased choroid-RPE in choroidal neovascularization mouse model, and diseased retina in oxygen-induced retinopathy mouse model, indicating PRL3’s role in neovascularization.
Angiopoietin-TIE2 Feedforward Circuit Promotes PIK3CA-Driven Venous Malformations
[Nature Cardiovascular Research] In Pik3caH1047R-driven venous malformations mouse models, single-cell transcriptomics and lineage tracking revealed clonal expansion of mutant endothelial cells with a post-capillary venous phenotype, characterized by suppression of the AKT-inhibited FOXO1 and its target genes.
FDA Approves Roche’s Susvimo for Diabetic Retinopathy
[Roche] Roche announced that the US FDA has approved Susvimo® 100 mg/mL for the treatment of diabetic retinopathy, a potentially blinding condition that affects almost 10 million people in the US and more than 100 million people globally.
Dual Exosome Coating for Modulating Endothelial Function and InflammationArticle link copied!
[ACS Applied Materials & Interfaces] A dual exosome coating was fabricated to promote endothelial function and macrophage efferocytosis via a synergistic effect by endothelial cell-sourced and mesenchymal stem cell-sourced exosomes.
Adaptation of Mitochondrial Bioenergetics to Coenzyme Q Deficiency in Human Endothelial Cells after Chronic Exposure to Bisphosphonates
[Scientific Reports] Researchers examined the effects of chronic six-day exposure of human endothelial cells to nitrogen-containing bisphosphonates on mitochondrial bioenergetic functions, focusing on drug-induced mitochondrial CoQ deficiency.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
