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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Unveiling the Protective Role of ESM1 in Endothelial Cell Proliferation and Lipid Reprogramming
[Scientific Reports] A mouse model of atherosclerosis was used to observe the effect of palmitic acid on the endothelial cell-specific molecule 1 (ESM1)-angiopoietin-like 4 (ANGPTL4)-autophagy signaling axis. Scientists reported that ESM1 facilitates endothelial cell proliferation and lipids homeostasis by up-regulating autophagy through ANGPTL4.
Acetylation of α-Tubulin Restores Endothelial Cell Injury and Blood-Brain Barrier Disruption after Intracerebral Hemorrhage in Mice
[Experimental & Molecular Medicine] Researchers investigated the role of acetylated α-tubulin in blood–brain barrier integration after intracerebral hemorrhage.
Endothelial Cell Metabolism in Cardiovascular Physiology and Disease
[Nature Reviews Cardiology] The authors discuss the diversity of metabolic programmes that control endothelial cell function in the cardiovascular system and how these metabolic programmes are perturbed in different cardiovascular diseases in a disease-specific manner.
Meningeal Lymphatic Drainage: Novel Insights into Central Nervous System Disease
[Signal Transduction and Targeted Therapy] Scientists provide direction for future research and therapeutic strategies targeting meningeal lymphatics by critically analyzing recent advancements in the field, identifying gaps in current knowledge, and proposing innovative approaches to address these gaps.
Bispecific vs. Bispecific: Innovent Announces First Patient Dosed in the Phase II Clinical Study of Efdamrofusp Alfa, a First-In-Class Anti-VEGF and Anti-Complement Bispecific Fusion...
[Innovent Biologics, Inc.] Innovent Biologics, Inc. accounced the completion of first patient dosing in the Phase II clinical study of efdamrofusp alfa, a recombinant human VEGFR-antibody human complement receptor 1 fusion protein, for the treatment of diabetic macular edema.
Typhoid Toxin Causes Neuropathology by Disrupting the Blood-Brain Barrier
[Nature Microbiology] Utilizing mice engineered to have specific tissues protected from toxin action and an in vitro model of the blood–brain barrier (BBB), researchers demonstrated that, rather than direct action on neuronal or glial cells, typhoid toxin causes neuropathology by disrupting the BBB.
Endothelial Major Vault Protein Alleviates Vascular Remodeling via Promoting Parkin-Mediated Mitophagy
[Nature Communications] The authors investigated the regulatory role of major vault protein in the pathogenesis of vascular remodeling via controlling endothelial cell injury.
Highly Conserved Brain Vascular Receptor ALPL Mediates Transport of Engineered AAV Vectors across the Blood-Brain Barrier
[Molecular Therapy] Researchers applied an RNA-guided TRACER adeno-associated virus (AAV) capsid evolution platform to generate VCAP-102, an AAV9 variant with markedly increased brain tropism following intravenous delivery in both rodents and primates.
DDX24 Spatiotemporally Orchestrates VEGF and Wnt Signaling during Developmental Angiogenesis
[Proceedings of The National Academy of Sciences of The United States of America] Investigators demonstrated the pivotal role of DEAD-box RNA helicase 24 (DDX24) in the regulation of vascular development in the brain and trunk. Ddx24 deficiency in zebrafish results in ectopic vessel sprouting in the trunk but inhibits angiogenesis in the brain.
Development of Small Tissue Engineered Blood Vessels and Their Clinical and Research Applications
[Biofabrication] Scientists describe the native structure and function of arteries, and provide an verview of different biomaterials, cells, and methods that have been used during the last years for the development of small tissue engineered blood vessels.
Competitive Inhibition of Ephrin-A1 and EphA2 Binding by Perillaldehyde Leads to Decreased TRPM2 Expression and Reduced Mitochondrial Damage in Vascular Endothelial Cells
[International Immunopharmacology] Scientists elucidated the molecular mechanisms underlying perillaldehyde-mediated endothelial protection through the establishment of endothelium-specific TRPM2 transgenic and knockout murine models.
Endothelial Dysfunction in Cardiovascular Diseases: Mechanisms and In Vitro Models
[Molecular and Cellular Biochemistry] The authors synthesize currently available in vitro models regarding endothelial cell dysfunction, emphasizing cardiovascular diseases. They focused on 2D cell culture models, 3D cell culture systems, and models.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
