ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Smad4 Is Essential for Epiblast Scaling and Morphogenesis after Implantation, but Nonessential Prior to Implantation in Mouse

[Development] Investigators showed that, in contrast to prior reports, bone morphogenic protein signaling (SMAD1/5/9 phosphorylation) is not detectable until implantation when it is detected in the primitive endoderm – an extraembryonic lineage.

GPR160 Regulates the Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells via JAK1/STAT3 Signal Pathway

[Journal of Genetics and Genomics] Scientists showed that GPR160, a class A member of G protein-coupled receptors, was dramatically downregulated concurrent with mESC differentiation into embryoid bodies in vitro.

Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways

[Nature Communications] Researchers demonstrated that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor or prime editor additively enhanced editing efficiency in hPSCs.

Combinatorial microRNA Activity Is Essential for the Transition of Pluripotent Cells from Proliferation into Dormancy

[Genome Research] Investigators showed that microRNA activity, which was otherwise dispensable for preimplantation development, was essential for the adaptation of early mouse embryos to the dormant state of diapause.

Arp2/3 Mediated Dynamic Lamellipodia of the hPSC Colony Edges Promote Liposome-Based DNA Delivery

[Stem Cells] Researchers used hPSCs which formed compact colonies consisting of dynamically active cells at the periphery and epithelial-like cells at the core.

A High-Throughput Screen in mESCs to Identify the Cross-Talk between Signaling, Endocytosis, and Pluripotency

[Cell Biology International] The authors collated a list of 1141 genes in connection to the term “endocytosis” from Kyoto Encyclopedia of Genes and Genomes and Gene Ontology and examined the effect of their knockdown on the pluripotency of mESCs using levels of green fluorescent protein driven by the Oct4 promoter.

The First Two Blastomeres Contribute Unequally to the Human Embryo

[Cell] Investigators performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast, hypoblast, and trophectoderm.

Osctillatory Control of Embryonic Developmen

[Development] Scientists describe the similarities and differences of the expression pattern in space and in time of mammalian Hes/zebrafish Her genes and their targets in different tissues.

Maryland Stem Cell Research Commission Announces $15.4 Million in Awards to Accelerate Cures

[Maryland Stem Cell Research Commission] The Maryland Stem Cell Research Commission announced the next round of awards granting a total of more than $15.4 million. These awards are aimed at fostering groundbreaking research to enhance and propel stem cell treatments and technologies across Maryland.

Single-Cell 3D Genome Structure Reveals Distinct Human Pluripotent States

[Genome Biology] By single-cell analysis of high-resolution, three-dimensional (3D) genomic structure, researchers demonstrated that remodeling of genomic structure was highly associated with the pluripotent states of hESCs.

Spontaneous Differentiation of Human Induced Pluripotent Stem Cells to Odorant-Responsive Olfactory Sensory Neurons

[Biochemical And Biophysical Research Communications] Researchers employed dual SMAD inhibition and fibroblast growth factor 8 along with N-2 and B-27 supplements in the culture medium to efficiently induce the differentiation of iPSCs into neuronal cells with olfactory function through olfactory placode.

Multiscale Chromatin Dynamics and High Entropy in Plant iPSC Ancestors Icon for the Forest of Biologists

[Journal of Cell Science] High-throughput imaging and a custom, supervised image analysis protocol extracting over 100 chromatin features unravelled a rapid, multiscale dynamics of chromatin patterns which trajectory strongly depends on nutrients availability.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.