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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Analyzing Embryo Dormancy at Single-Cell Resolution Reveals Dynamic Transcriptional Responses and Activation of Integrin-Yap/Taz Prosurvival Signaling
[Cell Stem Cell] Using mouse embryos and single-cell RNA sequencing, researchers molecularly defined embryonic diapause at single-cell resolution, revealing transcriptional dynamics while the embryo seemingly resided in a state of suspended animation.
β-Catenin Mediates Endodermal Commitment of Human ES Cells via Distinct Transactivation Functions
[Cell & Bioscience] The authors generated new CTNNB1-/- hESCs using CRISPR-based insertional gene disruption approach and systematically rescued the definitive endoderm defect in these cells by introducing various truncated or mutant forms of β-catenin.
SoxB1 Transcription Factors Are Essential for Initiating and Maintaining Neural Plate Border Gene Expression
[Development] Using Xenopus laevis, investigators determined whether SoxB1 transcription factors had a regulatory function in neural plate border formation.
Substrate Stiffness Alters Layer Architecture and Biophysics of Human Induced Pluripotent Stem Cells to Modulate their Differentiation Potential
[iScience] Scientists ivestigated the ability of hiPSCs to undergo lineage commitment in response to inductive signals and assessed how this competence was modulated by substrate stiffness.
Atelocollagen Supports Three-Dimensional Culture of Human Induced Pluripotent Stem Cells
[Molecular Therapy-Methods & Clinical Development] Atelocollagen beads were evaluated as a three-dimensional (3D) biomaterial to assist 3D culture in the establishment, expansion culture, and induced differentiation of iPSCs.
CUT&Tag Applied to Zebrafish Adult Tail Fins Reveals a Return of Embryonic H3K4me3 Patterns during Regeneration
[Epigenetics & Chromatin] Researchers provided a modified CUT&Tag protocol suitable for improved characterization and interrogation of changes in chromatin modifications during adult fin regeneration in zebrafish.
Revealing the UV Response of Melanocytes in Xeroderma Pigmentosum Group a Using Patient-Derived Induced Pluripotent Stem Cells
[Journal of Dermatological Science] iPSCs were established from Xeroderma pigmentosum-A (XP-A) fibroblasts and differentiated into melanocytesb (MCs). Differences in gene expression profiles between XP-A-iPSC-derived melanocytes and Healthy control iPSC-derived MCs were analyzed 4 and 12 hours after irradiation.
Engineering of Gelatin Scaffold by Extracellular Matrix of Sertoli Cells for Embryonic Stem Cell Proliferation
[Toxicology in Vitro] Researchers fabricated electrospun gelatin mats conditioned with Sertoli cells' extracellular matrix to simulate both 3D structures and composition of normal testis tissue.
Purification Technologies for Induced Pluripotent Stem Cell Therapies
[Nature Reviews Bioengineering] Investigators discuss the latest applicable cell purification methods for clinical preparations, encompassing both current technologies that have been used in clinical settings and emerging state-of-the-art approaches that promise even greater potential.
Emergence of Large-Scale Cell Death through Ferroptotic Trigger Waves
[Nature] The authors demonstrated that ferroptosis, an iron- and lipid-peroxidation-dependent form of cell death, could propagate across human cells over long distances at constant speeds through trigger waves of reactive oxygen species.
Mapping the Chromatin Accessibility Landscape of Zebrafish Embryogenesis at Single-Cell Resolution by SPATAC-Seq
[Nature Cell Biology] Using SPATAC-seq, scientists profiled chromatin accessibility in more than 800,000 individual nuclei across 20 developmental stages spanning the sphere stage to the early larval protruding mouth stage.
Long-Term Culture of Human Pluripotent Stem Cells in Xeno-Free Condition Using Functional Polymer Films
[Advanced Materials] Scientists engineered a fully synthetic, xeno-free culture substrate, whose surface composition was tailored systematically for xeno-free culture of hPSCs.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
