ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Subscribe|Follow Us On

Enhancement of Hepatic Differentiation from Induced Pluripotent Stem Cells by Suppressing Epithelial-Mesenchymal Transition

June 6, 2025

[Hepatology Communications] Scientists optimized the differentiation protocol by addition of a combination of small molecules to inhibit epithelial–mesenchymal transition in iPSC-derived hepaticytes, and further characterized their function both in vitro and in vivo analyses.

ELTD1 Inhibits Differentiation of Hemogenic Endothelium Progenitors from Human Embryonic Stem Cells through the HPIP-Wnt Pathway

June 4, 2025

[Experimental & Molecular Medicine] Through dynamic gene expression profiling analysis and verification, scientists found that ELTD1 expression parallels genes related to the specification of hemogenic endothelium progenitors (HEPs) from hESCs and is highly expressed in the HEPs.

H3.3 Deposition Counteracts the Replication-Dependent Enrichment of H3.1 at Chromocenters in Embryonic Stem Cells

June 4, 2025

[Nature Communications] Scientists investigated the nuclear distribution of H3.1 and H3.3 variants, focusing on their relative enrichment at chromocenters throughout the cell cycle and in different cellular states.

Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells

May 28, 2025

[Stem Cells] Scientists deleted the whole genomic region of the m⁶A reader YTHDF2 and discovered that YTHDF2 is dispensable for the maintenance, but important for the differentiation of hESCs, especially for the differentiation towards ectoderm.

p53-Inducible lncRNA LOC644656 Causes Genotoxic Stress-Induced Stem Cell Maldifferentiation and Cancer Chemoresistance

May 28, 2025

[Nature Communications] Researchers identified the p53-induced long non-coding RNA LOC644656 as a key regulator of genotoxic stress-induced stem cell maldifferentiation in hESCs.

Shaking Culture Attenuates Circadian Rhythms in Induced Pluripotent Stem Cells during Osteogenic Differentiation through the TEAD-Fbxl3-CRY Axis

May 28, 2025

[Cell Death Discovery] Scientists investigated the effects of shaking cultures on the circadian rhythm of key clock genes in iPSC-embryoid bodies.

Stem Cell Models of Human Embryo Implantation and Trophoblast Invasion

May 28, 2025

[Current Opinion In Genetics & Development] The authors review how embryo and placenta models built from naïve stem cells can be leveraged to obtain mechanistic insights into human implantation and trophoblast invasion.

IGF2BP1 Restricts the Induction of Human Primordial Germ Cell Fate in an M6a-Dependent Manner

May 28, 2025

[Cell Stem Cell] Investigators reported that a knockout of m⁶A writers or overexpression of m⁶A erasers leads to an increased percentage of human primordial germ-like cells induced from ESCs using a 3D aggregate system.

UniXell Biotechnology Announces the First Patient Dosed with UX-DA001, an Investigational Autologous iPSC Based Cell Therapy for the Treatment of Parkinson’s Disease, in Its...

May 28, 2025

[UniXell Biotech (BioSpace)] Shanghai UniXell Biotechnology Co., Ltd. (UniXell Biotech) announced the successful first administration of its proprietary Parkinson's disease cell drug UX-DA001 in China.

Applied StemCell Launches Two New Hypoimmunogenic hiPSC Products to Accelerate Allogeneic Cell Therapy Development

May 28, 2025

[Applied StemCell] Applied StemCell announced the launch of their first hypoimmunogenic hiPSC products which are designed to empower researchers developing next-generation allogeneic cell therapies.

Cellino’s iPSC Manufacturing Technology Receives FDA Advanced Manufacturing Technology (AMT) Designation

May 28, 2025

[Cellino (BioSpace)] Cellino announced that its optical biomanufacturing technology for generating iPSCs has received the FDA’s AMT designation from the Center for Biologics Evaluation and Research.

Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells

May 26, 2025

[Stem Cell Reports] Scientists investigated the immediate consequences of inducing aneuploidy in hPSCs and the long-term fate of mosaic aneuploid and diploid populations.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.