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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Small Molecule- and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells
[Development] Researchers presented an approach for rapid engineering of multiple inducible systems into mESCs. Small molecule- and cell contact-inducible systems work reliably and efficiently for controlling expression of arbitrary genetic payloads.
Iterative Transcription Factor Screening Enables Rapid Generation of Microglia-Like Cells from Human iPSC
[Nature Communications] Scientists reported an iterative, high-throughput single-cell transcription factor screening method that enables the identification of transcription factor combinations for specialized cell differentiation, which they validated by differentiating human microglia-like cells.
The HP1 Box of KAP1 Organizes HP1α for Silencing of Endogenous Retroviral Elements in Embryonic Stem Cells
[Nature Communications] Investigators showed that binding of KRAB-associated protein 1 (KAP1) to the major component of the heterochromatin spreading and maintenance network, HP1α, plays a critical role in silencing of repetitive elements.
Efficient Generation of Germline Chimeras in a Non-Rodent Species Using Rabbit Induced Pluripotent Stem Cells
[Nature Communications] The authors demonstrated that rabbit iPSCs can be reprogrammed using KLF2, ERAS, and PRMT6, enabling them to efficiently colonize embryos.
Neowise Biotechnology and BeOne Medicines Enter Licensing Agreement to Advance Development of Next-Generation Cell Therapies
[Neowise Biotechnology (BioSpace)] Neowise Biotechnology announced that it has entered into a non-exclusive licensing agreement with BeOne Medicines Ltd. Under the terms of the agreement, Neowise will grant BeOne rights to one of its proprietary antigen-specific TCR molecules for the development of next-generation, iPSC-based off-the-shelf cell therapies.
iXCells Biotechnologies Launches iPSCoreâ„¢ Platform for Generating Highly Characterized iPSC-derived Human Cell Models
[iXCells Biotechnologies (BusinessWire)] iXCells Biotechnologies announced the launch of its modular iPSCoreâ„¢ platform. iPSCoreâ„¢ is a system where tools, experiences, and expertise are structured together to design, develop and build iPSC-derived cell products from ethically sourced biospecimens, and cell fractions or cells derived from healthy or patient donors.
ESC Models of Autism with Copy-Number Variations Reveal Cell-Type-Specific Translational Vulnerability
[Cell Genomics] Scientists establish a biological resource including 63 genetically modified mESC lines as genetic models of autism spectrum disorder. They performed neural differentiation using 12 representative cell lines, and their comprehensive analyses, including single-cell RNA sequencing, uncover cell-type-specific susceptible pathways.
Unraveling Mitochondrial Influence on Mammalian Pluripotency via Enforced Mitophagy
[Cell] The authors eliminated mitochondria from PSCs by enforced mitophagy and show that PSCs survive for several days in culture without mitochondria.
An Overview on Cardiac Regeneration Revolution: Exploring the Promise of Stem Cell Therapies
[Molecular Biology Reports] Scientists discuss the therapeutic potential of various stem cell types, such as mesenchymal stem cells, cardiac progenitor cells, iPSCs, and ESCs in promoting cardiac repair.
Enhancement of Hepatic Differentiation from Induced Pluripotent Stem Cells by Suppressing Epithelial-Mesenchymal Transition
[Hepatology Communications] Scientists optimized the differentiation protocol by addition of a combination of small molecules to inhibit epithelial–mesenchymal transition in iPSC-derived hepaticytes, and further characterized their function both in vitro and in vivo analyses.
ELTD1 Inhibits Differentiation of Hemogenic Endothelium Progenitors from Human Embryonic Stem Cells through the HPIP-Wnt Pathway
[Experimental & Molecular Medicine] Through dynamic gene expression profiling analysis and verification, scientists found that ELTD1 expression parallels genes related to the specification of hemogenic endothelium progenitors (HEPs) from hESCs and is highly expressed in the HEPs.
H3.3 Deposition Counteracts the Replication-Dependent Enrichment of H3.1 at Chromocenters in Embryonic Stem Cells
[Nature Communications] Scientists investigated the nuclear distribution of H3.1 and H3.3 variants, focusing on their relative enrichment at chromocenters throughout the cell cycle and in different cellular states.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
