Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells
[Stem Cells] Scientists deleted the whole genomic region of the m6A reader YTHDF2 and discovered that YTHDF2 is dispensable for the maintenance, but important for the differentiation of hESCs, especially for the differentiation towards ectoderm.
p53-Inducible lncRNA LOC644656 Causes Genotoxic Stress-Induced Stem Cell Maldifferentiation and Cancer Chemoresistance
[Nature Communications] Researchers identified the p53-induced long non-coding RNA LOC644656 as a key regulator of genotoxic stress-induced stem cell maldifferentiation in hESCs.
Shaking Culture Attenuates Circadian Rhythms in Induced Pluripotent Stem Cells during Osteogenic Differentiation through the TEAD-Fbxl3-CRY Axis
[Cell Death Discovery] Scientists investigated the effects of shaking cultures on the circadian rhythm of key clock genes in iPSC-embryoid bodies.
Stem Cell Models of Human Embryo Implantation and Trophoblast Invasion
[Current Opinion In Genetics & Development] The authors review how embryo and placenta models built from naïve stem cells can be leveraged to obtain mechanistic insights into human implantation and trophoblast invasion.
IGF2BP1 Restricts the Induction of Human Primordial Germ Cell Fate in an M6a-Dependent Manner
[Cell Stem Cell] Investigators reported that a knockout of m6A writers or overexpression of m6A erasers leads to an increased percentage of human primordial germ-like cells induced from ESCs using a 3D aggregate system.
UniXell Biotechnology Announces the First Patient Dosed with UX-DA001, an Investigational Autologous iPSC Based Cell Therapy for the Treatment of Parkinson’s Disease, in Its...
[UniXell Biotech (BioSpace)] Shanghai UniXell Biotechnology Co., Ltd. (UniXell Biotech) announced the successful first administration of its proprietary Parkinson's disease cell drug UX-DA001 in China.
Applied StemCell Launches Two New Hypoimmunogenic hiPSC Products to Accelerate Allogeneic Cell Therapy Development
[Applied StemCell] Applied StemCell announced the launch of their first hypoimmunogenic hiPSC products which are designed to empower researchers developing next-generation allogeneic cell therapies.
Cellino’s iPSC Manufacturing Technology Receives FDA Advanced Manufacturing Technology (AMT) Designation
[Cellino (BioSpace)] Cellino announced that its optical biomanufacturing technology for generating iPSCs has received the FDA’s AMT designation from the Center for Biologics Evaluation and Research.
Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells
[Stem Cell Reports] Scientists investigated the immediate consequences of inducing aneuploidy in hPSCs and the long-term fate of mosaic aneuploid and diploid populations.
DEK-Nucleosome Structure Shows DEK Modulates H3K27me3 and Stem Cell Fate
[Nature Structural & Molecular Biology] Investigators revealed that DEK safeguards mESCs from acquiring primitive endoderm fates by modulating the repressive histone mark H3K27me3.
Small Molecule and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells
[Development] Scientists characterized three small molecule and two cell contact-inducible systems for gene expression in and differentiation of mESCs.
Deciphering Signaling Mechanisms and Developmental Dynamics in Extraembryonic Mesoderm Specification from hESCs
[Nature Communications] Investigators reported that the modulation of BMP, WNT, and Nodal signaling pathways can rapidly and efficiently induce the differentiation of both naive and primed hESCs into extraembryonic mesoderm-like cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
