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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Nuclear Localization and Upregulation of BAI1 in Alveolar Macrophages during LPS-Induced Acute Lung Injury
Investigators investigated brain-specific angiogenesis inhibitor-1 (BAI1) expression in alveolar macrophages and changes in BAI1 expression levels in an acute lung injury (ALI) model. A...
FibroBiologics Confirms Ability to Manufacture CybroCellâ„¢ for Degenerative Disc Disease and Cartilage Repair Programs from Existing CYWC628 Master Cell Bank
[FibroBiologics, Inc. (Globe Newswire)] FibroBiologics, Inc. announced an advancement in its cartilage repair program. CYWC628 spheroids used in its wound healing program can be directly differentiated into chondrocytes.
A Spheroid Model That Recapitulates the Protective Role of the Lymph Node Microenvironment and Serves As a Platform for Drug Testing in Chronic Lymphocytic...
[HemaSphere] Scientists developed a novel in vitro 3D lymph node-like spheroid model of the leukemic microenvironment by culturing human chronic lymphocytic leukemia cells with fibroblastic reticular cells
The PAX3-FOXO1 Fusion Gene Reduces Cell-ECM Interactions and TGFβ Signaling in Rhabdomyosarcoma
[Journal of Cell Biology] Scientists identified downregulation of genes related to cell–ECM interactions and TGFβ signaling in FPRMS, and confirmed that TGFβ signaling enhances cell–ECM interactions in FNRMS.
LATS1/2–Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts
[Cancer Science] Researchers demonstrated that the Hippo pathway-associated kinases, LATS1/2, in cancer cells are essential for collective force generation and fibroblast activation via ECM-mediated cell–cell interactions.
Decoding the Immune Microenvironment of Secondary Chronic Myelomonocytic Leukemia Due to DLBCL With CD19 CAR-T Failure by Single-Cell RNA-Seq
[Chinese Medical Journal] Researchers characterized the immune microenvironment of a newly identified secondary tumor post-CAR-T therapy, to clarify its pathogenesis and potential therapeutic targets.
The PAX3-FOXO1 Fusion Gene Reduces Cell-ECM Interactions and TGFβ Signaling in Rhabdomyosarcoma
[Journal of Cell Biology] Scientists identified downregulation of genes related to cell–ECM interactions and TGFβ signaling in FPRMS, and confirmed that TGFβ signaling enhances cell–ECM interactions in FNRMS.
LATS1/2–Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts
[Cancer Science] Researchers demonstrated that the Hippo pathway-associated kinases, LATS1/2, in cancer cells are essential for collective force generation and fibroblast activation via ECM-mediated cell–cell interactions.
Non-Canonical ALK7 Pathways Promote Pancreatic Cancer Metastasis through β-catenin/MMP-Mediated Basement Membrane Breakdown and Intravasation
[Molecular Cancer] The authors identified an ALK7-driven non-canonical pathway that promotes pancreatic ductal adenocarcinoma dissemination. The ALK7–β-catenin–MMP axis facilitates metastatic invasion by upregulating MMP production, leading to ECM degradation and invadosome formation.
Adhesin Als4112 Promotes Candida Auris Skin Colonization through Interactions with Keratinocytes and Extracellular Matrix Proteins
[Nature Communications] Investigators showed that a C. auris conserved adhesin, Als4112, is required for skin colonization via keratinocyte attachment and direct interactions with host ECM proteins, especially basement membrane proteins such as laminin.
Tumor-Intrinsic Alterations and Stromal Matrix Remodeling Promote Wnt-Niche Independence during Diffuse-Type Gastric Cancer Progression
[Gut] Researchers demonstrated that tumour cell-derived ligand expression and ECM remodeling sustain Wnt signaling during diffuse-type gastric cancer progression.
CircERC1 Facilitates Chemoresistance through Inhibiting Pyroptosis and Remodeling Extracellular Matrix in Pancreatic Cancer
[Molecular Cancer] Scientists revealed a novel circERC1 as a key regulator in pancreatic ductal adenocarcinoma-secreted EVs following paclitaxel treatment, thereby inhibiting gemcitabine/Nab-paclitaxel induced pyroptosis.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
