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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Glioblastoma Shift from Bulk to Infiltrative Growth Is Guided by Plexin-B2-Mediated Microglia Alignment in Invasive Niches
[Nature Cancer] Scientists identified a critical role of plexin-B2 in tumor associated macrophages for resolving cell collision, aligning glioblastoma cells, and restructuring the ECM
The Stiffness of Extracellular Matrix (ECM) in Regulating Cellular Metabolism
[American Journal of Physiology - Cell Physiology] Recent studies have highlighted the intricate relationship between ECM stiffness and cellular metabolism, influencing key pathways such as glucose, lipid and amino acid metabolism. This review explores how ECM stiffness modulates these metabolic processes, emphasizing the underlying mechano-transduction mechanisms.
SOLFEGE Project Aims to Map the Hidden Language of Cell Communication in Cancer
[Institute for Bioengineering of Catalonia (EurekAlert)] The project, funded by the Human Frontier Science Program aims to explore how different cell types coordinate with each other through soluble factors in the tumour microenvironment.
Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development
[Advanced Healthcare Materials] Scientists employed synthetic, matrix metalloproteinase-degradable polyethylene glycol-based hydrogels to define the effect of mechanical and biochemical cues on cardioid development.
3D Hydrogel Platform with Macromolecular Actuators for Precisely Controlled Mechanical Forces on Cancer Cell Migration
[Nature Communications] Researchers investigated how different force parameters—magnitude, frequency, and duration—affect the migration and invasion of ovarian cancer cell spheroids, focusing on the integrins αvβ3 and αvβ6.
Dynamic Regulation of Integrin β1 Phosphorylation Supports Invasion of Breast Cancer Cells
[Nature Cell Biology] Using proteomics approaches, researchers uncovered Cofilin as a component of the phosphorylated integrin-Dok1 complex and linked this axis to effective invadopodia formation, a process supporting breast cancer invasion.
Soft Matrix Promotes Immunosuppression in Tumor-Resident Immune Cells via COX-FGF2 Signaling
[Nature Communications] Scientists find, in primary patient-derived explant cultures containing resident TILs, that low compression promotes a change in the original identity of breast cancer cells from luminal to a more mesenchymal and undifferentiated state.
MMA-Induced LOXL2+ PSCs Promote Linear ECM Alignment in the Aging Pancreas Leading to Pancreatic Cancer Progression
[Cell Death & Disease] Investigators found that increased linear ECM alignment in normal pancreatic tissues from aged pancreatic ductal adenocarcinoma (PDAC) patients is associated with PDAC progression and worse outcomes.
NOXA Exacerbates Endoplasmic-Reticulum-Stress-Induced Intervertebral Disc Degeneration by Activating Apoptosis and ECM Degradation
[Cell Death Discovery] The authors showed that endoplasmic reticulum stress (ERS) induced and activated the PERK pathway during intervertebral disc degeneration development. Mechanically, ERS induces nucleus pulposus cells apoptosis and ECM degradation by upregulating PERK expression and activating NOXA expression.
Cellular Crosstalk Mediated by Meteorin-Like Regulating Hepatic Stellate Cell Activation during Hepatic Fibrosis
[Cell Death & Disease] Researchers found that hepatic Meteorin-like mRNA transcripts and protein expression are significantly downregulated in patients and mouse models of hepatic fibrosis.
Matrix Metalloproteinase-10 Promotes Kidney Fibrosis by Transactivating β-catenin Signaling
[Cell Death Discovery] Researchers showed that matrix metalloproteinase-10 promotes kidney fibrosis by trans-activating β-catenin via the epidermal growth factor receptor signaling.
Dual Ribosome Profiling Reveals Metabolic Limitations of Cancer and Stromal Cells in the Tumor Microenvironment
[Nature Communications] Dual Ribosome Profiling revealed that cancer-fibroblast interactions trigger an inflammatory program that reduces amino acid shortages during glucose starvation.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
