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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Decoding the Impact of MMP1+ Malignant Subsets on Tumor-Immune Interactions: Insights from Single-Cell and Spatial Transcriptomics
[Cell Death Discovery] Investigators utilized large-scale single-cell RNA sequencing and spatial transcriptomics to investigate matrix metalloproteinase 1 (MMP1) expression, its cellular localization, and its impact on tumor progression and immune modulation.
Strain-Stiffening Universality in Composite Hydrogels and Soft Tissues
[Nature Physics] Scientists characterized the nonlinear elasticity of composite hydrogels and soft tissues in isolation from these plastic effects, and show that their nonlinear elastic strain stiffening is driven by the stretching of the underlying biopolymer matrix.
Decoding Collagen’S Thermally Induced Unfolding and Refolding Pathways
[Proceedings of The National Academy of Sciences of The United States of America] Scientists used atomic force microscopy imaging to investigate the thermal response of collagen type IV, a key component of basement membranes.
Extracellular Matrix Stiffness in Endometrial Cancer: Driving Progression and Modulating Treatment Sensitivity via the ROCK1/YAP1 Axis
[Cell Death & Disease] Researchers demonstrated that ECM stiffness is significantly higher in endometrial cancer tissues compared to normal endometrium, correlating with elevated expression of ROCK1, a mechanosensitive kinase.
Engineered Silk Matrix As a Substitute for Acellular Dermal Matrix in Breast Reconstruction Surgery
[International Journal of Biological Macromolecules] The authors introduced a novel engineered silk matrix as an advanced solution for soft tissue regeneration, specifically in breast reconstruction surgery.
Lysyl Oxidase Mediates Regeneration of Chondrocytes and Extracellular Matrix in the Construction of Tissue-Engineered Cartilage In Vitro
[Scientific Reports] Investigators intervened in cartilage regeneration in vitro using an activator and inhibitor of lysyl oxidase (LOX), thereby evaluating the quality and mechanical properties of tissue-engineered cartilage and further investigating the role of LOX in cartilage regeneration in vitro.
Estrogen Attenuates Stiffness-Driven Fibrotic Signaling via Transcriptional Regulation
[Biophysical Journal] Scientists developed an integrative mechanobiological model to investigate how estrogen modulates stiffness-mediated fibrotic progression. The model reveals that ECM stiffness activates fibroblasts through two key pathways.
Organ Fibrosis – Beyond Collagen I Expression Fibroblast Phenotype and Basement Membrane Proteins
[American Journal of Physiology-Cell Physiology] The authors discuss a summary of some recent advances in uncovering critical fibroblast activation states, ECM organization, and composition of fibrotic ECM, including basement membrane components.
Estrogenic Control of Matrix Metalloproteinases: A Perspective on Breast Tumor Invasion and Metastasis
[Molecular Biology Reports] Investigators provide a round-up of the prominent literature that presents estrogenic control of matrix metalloproteinases, which in turn implies its influence on the tumor microenvironment and metastasis.
ECM Therapeutics Receives FDA IDE Approval for US Feasibility Study of ECMT-100 in Treatment of Anorectal Fistulas
[ECM Therapeutics, Inc.] ECM Therapeutics, Inc. received USD FDA approval of its Investigational Device Exemption application for ECMT-100, a hydrogel derived from complete ECM for the treatment of anorectal fistulas.
Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease
[Nature Communications] Researchers showed that human-derived brain organoids with LIS1 mutation exhibit increased stiffness compared to controls at multiple developmental stages. This stiffening correlates with abnormal ECM expression and organization.
Reinforced Granular Hydrogels Scaffolds with Tunable Physicochemical Properties for Advanced Skin Tissue Engineering
[Advanced Science] Investigators introduced a strategy for synthesizing vinyl-functionalized hydrogel microparticles using a binary macromonomer system comprising hyperbranched polyethylene glycol and thiolated gelatin within microfluidic droplet templates.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
