Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
Lavrentieva, A., Fleischhammer, T., Enders, A., Pirmahboub, H., Bahnemann, J., & Pepelanova, I. (n.d.). Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer. Macromolecular Bioscience, n/a(n/a), 2000107. https://doi.org/10.1002/mabi.202000107 Cite
Full Article

Continue reading “Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer”

Bookmark

No account yet? Register

0
Share

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial

Continue reading “Huge Open-Access Journal Deal Inked by University of California and Springer Nature”

Bookmark

No account yet? Register

0
Share

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe]
Cirovic, B., Bree, L. C. J. de, Groh, L., Blok, B. A., Chan, J., Velden, W. J. F. M. van der, Bremmers, M. E. J., Crevel, R. van, Händler, K., Picelli, S., Schulte-Schrepping, J., Klee, K., Oosting, M., Koeken, V. A. C. M., Ingen, J. van, Li, Y., Benn, C. S., Schultze, J. L., Joosten, L. A. B., … Schlitzer, A. (2020). BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. Cell Host & Microbe, 0(0). https://doi.org/10.1016/j.chom.2020.05.014 Cite
Full ArticleGraphical Abstract

Continue reading “BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment”

Bookmark

No account yet? Register

0
Share

Partner Therapeutics Announces Initiation of Clinical Trial Evaluating Leukine® in T Cell Replete HLA-mismatched Haploidentical Stem Cell Transplant

Partner Therapeutics announced the enrollment of the first patient dosed in a Phase II investigator-initiated study evaluating the efficacy and safety of Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide.
[Partner Therapeutics, Inc.]
Press Release

Continue reading “Partner Therapeutics Announces Initiation of Clinical Trial Evaluating Leukine® in T Cell Replete HLA-mismatched Haploidentical Stem Cell Transplant”

Bookmark

No account yet? Register

0
Share

Curis Announces FDA Clearance of IND Application for CI-8993, the First-In-Class Monoclonal Anti-VISTA Antibody

Curis, Inc. announced that the FDA has cleared its Investigational New Drug (IND) application for CI-8993, the first-in-class monoclonal anti-VISTA antibody.
[Curis, Inc.]
Press Release

Continue reading “Curis Announces FDA Clearance of IND Application for CI-8993, the First-In-Class Monoclonal Anti-VISTA Antibody”

Bookmark

No account yet? Register

0
Share

Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease

Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.
[Blood]
Abstract

Continue reading “Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease”

Bookmark

No account yet? Register

0
Share

MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]
Full ArticleGraphical Abstract

Continue reading “MicroRNAs in Hematopoietic Stem Cell Aging”

Bookmark

No account yet? Register

0
Share

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.
[Cancers]
Full Article

Continue reading “Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations”

Bookmark

No account yet? Register

0
Share

Clonal Hematopoiesis Is Associated with Adverse Outcomes in Multiple Myeloma Patients Undergoing Transplant

Targeted sequencing of the stem cell product from 629 multiple myeloma patients treated by autologous stem cell transplant at the Dana-Farber Cancer Institute detected clonal hematopoiesis of indeterminate potential in 136/629 patients.
[Nature Communications]
Full Article

Continue reading “Clonal Hematopoiesis Is Associated with Adverse Outcomes in Multiple Myeloma Patients Undergoing Transplant”

Bookmark

No account yet? Register

0
Share

Nuclear Interacting SET Domain Protein 1 Inactivation Impairs GATA1-Regulated Erythroid Differentiation and Causes Erythroleukemia

Researchers showed that nuclear receptor binding SET domain protein 1 knockdown alters erythroid clonogenic growth of human CD34+ hematopoietic cells.
[Nature Communications]
Full Article

Continue reading “Nuclear Interacting SET Domain Protein 1 Inactivation Impairs GATA1-Regulated Erythroid Differentiation and Causes Erythroleukemia”

Bookmark

No account yet? Register

0
Share

Knock-Out of Hopx Disrupts Stemness and Quiescence of Hematopoietic Stem Cells in Mice

Scientists generated a mouse model with hematopoietic cell-specific knockout of Hopx (Hopx−/−). In young Hopx−/− mice, the HSCs showed decreased reconstitution ability after serial transplantation.
[Oncogene]
Abstract

Continue reading “Knock-Out of Hopx Disrupts Stemness and Quiescence of Hematopoietic Stem Cells in Mice”

Bookmark

No account yet? Register

0
Share
Share