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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Hepatic Stellate Cells: Balancing Homeostasis, Hepatoprotection and Fibrogenesis in Health, and Disease
[Nature Reviews Gastroenterology & Hepatology] Scientists review how hepatic stellate cells mediators, such as R-spondin 3, hepatocyte growth factor, and bone morphogenetic proteins, regulate critical and homeostatic liver functions in health and disease via cognate receptors in hepatocytes, Kupffer cells, and endothelial cells.
Cellular Crosstalk Mediated by Meteorin-Like Regulating Hepatic Stellate Cell Activation during Hepatic Fibrosis
[Cell Death & Disease] Researchers found that hepatic Meteorin-like mRNA transcripts and protein expression are significantly downregulated in patients and mouse models of hepatic fibrosis.
PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma
[Advanced Science] Investigators reported that phosphatidylinositol 4-phosphate 5-kinase 1 alpha (PIP5K1A) promotes HCC tumorigenesis and predicts poor prognosis in HCC patients.
HBO1 Functions As an Epigenetic Barrier to Hepatocyte Plasticity and Reprogramming during Liver Injury
[Cell Stem Cell] Scientists utilized single-cell chromatin landscape profiling and in vivo genetic screens to characterize the epigenetic basis of hepatocyte-to-biliary epithelial cell conversion.
TATA-Box Binding Protein Associated Factor 2 (TAF2) in Hepatocyte Survival and Tumorigenesis
[Hepatology] The authors explored the role of TATA-box binding protein associated factor 2 (TAF2) in HCC regulation using a hepatocyte-specific conditional knockout mouse, TAF2 knockdown and overexpressing human HCC cells, and TAF2 overexpression in mouse liver by hydrodynamic approach.
Suppressing MASH Fibrotic Progression by Blocking Succinate-GPR91 Signaling in Hepatic Stellate Cells
[Hepatology] Administration of succinate significantly exacerbated fibrosis in choline-deficient amino acid-defined-fed wild type mice, as evidenced by increased collagen deposition and hydroxyproline levels along with an increased GPR91 expression in activated HSCs.
GSK to Acquire Efimosfermin, a Phase III-Ready Potential Best-in-Class Specialty Medicine to Treat, and Prevent Progression of Steatotic Liver Disease (SLD)
[GSK Plc.] GSK plc and Boston Pharmaceuticals announced that they have entered into an agreement under which GSK will acquire Boston Pharmaceuticals’ lead asset, efimosfermin alfa.
ECM1 Protects against Liver Steatosis through PCBP1-Mediated Iron Homeostasis
[Hepatology] Hepatic extracellular matrix protein 1 (ECM1) expression was evaluated and found to be significantly reduced in liver samples from patients with metabolic dysfunction-associated steatohepatitis, and in four established MASH mouse models.
GPD1L Supports Glycerol-3-Phosphate and Triacylglycerol Synthesis and Promotes Tumor Progression in Hepatocellular Carcinoma
[Hepatology] Investigators performed transcriptomic analysis on clinical HCC samples from in-house and public cohorts and detected upregulation of glycerol-3-phosphate dehydrogenase 1 like among glycerol phosphate dehydrogenase family genes in HCC.
UFMylation Safeguards Human Hepatocyte Differentiation and Liver Homeostasis by Regulating Ribosome Dissociation
[Cell Reports] Scientists systematically demonstrate the significance of UFMylation in the differentiation and maturation of hepatocytes using hESC-derived hepatocyte-like cells and liver bud organoids as experimental platforms.
Metabolic Dysfunction-Associated Steatotic Liver Disease and Pregnancy
[Journal of Clinical Investigation] Although routine screening for metabolic dysfunction–associated steatotic liver disease has not been established in pregnancy, individuals with metabolic comorbidities, such as type 2 diabetes mellitus, should be evaluated by liver imaging and liver panel.
Bile Acid Accumulation Induced by mir-122 Deficiency in Liver Parenchyma Promotes Cancer Cell Growth in Hepatocellular Carcinoma
[Molecular Therapy-Nucleic Acids] The authors discovered that elevated hepatic bile acids were associated with miR-122 downregulation during liver regeneration, steatosis, and fibrosis.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
