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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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Next-Generation CAR-T Cells Design: Leveraging Tumor Features for Enhanced Efficacy
[Molecular Cancer] The authors discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.
Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function
[Immunology] Scientists highlight the critical roles of STAT1, STAT3, STAT5 and HIF1α in regulating mucosal-Associated Invariant T (MAIT) cell effector functions.
CD2 Costimulation Strength: A Key Regulator of T Cell Function and Anti-Tumor Immunity That Is Epigenetically Regulated
[Iscience] Scientists found that CD2 expression is markedly reduced in CD4+ and CD8+ tumor-infiltrating T cells from human brain tumors.
Regulation of T Cell Exhaustion and Stemness: Molecular Mechanisms and Implications for Cancer Immunotherapy
[Cellular & Molecular Immunology] The authors summarize recent advances in understanding the molecular mechanisms controlling the exhaustion and stemness of T cells and explores the potential of rewiring these circuits to increase the efficiency of T-cell-based immunotherapy.
Bringing Natural Killer Cells to the Clinic: Opportunities Beyond Cancer
[Journal of Experimental Medicine] The biology of NK cells has been exploited in innovative cancer immunotherapies, leading to clinical advances including allogeneic NK cell infusions, chimeric antigen receptor NK cells, and NK cell engager technologies.
The “Target Tissues” As Orchestrators of Autoimmune Responses: The Paradigm of SjöGren’S Syndrome
[Clinical and Experimental Immunology] Using Sjögren's disease as a paradigm, scientists discuss the role of salivary gland epithelial cells not as innocent bystander targets of autoimmune responses, but rather as initiators and amplifiers of the inflammatory reactions.
First Patient in Arizona Treated with New Immune-Cell Therapy at HonorHealth Research Institute
[HonorHealth Research Institute (EurekAlert)] A patient with synovial sarcoma, a soft-tissue cancer that usually occurs in the large joints of the arms and legs, is the first in Arizona treated with a new immune-cell-therapy known as TECELRA at the HonorHealth Research Institute.
The Diverse Roles of Lipid Metabolism Reprogramming in Shaping the Tumor Immune Microenvironment
[Cancer Research] By discussing potential therapeutic strategies to target lipid metabolism in tumor-infiltrating lymphocytes, along with combination approaches with chemo-immunotherapy, nanomedicine, and adoptive cell transfer therapy, scientists lay the groundwork for advancing effective treatments for cancer patients.
The Chaperone GRP94 Interacts with the Proprotein Convertase Furin and Regulates TGF-Beta Maturation in Human Primary M2 Macrophages
[Cell Death Discovery] Researchers demonstrated in human primary M2 macrophages that GRP94 interacts with furin and that glucose-regulated protein 94 (GRP94) inhibition by its selective inhibitor PU-WS13 led to a decrease in furin enzymatic activity, which was associated with a decrease in TGFβ secretion.
Immune Control of Functional Memory CD8 T Cells in Normal-Appearing Vitiligo Skin
[Science Advances] By combining cellular and transcriptomic approaches, scientists showed that common CD8+ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional skin of patients with vitiligo.
Single-Cell Transcriptomic Analysis Reveals RNA-Binding Protein Dysregulation in Immune Checkpoint Inhibitor-Induced Colitis
[Journal of Leukocyte Biology] The authors highlighted the regulatory role of RNA-binding proteins in immune checkpoint inhibitor-induced colitis and identified cell-type-specific alterations that may drive disease progression.
Imbalance of Stem-Like and Effector T Cell States in Children with Early Type 1 Diabetes across Conventional and Regulatory Subsets
[Nature Communications] Scientists observed that children with diabetes show diminished effector and cytotoxic programs and enhanced stemness-associated gene signature across diverse T cell subsets, especially at diagnosis.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
