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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Advances in mRNA-Lipid Nanoparticle Engineering for Immune Cell Targeting and Immune Modulation
[Small Methods] The authors highlight progress in engineering mRNA-lipid nanoparticles for targeted immune cell delivery, strategies for immune cell-specific modulation, and applications across immune-related pathologies.
NRF2 Immunobiology in Cancer: Implications for Immunotherapy and Therapeutic Targeting
[Oncogene] Mechanistic insights from genetically engineered mouse models, in vitro studies, and clinical trial samples demonstrate how nuclear factor erythroid 2-related factor 2 (NRF2) activity supports cell resiliency, diminishes cytotoxic immune responses, and promotes metabolic reprogramming.
TUG1 Targeting Enhances Anticancer Immunity Thereby Facilitating Lenvatinib Efficacy in Hepatocellular Carcinoma
[Genes & Immunity] Scientists reported that TUG1 is upregulated in hepatocellular carcinoma, particularly in advanced-stage disease, and PD-L1 expression positively correlates with TUG1 levels.
Promoting the Therapeutic Potential of Interleukin-7 (IL-7) by Expression in Viral Vectors
[Cancer Gene Therapy] To effectively harness IL-7’s antitumor potential, both oncolytic and non-lytic viruses have been engineered to express IL-7, either alone or in combination with other immunomodulators, such as IL-12, IL-15, B7-1, or CCL19.
Large B-Cell Lymphoma Imprints a Dysfunctional Immune Phenotype That Persists Years after Treatment
[Blood] Comprehensive characterization of immune changes from fresh, peripheral whole blood revealed a functionally relevant increase of myeloid-derived suppressor cells, reduced naïve T cells, and an increase of activated and terminally differentiated T cells before treatment, which aggravated after therapy.
Augmented CD47 Expression Impairs Alloreactive T-Cell Clearance after Allo-HCT
[Blood] Researchers identified the “do not eat me” signal CD47 as a promising target for therapeutic interventions aimed at eradicating alloreactive T cells subsequent to allogeneic hematopoietic cell transplantation.
mTOR Activity and Metabolic Reprogramming of CD8+ T Cells Is Impaired Under Hypoxia and Within the Multiple Myeloma Bone Marrow
[Blood Advances] Investigators assessed CD8+ T cell responses to stimulation under hypoxia, which identified that activation, proliferation, and interferon-gamma secretion were profoundly suppressed, whilst cytotoxicity and tumour necrosis factor-alpha expression were unaffected.
SPP1+ Neutrophils Mediate Resistance to Lmmune Checkpoint Blockade in BAP1-Inactivated Tumors
[Cancer Research] The authors showed that BAP1 inactivation fosters an immunosuppressive tumor microenvironment, marked by increased infiltration of M2-like macrophages and neutrophils.
SwRI, UT San Antonio Collaborate to Advance Smart Biosensors for Improved CAR T-Cell Production
[SwRI] Southwest Research Institute (SwRI) and The University of Texas at San Antonio are advancing a smart biosensor coating to streamline the production of immunotherapies for cancer treatments. Researchers plan to use novel biosensor coatings to enable automated processes and reduce human errors and costs associated with their production.
UC Allergist Receives $300,000 Grant to Research Rare Esophageal Disease
[UC News] Dr. Simin Zhang, an allergist and research assistant professor in the Division of Rheumatology, Allergy and Immunology has been awarded a three-year, $300,000 grant from the American Academy of Allergy, Asthma & Immunology. Her research focuses on the roles of mast cells and their interactions with fibroblasts.
A Spatial Map of MAPK-Activated Immunosuppressive Myeloid Populations in Pediatric Low-Grade Glioma
[Nature Immunology] Using imaging mass cytometry, researchers spatially characterized at the single-cell level the tumor microenvironment of 120 pediatric low-grade glioma cases, considering age, molecular drivers, brain location, and tumor subtype.
Allogeneic CD19-Targeting T Cells for Treatment-Refractory Systemic Lupus Erythematosus: A Phase 1 Trial
[Nature Medicine] Scientists developed YTS109, a hypoimmune allogeneic T cell product engineered using CRISPR–Cas9 to knock out TRAC, PD1, HLA-A, HLA-B, and CIITA, with a CD19-targeting synthetic TCR and antigen receptor (STAR) precisely integrated into the TRAC locus to enable physiological, TCR-like signaling.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
