Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Immune Cells Dying from Ferroptosis: Mechanisms and Therapeutic Opportunities

December 4, 2025

[Cell Death & Disease] The authors summarize the therapeutic potential of targeting ferroptosis pathways in tumor immunity, pathogen infections, inflammation, and autoimmune diseases.

BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19–YBX1 Axis to Induce Immune Evasion in Gastric Cancer

December 4, 2025

[Cancer Immunology Research] Functional studies demonstrated that BFAR knockdown suppresses tumor growth by reducing neutrophil infiltration and immunosuppressive reprogramming to restore CD8+ T cell function.

Imfinzi Approved in the US As First and Only Perioperative Immunotherapy for Patients with Early Gastric and Gastroesophageal Cancers

November 28, 2025

[Astrazeneca] AstraZeneca’s Imfinzi in combination with standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel chemotherapy has been approved in the US for the treatment of adult patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction cancers.

DIS3 Licenses B Cells for Plasma Cell Differentiation in Humans

November 25, 2025

[Cellular & Molecular Immunology] Researchers developed an antisense oligonucleotide strategy to knock down DIS3 expression in a well-characterized model of human plasma cell differentiation.

Lysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

November 25, 2025

[Nature Communications] Scientists demonstrated that lysosomal acidity and cathepsin L activity in eosinophils are elevated in asthmatic patients and mouse models.

Single-Cell and Spatial Transcriptomics Implicate a Prognostic Function of Tertiary Lymphoid Structures in Gastric Cancer

November 25, 2025

[Nature Communications] Investigators performed integrated single-cell and spatial transcriptomic profiling of 30 gastric cancer specimens stratified by tertiary lymphoid structure spatial localization patterns.

Antigen-Specific B Cell Response Regulation by IL-10-Producing Tolerogenic Dendritic Cells

November 25, 2025

[Science Advances] Researchers showed that IL-10–producing tolerogenic dendritic cells regulate B cell responses through direct and indirect mechanisms.

Glycolysis Inhibition Functionally Reprograms T Follicular Helper Cells and Reverses Lupus

November 25, 2025

[Cell Reports] Scientists investigated the mechanisms by which the glycolysis inhibitor 2-deoxy-d-glucose reduces the expansion of T follicular helper cells and the associated production of autoantibodies in lupus-prone mice.

Myeloid-T Cell Proximity Is Prominent in Healthy Pregnancies with Extreme Fetal-Maternal HLA Incompatibility

November 25, 2025

[iScience] Investigators hypothesized that immune adaptations are needed at the fetal-maternal interface to maintain healthy pregnancy despite high HLA dissimilarity.

The Relationship between Galectin-1 Expression and the Efficacy of Anti-PD-1 Therapy for Non-Small Cell Lung Cancer Patients

November 25, 2025

[Scientific Reports] Researchers examined the potential of galectin-1 expression to predict the efficacy of anti-PD-1 therapy for patients with non-small cell lung cancer.

Epigenetic Modifier m⁶a Methylation: Insights into the Pathogenesis and Therapeutic Potential of Autoimmune Diseases

November 25, 2025

[Journal of Translational Medicine] The authors provide an overview of recent advances in m⁶A biology in autoimmunity and discuss their implications for diagnosis and therapeutic intervention.

Dual Targeting of PD-1/PD-L1 and Il-33/ST2 Signaling Pathways: A Promising Approach in Breast Cancer Immunotherapy

November 25, 2025

[Annals of Medicine] Investigators sysnthesize current literature on the PD-1/PD-L1 and IL-33/ST2 pathways in breast cancer progression, focusing on their mechanisms of immune suppression and tumor microenvironment modulation.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.