Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Oncolytic Viruses: Advanced Strategies in Cancer Therapy

February 6, 2026

[Signal Transduction and Targeted Therapy] The authors discuss the classification of oncolytic viruses and their multimodal mechanisms that target tumorigenesis, metastasis, disease recurrence, and therapy resistance.

Fecal Microbiota Transplantation Plus Immunotherapy in Metastatic Renal Cell Carcinoma: The Phase I PERFORM Trial

February 5, 2026

[Nature Medicine] 20 treatment-naive patients with metastatic renal cell carcinoma received encapsulated healthy donor fecal microbiota transplantation combined with ipilimumab/nivolumab, pembrolizumab/axitinib, or pembrolizumab/lenvatinib.

Innovative Biomaterials Synergize Oncolytic Virus for Elevating Tumor Immunotherapy Potency

February 5, 2026

[Advanced Materials] The authors examined the synergistic combination of biomaterials with oncolytic viruses to enhance cancer immunotherapy, emphasizing two major categories: nanomaterial-based carriers and cell-derived materials.

FAM135B Deficiency Inhibits Cytotoxic T-Cell Activity in Triple-Negative Breast Cancer by Blocking the IFI16-Dependent STING Pathway

February 5, 2026

[Cancer Immunology Research] Scientists identified family with sequence similarity 135 member B (FAM135B) as a regulator of antitumor immunity in triple negative breast cancer.

IL4/IL13 Inhibition via Dupilumab Reduces Malignant T-Cell Proliferation and Promotes Antitumor Immunity in SéZary Syndrome

February 5, 2026

[Cancer Immunology Research] Researchers investigated the potential therapeutic effect of REGN668, an monoclonal antibody that blocks the IL4/IL13 pathway by targeting the receptors’ common IL4Rα subunit.

Targeting Epigenetic Regulators to Boost T Cell Immunotherapy against Cancer

February 5, 2026

[Cell & Bioscience] The authors examine key epigenetic regulators—such as DNA methylation, mRNA methylation, and histone methylation—and their roles in shaping T cell states during infection and tumorigenesis.

The Development of Innate Lymphoid Cells

February 5, 2026

[Nature Immunology] Scientists present recent insights into the earliest steps of innate lymphoid cells specification, as well as new evidence for developmental pathways that generate two functionally distinct types of natural killer cells.

US FDA Grants to Wugen’s WU-CART-007 Breakthrough Therapy Designation for Treatment of Relapsed or Refractory T Cell Acute Lymphoblastic Leukemia / T Cell Lymphoblastic...

January 27, 2026

[Wugen, Inc.] Wugen, Inc. announced that it has received Breakthrough Therapy Designation from the US FDA for its investigational CAR-T cell therapy, Sofi-cel.

Ouro Medicines Receives US FDA Fast Track Designation for Gamgertamig in Immune Thrombocytopenia and Autoimmune Hemolytic Anemia

January 27, 2026

[Ouro Medicines,] Ouro Medicines announced that gamgertamig, the company’s BCMAxCD3 T cell engager antibody investigational candidate, has been granted US FDA Fast Track designation for development in the treatment of autoimmune hemolytic anemia and for immune thrombocytopenia.

Immunosuppressive Immune Microenvironment Landscapes in VISTA-High Gastric Cancer

January 27, 2026

[British Journal of Cancer] Researchers conducted multiplex immunohistochemistry on tumor samples from 172 patients to characterize the immune landscape of the V-domain Ig-containing suppressor of T cell activation (VISTA)-high tumor microenvironment.

A Single-Cell Atlas of Bone Marrow B Cells Reveals Defective Central B-Cell Tolerance in Immune Thrombocytopenia

January 27, 2026

[Blood] The authors investigated how central B cell tolerance mechanisms affect autoantibody production in immune thrombocytopenia.

Vδ1 T-Cell Subset Appears to Be Responsive to PD-1 Blockade Therapy and Is Associated with Survival in Melanoma

January 23, 2026

[Journal for Immunotherapy of Cancer] Researchers nvestigated the phenotype, functionality and t cell receptor repertoire of peripheral blood and tumor-infiltrating γδ T cells in patients with late-stage melanoma receiving anti-PD-1 therapy, in order to further dissect their role and potential for exploitation in cancer immunotherapy.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.