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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Lysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation
[Nature Communications] Scientists demonstrated that lysosomal acidity and cathepsin L activity in eosinophils are elevated in asthmatic patients and mouse models.
Antigen-Specific B Cell Response Regulation by IL-10-Producing Tolerogenic Dendritic Cells
[Science Advances] Researchers showed that IL-10–producing tolerogenic dendritic cells regulate B cell responses through direct and indirect mechanisms.
Glycolysis Inhibition Functionally Reprograms T Follicular Helper Cells and Reverses Lupus
[Cell Reports] Scientists investigated the mechanisms by which the glycolysis inhibitor 2-deoxy-d-glucose reduces the expansion of T follicular helper cells and the associated production of autoantibodies in lupus-prone mice.
Collaborative Research Center on Novel Cancer Therapies Extended
[University of Freiburg] The German Research Foundation announced that it would fund the existing Collaborative Research Centre (CRC) 1479 ‘Oncogene-driven immune escape (OncoEscape)‘ at the University of Freiburg for a further funding period of three and a half years.
GPR25 Promotes the Formation of Lung and Liver Tissue-Resident Memory CD8 T Cells
[Science Immunology] Using adoptive transfer, the authors found that Gpr25-deficient T cells infiltrated tissues normally after viral infection but failed to efficiently develop into tissue-resident memory CD8 T cells.
A Selective RPL15 PROTAC Degrader Enhances Anti-PD-1 Immunotherapy in a Murine Melanoma Tumor Model
[Oncogene] The authors synthesized SN-38-conjugated pomalidomide (SN38-PROTAC) and showed that SN38-PROTAC induced ubiquitin-mediated degradation of RPL15, but not topoisomerase I.
Neuroepithelial VIP-VIPR1 Interactions Differentially Control Enteric Type 1 and Type 2 Immunity
[Nature Immunology] Researchers identified neuroepithelial interactions that differentially control intestinal type 1 and type 2 immunity.
Enteric Nervous System-Derived VIP Restrains Differentiation of LGR5+ Stem Cells toward the Secretory Lineage Impeding Type 2 Immune Programs
[Nature Immunology] Scientists identified a neuroepithelial circuit in which vasoactive intestinal peptide (VIP)-positive enteric neurons act on VIPR1+ epithelial stem cells to restrain both their proliferation and secretory lineage differentiation.
Fructose Intake Driven Glycolysis-ROS-EGFR Axis Specifically Promotes the Generation and Pathogenicity of Th17 Cells
[Nature Communications] Investigators showed that increased consumption of fructose exacerbates colitis and experimental autoimmune encephalomyelitis, via pathogenic Th17 cells.
With $3M Grant, uOttawa Medical Scientist Leads Pioneering Cancer Immunotherapy Research
[University of Ottawa] Backed by a prestigious $3M Terry Fox New Frontiers Program Project Grant, Dr. Michele Ardolino and team will seek to uncover the hidden mechanisms of how the body’s immune system, nervous system, and gut microbiome interact in cancer,
Unmasking Cancer’s Silent Saboteurs: T Regulatory Cells As Therapeutic Targets in Immunotherapy
[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.
Destruction of VISTA by TRIM25 Ablation in T Cells Potentiates Cancer Immunotherapy
[Cell Research] Researchers unveiled a mechanism for V-domain Ig suppressor of T cell activation (VISTA) regulation in T cells and highlights targeting tripartite motif containing 25 (TRIM25)–VISTA as a potential strategy to enhance tumor immunotherapy.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
