Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment

October 10, 2024

[Cancer Immunology Research] The authors investigated the impact of complement factor H (FH) on Tregs within the glioma microenvironment and found that FH is an ICOS ligand.

The Extension of Mammalian Pregnancy Required Taming Inflammation: Independent Evolution of Extended Placentation in the Tammar Wallaby

October 10, 2024

[Proceedings of The National Academy of Sciences of The United States of America] By comparing gene expression changes at attachment in three marsupial species, the tammar wallaby, opossum, and fat-tailed dunnart, researchers showed that inflammatory attachment was an ancestral feature of marsupial implantation.

Transformable Gel-to-Nanovaccine Enhances Cancer Immunotherapy via Metronomic-Like Immunomodulation and Collagen-Mediated Paracortex Delivery

October 10, 2024

[Advanced Materials] By recapitulating the dynamic processes of acute infection, a bioadhesive immune niche domain was developed that facilitated the delivery of timely-activating conjugated nanovaccine (t-CNV) in a metronomic-like manner and increased the accumulation and retention of TANNylated t-CNV in lymph node.

Novel Photo-STING Agonists Delivered by Erythrocyte Efferocytosis-Mimicking Pattern to Repolarize Tumor-Associated Macrophages for Boosting Anticancer Immunotherapy

October 10, 2024

[Advanced Materials] Scientists presented a newly synthesized and screened manganese porphyrins for Mn2+ transport, referred to as photo-STING agonists, and further encapsulate them into core-shell nanoparticles named Rm@PP-GA with dual specificity for tumor tissue and tumor-associated macrophages.

Nobel Prizes Are Globally Unrepresentative — the Nomination Process Must Be Opened Up

October 10, 2024

The geography of science is changing. As a result, a big push is needed to broaden the pool of scientists eligible to nominate their...

Optimization of the Irf8 +32-Kb Enhancer Disrupts Dendritic Cell Lineage Segregation

October 9, 2024

[Nature Immunology] Researchers revealed that the Irf8 +32-kb enhancer, responsible for interferon regulatory factor 8 (IRF8) autoactivation, was naturally suboptimized with low-affinity IRF8 binding sites.

Two-Dimensional Coordination Risedronate-Manganese Nanobelts as Adjuvant for Cancer Radiotherapy and Immunotherapy

October 9, 2024

[Nature Communications] Researchers developed two-dimensional risedronate-manganese nanobelts (RMn-NBs) as an adjuvant for radiation therapy. RMn-NBs exhibited good T2 magnetic resonance imaging performance and enhanced Fenton-like catalytic activity, which induced immunogenic cell death.

Alternative Splicing of PBRM1 Mediates Resistance to PD-1 Blockade Therapy in Renal Cancer

October 9, 2024

[EMBO Journal] Investigators performed a comprehensive alternative pre-mRNA splicing analysis in cancer driver gene transcripts across fifteen cancer types and found global alterations in inclusion rates of the polybromo-associated BAF SWI/SNF chromatin remodeling complex subunit Polybromo 1 (PBRM1) exon 27 in most types of cancer tissues compared with those in normal tissues.

Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines

October 9, 2024

Investigators describe the specific contributions of iPSCs to vaccine development, summarize their diverse developmental trajectories, and discuss the obstacles to their application and potential...

Lung-Resident Alveolar Macrophages Regulate the Timing of Breast Cancer Metastasis

October 8, 2024

[Cell] Through ligand-receptor mapping and intravital imaging, it was found that alveolar macrophages express transforming growth factor-β2.

Proximity-Dependent Labeling Identifies Dendritic Cells That Drive the Tumor-Specific CD4+ T Cell Response

October 8, 2024

[Science Immunology] Using Labeling Immune Partnerships by SorTagging Intercellular Contacts–based single-cell transcriptomics, investigators identified individual dendritic cells capable of presenting antigen to CD4+ T cells in both the tumor-draining lymph node and tumor microenvironment.

MERTK Inhibition Selectively Activates a DC – T Cell Axis to Provide Anti-Leukemia Immunity

October 4, 2024

[Leukemia] Scientists probed anti-leukemia immune mechanisms and evaluated roles for TYRO3 and AXL in the leukemia microenvironment.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.