Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

A Treg-Specific Long Noncoding RNA Maintains Immune-Metabolic Homeostasis in Aging Liver

[Nature Aging] Mechanistically, Altre interacted with Yin Yang 1 to orchestrate its occupation on chromatin, thereby regulating the expression of a group of mitochondrial genes, and maintaining optimal mitochondrial function and Treg fitness in the liver of aged mice.

Distant Antimetastatic Effect of Enterotropic Colon Cancer–Derived α4β7+CD8+ T Cells

[Science Immunology] The presence of concomitant colon tumors improved control of liver lesions by anti–PD-L1 proof-of-concept immunotherapy and generated protective immune memory, whereas partial depletion of α4β7+ cells abrogated control of metastases.

Defining Blood-Induced Microglia Functions in Neurodegeneration through Multiomic Profiling

[Nature Immunology] Researchers established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity.

miR-142-3p Encapsulated in T Lymphocyte-Derived Tissue Small Extracellular Vesicles Induces Treg Function Defect and Thyrocyte Destruction in Hashimoto’s Thyroiditis

[BMC Medicine] In vitro and in vivo experiments were further performed to elucidate the function and potential mechanisms of small extracellular vesicle microRNAs that contributeed to the development of Hashimoto’s thyroiditis.

Tumour Immune Rejection Triggered by Activation of α2-Adrenergic Receptors

[Nature] The authors showed that agonists of α2-adrenergic receptors (α2-AR) had very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models, including immunecheckpoint blockade-resistant models, but not in immunodeficient models.

Growth Hormone Releasing Hormone Signaling Promotes Th17 Cell Differentiation and Autoimmune Inflammation

[Nature Communications] Growth hormone releasing hormone receptor activated the JAK-STAT3 pathway, increased the phosphorylation of STAT3, enhanced both non-pathogenic and pathogenic Th17 cell differentiation, and promoted the gene expression signatures of pathogenic Th17 cells.

IL-3 Orchestrates Ulcerative Colitis Pathogenesis by Controlling the Development and the Recruitment of Splenic Reservoir Neutrophils

[Cell Reports] Scientists reporedt that interleukin-3 (IL-3)-deficient mice were more susceptible and exhibited increased intestinal inflammation during the early stage of experimental colitis.

Neuroprotective Protein ADNP-Dependent Histone Remodeling Complex Promotes T Helper 2 Immune Cell Differentiation

[Immunity] To better understand transcriptional regulation of T helper 2 cell differentiation, researchers performed CRISPR-Cas9 screens targeting 1,131 transcription factors..They discovered that activity-dependent neuroprotector homeobox protein was indispensable for immune reactions to allergen.

Clearance of Senescent Macrophages Ameliorates Tumorigenesis in KRAS-Driven Lung Cancer

[Cancer Cell] Through single cell transcriptomics, investigators identified a population of tumor-associated macrophages that expressed a unique array of pro-tumorigenic senescence-associated secretory phenotype factors and surface proteins and were also present in normal aged lungs.

Monocyte Regulation by Gut Microbial Signals

[Trends In Microbiology] The authors discuss the newer concepts of regulation of monocyte homeostasis and function by gut microbial signals during steady state and inflammation, and highlight the therapeutic potential of microbial signal-based approaches for modulation in the context of various diseases.

Inflammation and Aging: Signaling Pathways and Intervention Therapies

[Signal Transduction And Targeted Therapy] Scientists discuss inflammaging at the molecular, cellular, organ, and disease levels, and review current aging models, the implications of cutting-edge single cell technologies, as well as anti-aging strategies.

Quell Therapeutics Signs a Collaboration, Exclusive Option and License Agreement with AstraZeneca to Develop, Manufacture and Commercialize Engineered Treg Cell Therapies for Autoimmune Diseases

[Quell Therapeutics Ltd.] Under the terms of the agreement, Quell’s proprietary toolbox of Treg cell engineering modules, including its Foxp3 Phenotype Lock, will be leveraged to develop autologous multi-modular Treg cell therapy candidates for Type 1 Diabetes and Inflammatory Bowel Disease.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.