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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
PARP11 Inhibition Inactivates Tumor-Infiltrating Regulatory T Cells and Improves the Efficacy of Immunotherapies
[Cell Reports Medicine] Scientists demonstrated that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of tumor-infiltrating regulatory T cells.
PD-1/LAG-3 Co-Signaling Profiling Uncovers CBL Ubiquitin Ligases as Key Immunotherapy Targets
[EMBO Molecular Medicine] To identify shared features associated to PD-1/LAG-3 dysfunctionality in human cancers and T cells, multiomic expression profiles were obtained for all TCGA cancers immune infiltrates.
Mucosal Signatures of Pathogenic T Cells in HLA-B*27+ Anterior Uveitis and Axial Spondyloarthritis
[JCI Insight] Investigators identified a bacterial peptide that could be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU.
Thymol Improves Ischemic Brain Injury by Inhibiting Microglia-Mediated Neuroinflammation
[Brain Research Bulletin] The authors found that thymol treatment could ameliorate post-stroke neurological impairment and reduce infarct volume by mitigating microglial activation and pro-inflammatory response.
T Cell Exhaustion and Senescence for Ovarian Cancer Immunotherapy
[Seminars In Cancer Biology] The authors summarize the phenotypic and functional features of exhaust and senescent T cells, and describes the key drivers of the two T cell dysfunctional states in the tumor microenvironment and their functional roles in ovarian cancer.
Mechanisms Underlying the Direct Programming of Mouse Embryonic Fibroblasts to Thymic Epithelial Cells by FOXN1
[Development] Researchers characterized fibroblasts transdifferentiated into thymic epithelial cell-like cells programming at the cellular and molecular level in mouse to determine how it proceeded, and have identified mechanisms that can be targeted for improving this process.
Vγ9Vδ2 T Cells Recognize Butyrophilin 2A1 and 3A1 Heteromers
[Nature Immunology] The crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engaged the side of the γδTCR, leaving the apical TCR surface bioavailable.
The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues
[Journal of Neuro-Oncology] Scientists performed a series of in vitro experiments using canine Tregs and patient-derived canine glioma cell lines to interrogate the CCL2-CCR4 signaling axis in the canine.
HHMI Invests Over $300 Million in 26 New Investigators
[HHMI] The Howard Hughes Medical Institute announced today that 26 of the nation’s leading scientists have been named HHMI Investigators. HHMI will invest more than $300 million in this newest cohort over the next seven years, enabling each Investigator to push the boundaries of science.
Sydney Puda Selected for Sixth Cohort of Veterinary Fellows to Increase Survival Rate of Male Pigs
[Pork Business] Though the reason is unknown, castrated male swine experience nearly double the mortality rate of females, explains Sydney Puda, a student at Michigan State University College of Medicine. Puda is one of 15 students who have been named as part of the sixth cohort of the Foundation for Food & Agriculture Research Veterinary Student Research Fellowship (FFAR Vet Fellows).
Single-Cell Analysis Reveals Transcriptional Dynamics in Healthy Primary Parathyroid Tissue
[Clinical Cancer Research] The authors investigated the influence of IDH status on the myeloid compartment using human glioma specimens and preclinical models.
Dihydroartemisinin Inhibits Follicular Helper T and B Cells: Implications for Systemic Lupus Erythematosus Treatment
[Archives of Pharmacal Research] In vitro experiments confirmed that dihydroartemisinin DHA inhibited Tfh cell induction and weakened its auxiliary function in B cell differentiation; furthermore, DHA directly inhibited B cell activation, differentiation, and antibody production.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
