Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Super-resolution Imaging of T Lymphocyte Activation Reveals Chromatin Decondensation and Disrupted Nuclear Envelope

[Communications Biology] Using stochastic optical reconstruction microscopy (STORM), scientists observed dramatic de-condensation of chromatin and the disruption of nuclear envelope at a nanoscale resolution upon T lymphocyte activation.

Necroptosis Stimulates Interferon-Mediated Protective Anti-tumor Immunity

[Cell Death & Disease] Scientists selectivly induced RIPK3-dependent necroptosis or apoptosis with minimal NF-κB-dependent inflammatory cytokine expression. This protective effect required CD4+/sup> T cells rather than CD8+/sup> T cells and was dependent on host type I interferon signaling.

Selective Depletion of Tumor-Infiltrating Regulatory T Cells with BAY 3375968, a Novel FC-Optimized Anti-CCR8 Antibody

[Clinical and Experimental Medicine] The chemokine receptor 8 (CCR8) was found to be predominantly expressed on Tregs within the tumor microenvironment of both humans and mice, representing a unique target for selective depletion of tumor-residing Tregs.

Bacteroides uniformis CECT 7771 Requires Adaptive Immunity to Improve Glucose Tolerance but Not to Prevent Body Weight Gain in Diet-Induced Obese Mice

[Microbiome] Investigators evaluated the effects of B. uniformis on energy homeostasis, and intestinal immunity in wild-type and Rag1-deficient mice with diet-induced obesity. They assessed whether it needed to be viable to exert its beneficial effects on obesity and to directly induce immunoregulatory effects.

Peripheral Immune Cells Contribute to the Pathogenesis of Alzheimer’s Disease

[Molecular Neurobiology] Scientists investigated the potential causal association between peripheral immune cells and Alzheimer's disease (AD) by using a two-sample Mendelian randomization analysis (TSMR). They deciphered the causal relationship between AD and 731 types of peripheral immune cell parameters from the TBNK, Treg, and B cell panels.

Microbial Metabolite Butyrate Modulates Granzyme B in Tolerogenic IL-10 Producing Th1 Cells to Regulate Intestinal Inflammation

[Gut Microbes] Investigators found that GzmbB-deficient CD4+ T cells induced more severe colitis in Rag1−/− mice than wild-type CD4+ T cells.

Immunodeviation Towards T Cell-Mediated Immune Response in the Testes of LPS-Induced Mouse Epididymo-Orchitis

[Journal of Reproductive Immunology] The data indicated that acute epididymo-orchitis could lead to long-term damage in the testes, which was characterized by CD3+ T cell-mediated immune responses.

Alterations of Thymus-Derived Tregs in Multiple Sclerosis

[Neurology-Neuroimmunology & Neuroinflammation] By combining multiple experimental approaches, researchers examined the Treg compartments in 41 patients with relapsing-remitting multiple sclerosis and 17 healthy donors.

MB2033, an Anti-PD-L1 × IL-2 Variant Fusion Protein, Demonstrates Robust Anti-Tumor Efficacy with Minimal Peripheral Toxicity

[Cancer Immunology Immunotherapy] MB2033 exhibited significantly reduced regulatory T cell activation, while inducing comparable CD8+ T cell activation to recombinant human IL-2.

Late Treatment With Autologous Expanded Regulatory T Cell Therapy after Alemtuzumab Induction Is Safe and Facilitates Immunosuppression Minimization in Living Donor Renal Transplantation

[Transplantation] Researchers established that delayed autologous Treg therapy was both feasible and safe, even 12 months after cell production. The findings presented a new treatment protocol for Treg therapy, potentially expanding its applications to other indications.

MediMab Biotherapeutics opens bespoke laboratory facilities, created by Kadans Science Partner, at Abingdon Science Park, UK

MediMab Biotherapeutics announces that it has opened a new state-of-the-art facility, developed by Kadans Science Partner, at Sovereign House, Abingdon Science Park, UK. The...

IL-6 Inhibition Prevents Costimulation Blockade-Resistant Allograft Rejection in T Cell-Depleted Recipients by Promoting Intragraft Immune Regulation in Mice

[Nature Communications] Scientists investigated why anti-thymocyte globulin (ATG) failed to prevent costimulation blockade-resistant rejection and how this barrier could be overcome. While ATG improved the balance between regulatory T cells and effector T cells in the spleen, it had no such effect within cardiac allografts.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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