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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
mAChR4 Suppresses Liver Disease via GAP-Induced Antimicrobial Immunity
[Nature] Researchers showed that chronic alcohol use in humans and mice downregulates small intestinal muscarinic acetylcholine receptor M4 (mAChR4) and reduces goblet cell-associated antigen passage (GAP) formation, disrupting antimicrobial immunity.
TCF1 and LEF1 Promote B-1a Cell Homeostasis and Regulatory Function
[Nature] Scientists showed that the transcription factors TCF1 and LEF1 are critical regulators of B-1a cells. LEF1 expression was highest in fetal and bone marrow B-1 progenitors, whereas the levels of TCF1 were higher in splenic and peritoneal B-1 cells than in B-1 progenitors.
Circadian Circuits Control Plasticity of Group 3 Innate Lymphoid Cells by Sustaining Epigenetic Configuration of RORγT
[Nature Immunology] Investigators showed that the circadian proteins REV-ERBα and REV-ERBβ maintain group 3 innate lymphoid cell (ILC3) identity.
A STUB1-CHIC2 Complex Inhibits CD8+ T Cells to Restrain Tumor Immunity
[Nature Immunology] Scientists assessed 899 genes in CD8+ T cells responding to murine melanoma and identified the E3 ubiquitin ligase STUB1 as a new negative regulator of anti-tumor CD8sup>+ T cell function.
CAR Treg Cells Mediate Linked Suppression and Infectious Tolerance in Islet Transplantation in Mice
[Science Translational Medicine] Using a model of human leukocyte antigen (HLA)-A2+ islet transplantation into immunodeficient nonobese diabetic mice, the authors investigated whether A2-CAR Treg cells could control hyperglycemia induced by diabetogenic BDC2.5 effector T cells.
Regulatory T Cell Therapy Promotes TGF-β and IL-6-Dependent Pro-Inflammatory Th17 Cell Generation by Reducing IL-2
[Nature Communications] Researchers showed that adoptive regulatory T cell therapy increases IL-6 and TGF-β-dependent pathogenic Th17 cell differentiation in murine models of inflammatory bowel disease and experimental autoimmune encephalomyelitis.
USP30 Inhibition Augments Mitophagy to Prevent T Cell Exhaustion
[Science Advances] Scientists identified ubiquitin-specific protease 30 (USP30), a mitochondrial deubiquitinase that inhibits mitophagy, as a key factor up-regulated in exhausted CD8+ T cells.
Itaconate Derivative 4-OI Inhibits M1 Macrophage Polarization and Restores Its Impaired Function in Immune Thrombocytopenia through Metabolic Reprogramming
[Chinese Medical Journal] Investigators evaluated the immunoregulatory effects of an itaconate derivative on macrophages in patients with immune thrombocytopenia.
Acesulfame Potassium Alleviates Food Allergy via Mast Cell Stabilization and MAPK-Mediated Immune Regulation
[Journal of Agricultural and Food Chemistry] Researchers investigated the therapeutic potential of acesulfame potassium using both an ovalbumin-induced murine food allergy model and IgE/BSA-activated RBL-2H3 mast cells.
Decoding the Role of Gut Mycobiota in Immune Regulation and Disease
[Virulence] The authors deepen the understanding of fungal contributions to immune homoeostasis and modulating the mycobiome in the context of health and disease.
Trethera Awarded $3 Million NIH Grant to Advance First-In-Class Drug, TRE-515, for the Treatment of Lupus
[Trethera Corporation] Trethera Corporation announced that it has been awarded a $3 million Small Business Innovation Research grant from the National Institute of Health. The award evaluates Trethera’s lead candidate, TRE-515, for the treatment of systemic lupus erythematosus.
Notch2-Expressing CD4+ T Cells Attain Immunoregulatory Functions during Autoimmune Inflammation
[Cellular & Molecular Immunology] Researchers identified CD4+Notch2+Foxp3lo T cells in the spinal cords of mice with experimental autoimmune encephalomyelitis, dextran sodium sulfate−induced colitis model mice, and patients with ulcerative colitis as immune regulatory cells.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
