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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
COVID-19 Vaccine Type Controls Stromal Reprogramming in Draining Lymph Nodes
[Science Immunology] Investigators immunized mice with clinically approved gene- and protein-based COVID-19 vaccines targeting viral spike protein and analyzed the draining lymph node stroma using multimodal bioimaging, single-cell transcriptomics, and functional studies.
Survival and Transmission Fitness of SARS-CoV-2 Over the Time-of-Flight in an Aerosolization Chamber
[NPJ Viruses] Using a novel, self-contained containment level 3 chamber, researchers aerosolized the SARS-CoV-2 virus in different environmental conditions, then collected droplets on nasal tissue, cell lines, or different materials to measure the transmission of infectious SARS-CoV-2.
A Finger-Actuated Microfluidic System for Point-of-Care Detection of SARS-CoV-2 and Influenza a
[Analytical Chemistry] Scientists developed a finger-actuated visual microfluidic chip with a colorimetric detection system based on reverse transcriptase loop-mediated isothermal amplification to enable efficient and cost-effective detection of SARS-CoV-2 and influenza A.
TIPE2 Suppresses Ferroptosis and Pro-Inflammatory Polarization in Macrophages Triggered by SARS-CoV-2 Spike Protein
[Scientific Reports] Researchers suggested that tumor necrosis factor-α-induced protein 8-like protein 2 (TIPE2) mediates critical immunomodulatory effects during the progression of SARS-CoV-2 infection, positioning it as a promising therapeutic target for mitigating pathological inflammatory responses in COVID-19 patients gravely affected.
Design, Synthesis, and SARS-CoV‑2 Main Protease Inhibitory Activities of 2-Arylthiomethyl-6-Bromoindole Derivatives
[Molecular Diversity] A series of novel 2-arylsulfanylmethyl-6-bromoindole derivatives were designed as 2019-nCoV main protease inhibitors.
EBV Induces CNS Homing of B Cells Attracting Inflammatory T Cells
[Nature] Scientists demonstrated that Epstein–Barr virus (EBV) expands oligoclonal T-bet+CXCR3+ B cells that home to the central nervous sytem in humanized mice. Effector memory CD8+ T cells and CD4+ TH1 cells as well as CD4+ TH17 cells co-migrate to the brain of EBV-infected humanized mice.
Dengue Virus Susceptibility in Aedes aegypti Linked to Natural Cytochrome P450 Promoter Variants
[Nature Communications] Researchers identified a cytochrome P450-encoding gene whose genetic variants drive differences in dengue virus susceptibility in a natural Ae. aegypti population.
Heterogeneity Across Mammalian- and Avian-Origin a(H1N1) Influenza Viruses Influences Viral Infectivity Following Incubation with Host Bacteria from the Human Respiratory Tract
[Microbiology Spectrum] The authors highlighted that both human and avian influenza A viruses (IAV) can bind to bacterial surface components from different host sites, resulting in differential functional interactions early after binding, suggesting the need to study IAV-bacteria interactions at the host range interface.
Thiazole Substitution of a Labile Amide Bond-a New Option Toward Antiplasmodial Pantothenamide-Mimics
[Antimicrobial Agents and Chemotherapy] Scientists found that thiazole substitution of the labile amide bond represents a promising avenue for developing antimalarial pantothenamide-mimics.
Pathogenic Bacteria Enriched in the Oral Microbiota Might Be Associated with Recurrent Pulmonary Infections in Elderly Individuals
[Aging Clinical and Experimental Research] Researchers explored the associations between oral and gut microbiota and pulmonary infections. Oral and gut microbiota diversity showed significant differences between patients with recurrent pneumonia and common pneumonia-infected patients.
PEDV Infection Downregulates Goblet Cell Differentiation through Activating the Notch Pathway
[Veterinary Research] Porcine epidemic diarrhoea virus (PEDV) infection reduced the number of goblet cells and impairs the intestinal barrier integrity in newborn piglets.
Innovative Adjuvant Strategies for Next-Generation Pertussis Vaccines
[Human Vaccines & Immunotherapeutics] The authors summarize the currently approved pertussis vaccines, focusing on the types of antigens and adjuvants used, and discuss the mechanisms of novel adjuvants.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
