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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Rebalancing Viral and Immune Damage Versus Repair Prevents Death from Lethal Influenza Infection
[Science] The authors clarified why anti-inflammatory therapies other than high-dose steroids have had limited impact on the course of advanced pulmonary viral infections.
Interferon-Mediated NK Cell Activation Increases Cytolytic Activity against T Follicular Helper Cells and Limits Antibody Response to SARS-CoV-2
[Nature Immunology] Scientists found that, in ancestral severe acute respiratory syndrome coronavirus 2 infection, individuals with the broadest neutralization profile had fewer NK cells that expressed inhibitory and immaturity markers.
High Expression of Interleukin-18 Receptor Alpha Correlates with Severe Respiratory Viral Disease and Defines T Cells with Reduced Cytotoxic Signatures
[Nature Communications] Researchers identified the gene encoding IL-18Rα chain, as being highly expressed in life-threatening influenza, COVID-19, RSV and multisystem inflammatory syndrome in children.
Evasion of CARD8 Activation during HIV-1 Assembly
[Science Advances] Scientists reported that coordination of HIV-1 assembly by the viral polyprotein Gag suppresses inappropriately timed protease (PR) activity to evade the PR activity sensor, caspase recruitment domain-containing protein 8 (CARD8).
Non-Apoptotic Caspase-8 Is Critical for Orchestrating Exaggerated Inflammation during Severe SARS-CoV-2 Infection
[Nature Communications] Using gene-targeted murine COVID-19 models, scientists found that caspase-8 is critical for cytokine release and inflammation. Loss of caspase-8 reduces disease severity and viral load in mice, and this occurs independently of its apoptotic function.
Epstein-Barr Virus Reprograms Autoreactive B Cells As Antigen-Presenting Cells in Systemic Lupus Erythematosus
[Science Translational Medicine] The authors developed an Epstein-Barr virus (EBV)-specific single-cell RNA-sequencing platform and used it to demonstrate that EBV infection reprograms autoreactive antinuclear antigen B cells to drive autoimmunity in systemic lupus erythematosus.
Engineered Virus-Hunter Vaccine Overcomes HBV Immune Tolerance
[Gut] Researchers developed a ‘virus-hunter vaccine’ that hijacks hepatitis B virus (HBV) antigens as endogenous immunogens, reprogramming dendritic cells to prime anti-HBV immunity, ultimately achieving a durable functional cure beyond current therapeutic limitations.
AIM2 Drives Inflammatory Cell Death and Monkeypox Pathogenesis
[Cellular & Molecular Immunology] Using CRISPR-knockout cytosolic innate immune sensor screening, scientists identified absent in melanoma 2 (AIM2) as the sensor for monkeypox virus within the inflammasome, a trigger for inflammatory cell death.
COVID-19-Associated Autoimmune and Inflammatory Diseases: Molecular Mechanisms and the Role of IVIG Therapy
[Clinical Reviews in Allergy & Immunology] The authors synthesize the current clinical and experimental evidence linking COVID-19 to autoimmune and inflammatory sequelae.
Disruption of Influenza A Virus Transmission in Gene-Edited Pigs
[Emerging Microbes & Infections] Researchers evaluated influenza A virus transmission from principal-infected TMPRSS2 knockout (KO) pigs to sentinel TMPRSS2 KO and wild-type pigs.
Human Antibody Targeting of Coronavirus Spike S2 Subunit Is Associated with Protection Mediated by Fc Effector Functions
[Journal of Virology] Researchers described a convalescent human monoclonal antibody that targets the S2 subunit of the coronavirus spike protein, with broad betacoronaviruses binding and sarbecovirus neutralization.
Targeting Cancer and SARS-CoV-2: Phytochemical, Biological and Molecular Dynamic Investigations of Sargassum Aquifolium, and Galaxaura Rugosa
[Scientific Reports] Among the various extracts, the pet. ether extract of S. aquifolium exhibited the highest antioxidant activity, whereas that of G. rugosa demonstrated potent antiviral activity against SARS-CoV-2.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
