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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Pre-Existing and Early Cellular Immune Factors Correlate with Functionally Complete Protection against Primary Controlled Human SARS-CoV-2 Infection
[Nature Communications] Scientists analyzed pre- and early post-exposure immune factors associated with resisting SARS-CoV-2 infection after human challenge in seronegative individuals, using multiplex protein, cytometric and RNA sequencing approaches in the nasopharynx and circulation.
Influenza Vaccines Promote Humoral and Cellular Immune Responses: A Randomized, Double-Blind, Phase 3 Trial
[Nature Communications] Researchers reported findings from a randomized, double-blind, active-controlled Phase III clinical trial that includes 334 healthy adults aged 18–64 years and evaluates the humoral and cellular antiviral immune responses induced by two inactivated quadrivalent influenza vaccines.
CD44 Cross-Linking Promotes Plasmodium Falciparum Invasion
[Nature Communications] The authors identified an anti-CD44 monoclonal antibody, BRIC 222, that significantly promotes P. falciparum invasion through CD44 cross-linking.
Nef Stabilizes Actin to Prevent HIV-1 Sensing by RIG-I-Like Receptors
[Nature Communications] Investigators showed that the HIV-1 accessory protein Nef prevents R12C-mediated RIG-I-like receptor priming, thereby suppressing viral sensing.
Maternal Diet Shapes the Development and Identity of Tissue-Resident Macrophages
[Trends in Immunology] The authors summarize how specific maternal diets program distinct tissue-resident macrophage (TRMs) subsets and how programmed TRMs link maternal nutritional statuses to disease susceptibility.
Single-Cell Multi-Omic Landscape Reveals Anatomical-Specific Immune Features in Adult and Pediatric Sepsis
[Nature Immunology] Researchers applied multi-omic profiling to analyze peripheral blood mononuclear cells and plasma from 281 adult and pediatric individuals with sepsis and controls.
Macrophage MR1 Antigen Presentation Promotes MAIT Cell Immunity and Lung Microbiota Modulation
[Science] Depletion of MHC class I-related protein 1 (MR1) in macrophages, dendritic cells, and monocytes changed the composition of the microbiota and impaired mucosal associated invariant T (MAIT) cell responses against bacterial infection.
ARCN1 Suppresses Innate Immune Responses against Respiratory Syncytial Virus by Promoting STUB1-Mediated IKKε Degradation
[PLoS Pathogens] Researchers demonstrated that archain 1 (ARCN1) suppresses the anti-Respiratory syncytial virus innate immune response by promoting E3 ubiquitin ligase STUB1-mediated K48-linked polyubiquitination and subsequent proteasomal degradation of IKKε.
Rroid2 Regulates Effector-to-Memory CD8+ T Cell Differentiation during Infection In Vivo
[Proceedings of the National Academy of Sciences of the United States of America] The authors performed deep RNA-seq to map the lncRNA expression landscape of CD8+ T cell subsets during infection and generated lncRNA knockout mouse models to evaluate the in vivo relevance of six lncRNAs.
Interferon-Mediated NK Cell Activation Increases Cytolytic Activity against T Follicular Helper Cells and Limits Antibody Response to SARS-CoV-2
[Nature Immunology] Researchers found that, in ancestral severe acute respiratory syndrome coronavirus 2 infection, individuals with the broadest neutralization profile had fewer NK cells that expressed inhibitory and immaturity markers, whereas NK cells from narrow neutralizers were highly activated and expressed interferon-stimulated genes.
CD8+ T Cell Stemness Precedes Post-Intervention Control of HIV Viremia
[Nature] Scientists mapped and functionally profiled CD8+ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in broadly neutralizing anti-HIV-1 antibody recipients.
Orphan Broadly RBD-Binding Antibodies Annotate Three Remaining Conserved RBD Epitopes along SARS-CoV-2 Evolution
[Nature Communications] Using a heterogeneous double-bait single B-cell sorting strategy, investigators identified a subset of antibodies with broad-spectrum receptor-binding domain (RBD) binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
