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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
CD4+ T Cells License Kupffer Cells to Reverse CD8+ T Cell Dysfunction Induced by Hepatocellular Priming
[Nature Immunology] Scientists generated hepatitis B virus-specific CD4+ T cell receptor transgenic mice to show that CD4+ effector T cells can prevent and reverse the CD8+ T cell dysfunction induced by hepatocellular priming.
The GATE Glycoprotein Complex Enhances Human Cytomegalovirus Entry in Endothelial Cells
[Nature Microbiology] Researchers identified a distinct glycoprotein H complex that is abundant on human cytomegalovirus virions and enhances infection of endothelial cells.
Rab27a Regulates the Transport of Influenza Virus Membrane Proteins to the Plasma Membrane
[Nature Communications] siRNA screening identified Rab27a as a critical host factor regulating the transport of influenza A virus membrane proteins to the cell surface.
Akt Isoform Specificity Drives Intrinsic Immune Regulation During HSV-1 Infection
[Proceedings of the National Academy of Sciences of the United States of America] Researchers provided insights into how cells navigate the balance between survival and immune defense during herpes simplex virus 1 infection, offering conceptual advancements that may extend to other viral infections.
Influenza-Specific T Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial
[Journal of Infectious Diseases] Influenza strain–specific cellular responses were detectable following vaccination despite expected B-cell depletion in patients receiving active treatment for hematological malignancy.
Proximity Labelling of Internalizing Influenza A Viruses Reveals a Role for Neogenin in Virus Uptake
[PLoS Pathogens] Scientists uncovered neogenin, a member of the immunoglobulin superfamily expressed in primary human airway cultures, as a potential epsin 1 interactor and virus receptor candidate.
Identification of Low-Molecular Compounds That Inhibit Envelope Formation of Hepatitis B Virus
[Scientific Reports] Investigators identified compounds that inhibit an interaction between large hepatitis B surface and hepatitis B core proteins, which are considered to be important for HBV envelope formation.
Vesicle-Associated Membrane Protein 5 Is an Intrinsic Defense Factor for Embryonic Stem Cells Against Coronaviruses
[Nature Communications] Investigators identified vesicle-associated membrane protein 5 as a potent cell-autonomous defense factor against coronaviruses, including SARS-CoV-2, with high expression levels observed in embryonic stem cells and mesoderm.
Structural and Functional Analyses of SARS-CoV-2 Nsp3 and Its Specific Interactions With the 5′ UTR of the Viral Genome
[Microbiology Spectrum] Investigators suggested that multiple domains of Nsp3, particularly Ubl1 and Y, shepherd the 5’ UTR of the viral genome during translocation through the DMV membrane, priming the Ubl1 domain to load the genome onto N protein.
Durable Immune Response and Long-Term Efficacy of COVID-19 Vaccination in Children with Inflammatory Bowel Disease
[Inflammatory Bowel Diseases] Investigators described outcomes among those who developed SARS-CoV-2 infection following vaccination, characterize SARS-CoV-2 antibodies 1 year post-vaccination, and identify factors associated with durable serologic response.
Intranasal Booster Induces Durable Mucosal Immunity Against SARS-CoV-2 in Mice
[Scientific Reports] Researchers compared immune responses elicited by intramuscular mRNA vaccination alone with those elicited by intramuscular mRNA vaccination followed by intranasal administration of ChAdOx1 nCoV-19 vaccine in mice.
Long COVID Syndrome: Exploring Therapies for Managing and Overcoming Persistent Symptoms
[Inflammopharmacology] Researchers examine the epidemiology, risk factors, and clinical manifestations of long COVID, with a focus on its impact on cardiopulmonary, neurological, and mental health.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
