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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Simultaneous Priming of HIV Broadly Neutralizing Antibody Precursors to Multiple Epitopes by Germline-Targeting mRNA-LNP Immunogens in Mouse Models
[Science Immunology] Scientists used preclinical mouse models with physiologically relevant frequencies of broadly neutralizing antibody precursor–bearing B cells to compare precursor elicitation by coadministration of multiple protein or mRNA lipid nanoparticle germline-targeting immunogens.
Withaferin a Inhibits EBV-Driven Lymphomagenesis through Multiple Mechanisms, Including EBNA1 Degradation
[Blood] Across a panel of lymphoma cell lines, Withaferin A demonstrated selective cytotoxicity toward Epstein-Barr virus (EBV)-positive B cell non-Hodgkin lymphomas in part through proteasome-dependent degradation of EBV nuclear antigen 1 (EBNA1) and subsequent loss of viral episomes, alongside additional effects on cellular stress and survival pathways.
A Choline-Sensing Regulator Coordinates Metabolic Adaptation and Pathogenesis in Pulmonary Infections
[Science Advances] Researchers demonstrate that choline (Cho)–induced regulator (CodR), a GcvA-type transcriptional regulator, serves as a master regulator integrating virulence, antibiotic resistance, and phosphatidylcholine catabolism during pulmonary infection.
Bacterial Communities Co-Develop with Respiratory Immunity Early in Life, Linking Dysbiosis to Systemic Monocyte Signature, and Wheezing
[Science Advances] In a prospective birth cohort of 256 infants, researchers profiled bacterial, fungal, and viral communities in the upper airway and assessed local immune gene expression longitudinally and systemic gene expression at 1 year.
Antiviral Strategies against H5N1: Current Options and Emerging Therapeutics
[Infection] Expanding the antiviral armamentarium through accelerated evaluation and integration of both traditional and innovative compounds will be essential to pandemic preparedness and effective H5N1 outbreak response.
Computationally Designed mRNA-Launched Protein Nanoparticle Immunogens Elicit Protective Antibody and T Cell Responses in Mice
[Science Translational Medicine] Using SARS-CoV-2 as a model system, researchers genetically fused a stabilized variant of the Wuhan-Hu-1 spike protein receptor binding domain to a protein nanoparticle they previously designed for optimal secretion from human cells.
Nucleic Acid-Protein Condensates in Innate Immunity
[Molecular Cell] The authors discuss advances in the field that address the relationship between RNA/DNA-protein co-condensates and innate immune regulation.
Microtubule Remodeling by the Innate Immune Factor Trim69 Compromises Dynein-Dependent Migration of HIV Virion Cores toward the Nucleus
[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrate that by binding and remodeling microtubules (MTs), Trim69 inhibits the docking and the migration of virion cores on MTs by promoting the stalling of the dynein/dynactin motor complexes.
Gravity-Perfused Airway-on-a-Chip Optimized for Quantitative BSL-3 Studies of SARS-CoV-2 Infection: Barrier Permeability, Cytokine Production, Immunohistochemistry, and Viral Load Assays
[Lab on a Chip] Scientists created a human airway organ chip that could operate in a Biosafety Level 3 space with high throughput and minimal manipulation, while retaining the necessary physical and physiological components to recapitulate tissue response to infectious agents and the immune response to infection.
Neutrophils from Protection to Pathogenesis in Tuberculosis
[ACS Infectious Diseases] The abundance of neutrophils in tuberculosis (TB) granulomas and their correlation with disease severity in humans and animal models suggest a vital role for these immune cells in TB infection.
Mycobacterium Tuberculosis-Specific T Cells Restrain Anti-Cancer Drug-Induced Neutrophilic Lung Inflammation in Tuberculosis
[Nature Communications] Mice infected with Mycobacterium tuberculosis (Mtb) were treated with gemcitabine, cisplatin, or paclitaxel. These treatments delay Mtb-specific T cell responses, increase bacterial loads, and cause hyperinflammation with permissive neutrophils in the lungs.
Immunodominant T Cell Responses to SARS-CoV-2 Nucleocapsid Protein in Omicron Breakthrough Infection Post-Inactivated Vaccination
[Virulence] The authors found that early Omicron subvariant breakthrough infections elicited robust CD4+ and CD8+ T cell responses specific to the JN.1 N protein, characterized by Th1/Tc1-skewed phenotype and preserved polyfunctionality.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
