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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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DDX17 and Viral Infection
[Virulence] The authors uncover the unique roles of DEAD-box RNA helicase 17 (DDX17) in diverse viral infections through a comprehensive review of existing studies and explores its prospects as a therapeutic target for antiviral interventions.
Houston Methodist Partners with CEPI and International Scientific Institutions to Advance First AI-Designed mRNA Vaccine against Deadly Tick-Borne Disease
[Houston Methodist Research Institute] Houston Methodist Research Institute is collaborating with the Coalition for Epidemic Preparedness Innovations and leading scientific institutions in the Republic of Korea to develop what could become the world’s first mRNA vaccine against severe fever with thrombocytopenia syndrome, a tick-borne viral disease associated with this condition.
Harnessing Virus-Specific T Cells: Expanding Therapeutic Strategies across Diverse Populations
[Blood Advances] Scientists explore the manufacturing, feasibility, safety, and efficacy of virus-specific T cells (VST). They examine recent advancements in VST manufacturing that broaden their accessibility and applicability to a wider range of viral infections and immunocompromised populations.
Predictive Markers of SARS-CoV-2 Spike-Specific Cytotoxic T Cell Activity Following Omicron Breakthrough Infection
[Emerging Microbes & Infections] Researchers investigated the impact of Omicron breakthrough infection on S-specific cellular immunity, including polyfunctional CD8+ T cell and cytotoxic T lymphocyte levels of 28 previously uninfected individuals vaccinated either two or three times against SARS-CoV-2.
Stem-Like CD8+ T Cells Preserve HBV-Specific Responses in HBV/HIV Co-Infection
[Gut] Scientists investigated CD8+ T cell profiles in hepatitis B virus (HBV) mono-infection versus HBV/HIV co-infection, examining the impact of long-term therapy on virus-specific responses to inform therapeutic strategies for immune restoration.
Dietary Restriction Reprograms CD8+ T Cell Fate to Enhance Anti-Tumor Immunity and Immunotherapy Responses
[Nature Metabolism] Using syngeneic xenograft tumour models, scientists found that dietary restriction induced a profound reprogramming of CD8+ T cell fate in the tumor microenvironment, favouring the expansion of effector T cell subsets with enhanced metabolic capacity and cytotoxic potential, while limiting the accumulation of terminally exhausted T cells.
Pre-Existing and Early Cellular Immune Factors Correlate with Functionally Complete Protection against Primary Controlled Human SARS-CoV-2 Infection
[Nature Communications] Scientists analyzed pre- and early post-exposure immune factors associated with resisting SARS-CoV-2 infection after human challenge in seronegative individuals, using multiplex protein, cytometric and RNA sequencing approaches in the nasopharynx and circulation.
Influenza Vaccines Promote Humoral and Cellular Immune Responses: A Randomized, Double-Blind, Phase 3 Trial
[Nature Communications] Researchers reported findings from a randomized, double-blind, active-controlled Phase III clinical trial that includes 334 healthy adults aged 18–64 years and evaluates the humoral and cellular antiviral immune responses induced by two inactivated quadrivalent influenza vaccines.
CD44 Cross-Linking Promotes Plasmodium Falciparum Invasion
[Nature Communications] The authors identified an anti-CD44 monoclonal antibody, BRIC 222, that significantly promotes P. falciparum invasion through CD44 cross-linking.
Nef Stabilizes Actin to Prevent HIV-1 Sensing by RIG-I-Like Receptors
[Nature Communications] Investigators showed that the HIV-1 accessory protein Nef prevents R12C-mediated RIG-I-like receptor priming, thereby suppressing viral sensing.
Single-Cell Multi-Omic Landscape Reveals Anatomical-Specific Immune Features in Adult and Pediatric Sepsis
[Nature Immunology] Researchers applied multi-omic profiling to analyze peripheral blood mononuclear cells and plasma from 281 adult and pediatric individuals with sepsis and controls.
ARCN1 Suppresses Innate Immune Responses against Respiratory Syncytial Virus by Promoting STUB1-Mediated IKKε Degradation
[PLoS Pathogens] Researchers demonstrated that archain 1 (ARCN1) suppresses the anti-Respiratory syncytial virus innate immune response by promoting E3 ubiquitin ligase STUB1-mediated K48-linked polyubiquitination and subsequent proteasomal degradation of IKKε.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
