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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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14-3-3ε-Dependent Deubiquitination and Translocation of NLRP3 Activates the Inflammasome during Sepsis
[JCI Insight] Researchers found that 14-3-3ε facilitates NLRP3 inflammasome activation by enhancing NLRP3 K63 deubiquitination and promoting its translocation to the mitochondria-associated ER membranes for full activation.
RhCMV Expands CCR5+ Memory T Cells and Promotes SIV Reservoir Seeding in the Gut Mucosa
[JCI Insight] Researchers examined acute phase immune and virological dynamics in cohorts of SIV-infected rhesus macaques that were naturally seropositive or -negative for rhesus CMV (RhCMV).
Pathology and Viral Evolutionary Dynamics in a Hamster Model of Persistent SARS-CoV-2 Infection
[Communications Biology] Investigators described a model of SARS-CoV-2 persistence using transgenic Syrian hamsters lacking the interleukin-2 receptor gamma subunit.
Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways
[Cell Death Discovery] Scientists investigated the effects of Tetrandrine on SARS-CoV-2 infection in human lung epithelial cells, with a particular focus on autophagy-related mechanisms.
Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways
[Cell Death Discovery] Scientists investigated the effects of Tetrandrine on SARS-CoV-2 infection in human lung epithelial cells, with a particular focus on autophagy-related mechanisms.
Protective Role of PCED1B-Expressing Naive CD4+ T Cells in Sepsis
[Chinese Medical Journal] Researchers profiled the immune cell landscape in sepsis using scRNA-seq analysis, focusing on the significantly reduced naive CD4+ T cells.
Ebola Virus Matrix Protein VP40 Triggers Inflammatory Responses Linked to the Ebolavirus Virulence
[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that highly virulent Ebola virus induced a high and sustained pro-inflammatory response compared to less virulent ebolaviruses in non-mononuclear phagocytes through TLR4-independent NF-κB activation.
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
[Annual Review of Immunology] The authors characterize the activity of type III interferons on distinct cell types in different tissues and organs and detail their impact for the host in the context of viral, bacterial, helminth, and fungal infections.
IgA-Driven Neutrophil Activation Underlies Severe Dengue Disease after Primary Zika Virus Infection in Humans
[Nature Immunology] Leveraging a long-standing Pediatric Dengue Cohort Study in Nicaragua, researchers showed that anti-NS1 immunoglobulin A antibodies in plasma, elicited after a primary Zika flavivirus infection, drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease.
CD8+ T Cell Immunity in HIV Cure and Prevention: Linking Stemness, Spatial Niches, and Emerging Therapeutic Strategies
[Annual Review of Immunology] The authors highlight emerging insights, informed by novel clinical trial frameworks, into CD8+ T cell dynamics during acute HIV infection, early therapy, and treatment interruption.
Autophagic Extracellular Vesicles (AEVs) Are Distinct from Exosomes and Play Crucial Roles in Viral Infections
[Nature Communications] Scientists confirmed that the enteroviral particles or genomes can be encapsulated into a subtype of small extracellular vesicles, termed autophagic extracellular vesicles, and subsequently infect receptor-negative cells with high efficiency.
Interleukin-2 Is a Potent Latency Reversal Agent in People with Treated HIV-1
[Science Advances] The authors asked whether administration of recombinant interleukin-2 to people with HIV-1 on antiretroviral therapy would induce HIV-1 replication and activate cellular immunity.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
