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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Targeting ATP2B1 Impairs PI3K/Akt/FOXO Signaling and Reduces SARS-COV-2 Infection and Replication
[EMBO Journal] Researchers demonstrated that a nontoxic caloxin-derivative compound reduced intracellular Ca2+ levels and impairs SARS-CoV-2 infection.
An IFNγ-Dependent Immune–Endocrine Circuit Lowers Blood Glucose to Potentiate the Innate Antiviral Immune Response
[Nature Immunology] Scientists showed that strong, nonlethal infection restricted systemic glucose availability, which promoted the antiviral type I (IFN) interferon response.
Aripiprazole As Protector Against COVID-19 Mortality
[Scientific Reports] Investigators aimed to prove whether antipsychotics might exert adverse or protective effects against fatal outcomes derived from COVID-19. Two sub-cohorts were delineated, comprising a total of 2536 inpatients: individuals who either had no prescription medication or were prescribed an antipsychotic within the 15 days preceding hospitalization.
3D Bioprinting Platform Development for High-Throughput Cancer Organoid Models Construction and Drug Evaluation
[Biofabrication] Investigators presented a novel composite bioink for culturing colorectal cancer organoids that provided an environment close to real tissue growth conditions and exhibited excellent photocrosslinking properties for rapid gel formation.
Evaluation of the Efficacy and Safety of Intravenous Immunoglobulin (IVIG) in Moderate-to-Severe Hospitalized COVID-19 Patients: A Randomized, Open-Label Parallel-Group Study
[Canadian Journal of Infectious Diseases & Medical Microbiology] This randomized study included 59 moderate-to-severe COVID-19 patients with known comorbidities. One arm received high-dose intravenous immunoglobulins within 48 hours for five days alongside standard of care (SoC), while the other arm received SoC, comprising steroids, enoxaparin, and remdesivir.
Initial COVID-19 Severity Influenced by SARS-CoV-2-Specific T Cells Imprints T-Cell Memory and Inversely Affects Reinfection
[Signal Transduction and Targeted Therapy] Investigators longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by severity. They found that early and robust SARS-CoV-2-specific CD4+ and CD8+ T cell responses ameliorate disease progression and shortened hospital stay, while delayed and attenuated virus-specific CD8+ T cell responses are prominent severe COVID-19 features.
Kinetics of SARS-CoV-2 Infection Biomarkers in a Household Transmission Study
[Scientific Reports] Researchers conducted a field study to evaluate SARS-CoV-2 viral marker kinetics starting from very early times after infection.They measured RNA and antigen levels in nasal swabs and saliva, virus outgrowth in cell culture from nasal swabs, and antibody levels in blood in a cohort of 30 households.
Chronic Immune Activation and Accelerated Immune Aging Among HIV-Infected Adults Receiving Suppressive Antiretroviral Therapy for at Least 12 Years in an African Cohort
[Heliyon] Investigators described immune aging phenotypes among antiretroviral therapy-treated HIV-infected adults relative to age-matched HIV-negative counterparts.
The Alarmin IL-33 Exacerbates Pulmonary Inflammation and Immune Dysfunction in SARS-CoV-2 Infection
[iScience] Researchers observed that IL-33, a damage-associated molecular pattern molecule, was significantly increased in COVID-19 patients and in SARS-CoV-2-infected mice.
Multiple Sclerosis Patient-Derived Spontaneous B Cells Have Distinct EBV and Host Gene Expression Profiles in Active Disease
[Nature Microbiology] Researchers characterized spontaneous lymphoblastoid cell lines isolated from multiple sclerosis patients and healthy controls ex vivo to study Epstein–Barr virus (EBV) and host gene expression in the context of an individual’s endogenous EBV.
Twin Cities Lyme Foundation and Bay Area Lyme Foundation Unite Efforts to Further Advance the Fight Against Tick-Borne Diseases
[Bay Area Lyme Foundation] Bay Area Lyme Foundation announced it has united efforts with Twin Cities Lyme Foundation (TCLF) to further advance the fight against tick-borne diseases in the Midwest. Lisa and Peter Najarian carefully created a thoughtful charitable foundation in their quest for an accurate diagnostic and a desire to educate physicians with information about tick-borne diseases.
HIV and Cardiovascular Disease
[Circulation Research] The authors explore the current state of knowledge in HIV and cardiovascular disease, exploring risk factors, therapies, and future research directions.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
