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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
The Membrane-Associated Ubiquitin Ligases MARCH2 and MARCH3 Target TIM-1 to Limit Zika Virus Infection
[Cellular & Molecular Immunology] Researchers identified the membrane-associated RING-CH-type finger (MARCH) E3 ubiquitin ligase family members MARCH2 and MARCH3 as critical negative regulators of TIM-1 under physiological conditions.
Multiscale Dynamic Immunomodulation by a Nanoemulsified Trojan-TLR7/8 Adjuvant for Robust Protection against Heterologous Pandemic and Endemic Viruses
[Cellular & Molecular Immunology] squalene nanoemulsion(Trojan-TLR7/8a) suggested herein provided a novel vaccine design principle for dynamic modulation at the multiscale level and demonstrates long-term and broad protective immunity against emerging pandemic and endemic infectious viruses.
Salmonella Typhimurium Exploits the Reticulophagy/ERphagy Receptor RETREG1 to Promote Infection
[Autophagy] Investigators found that Salmonella enterica Serovar Typhimurium, a well-known intracellular pathogen that continues to be a major cause of foodborne infections worldwide, inhibits ERphagy by specifically targeting the activity of RETREG1, leading to a pronounced increase in Salmonella burden.
Rational Design of Broad-Spectrum Antimicrobial Peptides Derived from the Dengue Virus Capsid Alpha2 Sequence
[ACS Applied Materials & Interfaces] Researchers designed a group of amphiphilic antimicrobial peptides (AMPs) based on the α2 sequence of a Dengue viral capsid protein to address the challenge of ineffective membrane disruptions of AMPs.
Identification of Epstein-Barr Virus BORF2 Sequences Required for APOBEC3B Relocalization
[Journal of Virology] Scientists found that a SUMO-modified site in BORF2 plays an important role in the formation of bodies with endogenous APOBEC3B, both when expressed on its own and in the context of Epstein-Barr Virus infection.
Lesser-Known Non-Apoptotic Programmed Cell Death in Viral Infections
[Virus Research] Researchers focused on four key non-apoptotic programmed cell death types, including ferroptosis, cuproptosis, NETosis, and PANoptosis, and summarize their distinct molecular pathways and roles during viral infections.
Muscle-Targeting LNP Vaccines Enable Potent Immune Responses against Varicella Zoster Virus
[Drug Delivery and Translational Research] After encapsulating varicella zoster virus glycoprotein E-encoding mRNA, three lipid nanoparticles formulations induced robust humoral and cellular immune responses specific to the gE antigen, demonstrated improved selectivity and immunogenicity compared to SM-102, the ionizable lipid used in Moderna’s Spikevax.
Antibody and B-Cell Responses to PHH-1V81 XBB.1.16-Adapted SARS-CoV-2 Booster Vaccination Are Associated with Variant Neutralization
[Journal of Medical Virology] Investigators assessed the antibody B-cell response in 40 individuals receiving either the PHH-1V81 XBB.1.16- or BNT162b2 XBB.1.5-adapted vaccine boosters.
Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients with Long COVID
[Journal of Medical Virology] The authors assessed IgG, IgA, and IgM antibody levels against SARS-CoV-2, seasonal coronaviruses, and herpesviruses using ELISAs and Microblot-Array panels.
Investigating Alveolar Macrophages in an Human Ex Vivo Precision-Cut Lung Slice Model of SARS-CoV-2 Infection Using Raman Spectroscopy-a Case Study
[Clinical and Translational Medicine] Human precision-cut lung slices from one donor were infected with either the SARS-CoV-2 delta or omicron variant. Immunofluorescence microscopy localized alveolar macrophages and virus particles.
Exploiting Host Kinases to Combat Dengue Virus Infection and Disease
[Antiviral Research] The authors summarize findings on the role of kinases in dengue infection and disease and highlight potential kinase targets for the development of innovative host-directed therapeutics.
Doctors Renew Push for Free COVID Shots for More Albertans, after Coverage Reinstated for Health Workers
[CBC News] Doctors are renewing their calls for the Alberta government to offer the COVID-19 vaccine for free to anyone who wants it, now that the province has agreed to cover health-care workers.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
