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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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The Infection Enigma: Why Some People Die from Typically Harmless Germs
[Nature] Millions of people worldwide carry genetic mutations that weaken their immune system.
A Distinct Monocyte Transcriptional State Links Systemic Immune Dysregulation to Pulmonary Impairment in Long COVID
[Nature Immunology] Researchers integrated single-cell multiome data, immunological profiling, and functional assays to investigate immune alterations across multiple cohorts.
Harvard Chan Researchers Win $100 Million MacArthur Grant for Infectious Disease Surveillance System
[Harvard School of Public Health] The John D. and Catherine T. MacArthur Foundation awarded its $100 million “100&Change” grant to the Sentinel project, an infectious disease surveillance system designed to help communities identify outbreaks and prevent potential pandemics.
Hershey Medical Center Earns Grant to Boost Rare, High-Risk Infection Readiness
[Pennsylvania State University] Penn State Health Milton S. Hershey Medical Center is expanding its ability to safely care for patients with rare, high‑risk infectious diseases as part of its ongoing role as a Level 2 Special Pathogen Treatment Center, thanks to a new $500,000 federal grant.
Intranasal Replicon Vaccine Establishes Mucosal Immunity and Protects against H5N1 and H7N9 Influenza
[Nature Communications] Researchers described monovalent and bivalent replicon vaccines against A/Vietnam/1203/2004 H5N1 and A/Anhui/PA-1/2013 H7N9.
Dynamic Regulation of TBK1 Lactylation Shapes Antiviral Immune Responses
[Cellular & Molecular Immunology] Investigators revealed a dynamic regulatory network involving lactylation–delactylation of TANK binding kinase 1 (TBK1), a pivotal kinase of IFN-I signaling, that finely tunes antiviral immune responses.
Intranasal Unadjuvanted LcrV Boosts Parental Yersinia OMV Primed Lung Immunity against Pneumonic Plague in Mice
[Nature Communications] The authors showed that intramuscular prime-boost vaccination with Alum-absorbed OMV46-LcrV is safe but provides limited long-term protection against respiratory Yersinia pestis challenge in mice.
14-3-3ε-Dependent Deubiquitination and Translocation of NLRP3 Activates the Inflammasome during Sepsis
[JCI Insight] Researchers found that 14-3-3ε facilitates NLRP3 inflammasome activation by enhancing NLRP3 K63 deubiquitination and promoting its translocation to the mitochondria-associated ER membranes for full activation.
RhCMV Expands CCR5+ Memory T Cells and Promotes SIV Reservoir Seeding in the Gut Mucosa
[JCI Insight] Researchers examined acute phase immune and virological dynamics in cohorts of SIV-infected rhesus macaques that were naturally seropositive or -negative for rhesus CMV (RhCMV).
Pathology and Viral Evolutionary Dynamics in a Hamster Model of Persistent SARS-CoV-2 Infection
[Communications Biology] Investigators described a model of SARS-CoV-2 persistence using transgenic Syrian hamsters lacking the interleukin-2 receptor gamma subunit.
Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways
[Cell Death Discovery] Scientists investigated the effects of Tetrandrine on SARS-CoV-2 infection in human lung epithelial cells, with a particular focus on autophagy-related mechanisms.
Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways
[Cell Death Discovery] Scientists investigated the effects of Tetrandrine on SARS-CoV-2 infection in human lung epithelial cells, with a particular focus on autophagy-related mechanisms.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
