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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Computationally Designed mRNA-Launched Protein Nanoparticle Immunogens Elicit Protective Antibody and T Cell Responses in Mice
[Science Translational Medicine] Using SARS-CoV-2 as a model system, researchers genetically fused a stabilized variant of the Wuhan-Hu-1 spike protein receptor binding domain to a protein nanoparticle they previously designed for optimal secretion from human cells.
Nucleic Acid-Protein Condensates in Innate Immunity
[Molecular Cell] The authors discuss advances in the field that address the relationship between RNA/DNA-protein co-condensates and innate immune regulation.
Microtubule Remodeling by the Innate Immune Factor Trim69 Compromises Dynein-Dependent Migration of HIV Virion Cores toward the Nucleus
[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrate that by binding and remodeling microtubules (MTs), Trim69 inhibits the docking and the migration of virion cores on MTs by promoting the stalling of the dynein/dynactin motor complexes.
Gravity-Perfused Airway-on-a-Chip Optimized for Quantitative BSL-3 Studies of SARS-CoV-2 Infection: Barrier Permeability, Cytokine Production, Immunohistochemistry, and Viral Load Assays
[Lab on a Chip] Scientists created a human airway organ chip that could operate in a Biosafety Level 3 space with high throughput and minimal manipulation, while retaining the necessary physical and physiological components to recapitulate tissue response to infectious agents and the immune response to infection.
Neutrophils from Protection to Pathogenesis in Tuberculosis
[ACS Infectious Diseases] The abundance of neutrophils in tuberculosis (TB) granulomas and their correlation with disease severity in humans and animal models suggest a vital role for these immune cells in TB infection.
Mycobacterium Tuberculosis-Specific T Cells Restrain Anti-Cancer Drug-Induced Neutrophilic Lung Inflammation in Tuberculosis
[Nature Communications] Mice infected with Mycobacterium tuberculosis (Mtb) were treated with gemcitabine, cisplatin, or paclitaxel. These treatments delay Mtb-specific T cell responses, increase bacterial loads, and cause hyperinflammation with permissive neutrophils in the lungs.
Immunodominant T Cell Responses to SARS-CoV-2 Nucleocapsid Protein in Omicron Breakthrough Infection Post-Inactivated Vaccination
[Virulence] The authors found that early Omicron subvariant breakthrough infections elicited robust CD4+ and CD8+ T cell responses specific to the JN.1 N protein, characterized by Th1/Tc1-skewed phenotype and preserved polyfunctionality.
Alpha Hemolysin Enhances the Immune Response by Modulating Dendritic Cell Differentiation via ADAM10-Notch Signaling
[Signal Transduction and Targeted Therapy] Investigators demonstrated that the HlaH35A fusion enhances vaccine efficacy by targeting A Disintegrin and Metalloproteinase 10 (ADAM10) on dendritic cells, thereby activating the ADAM10-Notch signaling axis.
Cross-Neutralizing and Potent Human Monoclonal Antibodies against Historical and Emerging H5Nx Influenza Viruses
[Nature Microbiology] Scientists described the isolation and characterization of broadly cross-neutralizing monoclonal antibodies against diverse H5Nx viruses from individuals who received a monovalent H5N1 vaccine 15 years ago.
UCF Researchers Developing Easy-to-Use Viral Biosensor Test — Giving Patients More Accurate, Immediate Results
[UCF] An interdisciplinary team of University of Central Florida (UCF) researchers is creating a single low-cost test to detect HIV and Hepatitis B and C simultaneously, which may save lives in resource-limited settings.
How Malaria Harms Unborn Babies
[Max Delbrück Center] UK-based Wellcome has awarded over €2 million to an international research effort to uncover how malaria can injure developing babies. Dr. Emanuel Wyler at the Max Delbrück Center will play a key role in studying the molecular interaction between the parasite Plasmodium falciparum and the placenta.
CD8+ Lymphocytes in Immunity against Tuberculosis
[The Journal of Immunology] Understanding the heterogeneity of CD8+ lymphocyte responses and dynamics in Tuberculosis can provide critical insights for designing efficacious vaccines and immunotherapies while minimizing immunopathology.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
