Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
6445212 VERRAMLV items 1 apa default asc 1
By using ex vivo 3D organoid cultures and molecular approaches scientists observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
6445212 QARUV3UB items 1 apa default asc 1
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Nevé, C. L., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. Development. https://doi.org/10.1242/dev.194357 Cite
Quantitative real-time PCR, western blot and immunohistochemistry were utilized to detect the expression profiles and prognostic significance of SPHK2 in gastric cancer.
Scientists investigated whether luteolin exhibits its anticancer effects by induction of apoptosis and autophagy in a p53-dependent manner in colon cancer cells.
[Nutrition and Cancer-An International Journal]
Neoadjuvant therapy is becoming the standard of care for an increasing number of tumor types. Currently, colon cancer patients are still routinely treated with up-front surgery, and neoadjuvant systemic therapy is not yet standard.
[Cancer Management and Research]
6445212 7CB7Z6TC items 1 apa default asc 1
The characteristic surface markers of cancer stem cells and the related mechanism of drug resistance are discussed in detail by the authors.
The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
6445212 48F7TIS6 items 1 apa default asc 1
Xia, Y., Lv, J., Jiang, T., Li, B., Li, Y., He, Z., Xuan, Z., Sun, G., Wang, S., Li, Z., Wang, W., Wang, L., & Xu, Z. (2021). CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization. Journal of Experimental & Clinical Cancer Research, 40(1), 103. https://doi.org/10.1186/s13046-021-01896-9 Cite
The authors studied the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations and explored the effect of increased MSI1 levels in response to treatment.
6445212 SCBMXDE5 items 1 apa default asc 1
Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Neve, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., Fouchardière, C. de la, & Plateroti, M. (2021). Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2450 Cite
Researchers showed that the cytoplasmic pool of fat mass and obesity-associated protein impeded cancer stem cellabilities in colorectal cancer through its N6,2’-O-dimethyladenosine (m6Am) demethylase activity.
6445212 68HLQZH4 items 1 apa default asc 1
Relier, S., Ripoll, J., Guillorit, H., Amalric, A., Achour, C., Boissière, F., Vialaret, J., Attina, A., Debart, F., Choquet, A., Macari, F., Marchand, V., Motorin, Y., Samalin, E., Vasseur, J.-J., Pannequin, J., Aguilo, F., Lopez-Crapez, E., Hirtz, C., … David, A. (2021). FTO-mediated cytoplasmic m 6 A m demethylation adjusts stem-like properties in colorectal cancer cell. Nature Communications, 12(1), 1716. https://doi.org/10.1038/s41467-021-21758-4 Cite
The authors analyzed the CXCL8-CXCR1/2 axis related signaling pathways and ncRNAs in ulcerative colitis (UC), as well as recent advances in our understanding of the CXCL8-CXCR1/2 axis inhibition as a therapeutic strategy against UC.
[Biomedicine & Pharmacotherapy]
Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
6445212 J5JGKVUV items 1 apa default asc 1