Multilevel Regulation of Wnt Signaling by Zic2 in Colon Cancer Due to Mutation of β-Catenin

Researchers demonstrated that Zic2 was highly expressed in colon cancer tissues and correlated with poor survival. Knockdown of Zic2 inhibited colon cancer cell growth, arrested the cell cycle transition from G0/G1 to S phase, and suppressed tumor sphere formation in vitro.
[Cell Death & Disease]
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miR-802 Regulates Paneth Cell Function and Enterocyte Differentiation in the Mouse Small Intestine

Investigators showed that the intestine-enriched miR-802 was a central regulator of intestinal epithelial cell proliferation, Paneth cell function, and enterocyte differentiation.
[Nature Communications]
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LncRNA Bmp1 Promotes the Healing of Intestinal Mucosal Lesions via the miR-128-3p/PHF6/PI3K/AKT Pathway

The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease]
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Assessment of Copy Number in Protooncogenes Are Predictive of Poor Survival in Advanced Gastric Cancer

Researchers characterized the clinicopathological features, including prognosis, of gastric carcinomas with copy number gains in multiple protooncogenes.
[Scientific Reports]
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Genetic and Commensal Induction of IL-18 Drive Intestinal Epithelial MHCII via IFNγ

Scientists linked intestinal dysbiosis, systemic inflammation, and inflammasome activity to intestinal epithelial cells major histocompatibility complex class II upregulation via an intestinal serum Interleukin-18-interferon gamma axis.
[Mucosal Immunology]
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Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
[Nature Communications]
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Organoids and Organs-on-Chips: Insights into Human Gut-Microbe Interactions

The authors review recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models.
[Cell Host & Microbe]
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The Role of Polyamines in Gastric Cancer

Investigators summarize the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function.
[Oncogene]
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Microscopic Colitis

This microscopic colitis review discusses the understanding of the immune response, genetics and the microbiome in disease pathogenesis along with progress in disease management through robust clinical trials.
[Nature Reviews Disease Primers]
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αSMA+ Fibroblasts Suppress Lgr5+ Cancer Stem Cells and Restrain Colorectal Cancer Progression

Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exert tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
[Oncogene]
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RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy

Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research]
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