CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports]
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Adaptive Differentiation Promotes Intestinal Villus Recovery

Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.
[Developmental Cell]
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Immune Subtypes and Neoantigen-Related Immune Evasion in Advanced Colorectal Cancer

Scientist analyzed immune subtypes and immune evasion via neoantigen-related mechanisms. They identified a distinctive cancer subtype characterized by immune evasion and very poor overall survival.
[iScience]
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Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells

Investigator employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human ISCs from the duodenum and rectum.
[Nature Communications]
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Transcriptomic Profiling of Single Circulating Tumor Cells Provides Insight into Human Metastatic Gastric Cancer

Researchers utilized an antigen-independent strategy for circulating tumor cell (CTC) isolation from metastatic gastric cancer patients involving a size-dependent recovery of CTCs and a single cell isolation technique.
[Communications Biology]
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Linc01133 Contributes to Gastric Cancer Growth by Enhancing YES1-Dependent YAP1 Nuclear Translocation via Sponging miR-145-5p

Scientists found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients.
[Cell Death & Disease]
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GPR120 Prevents Colorectal Adenocarcinoma Progression by Sustaining the Mucosal Barrier Integrity

Researchers explored the involvement of epithelial GPR120 in the colorectal cancer development. Both in vitro and in vivo experiments were conducted to mimic the conditional deletion of the receptor from gut epithelium.
[Scientific Reports]
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Functional Roles of Cytokines in Infectious Disease Associated Colorectal Carcinogenesis

IL-21 has profound effects on tumor growth and immunosurveillance of colitis-associated tumourigenesis, thereby emphasising its involvement in the pathogenesis of colorectal cancer.
[Molecular Biology Reports]
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Intestinal Gpr17 Deficiency Improves Glucose Metabolism by Promoting GLP-1 Secretion

Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.
[Cell Reports]
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Emerging Targetome and Signalome Landscape of Gut Microbial Metabolites

The authors discuss strategies and open questions for mining and biomimicking the microbial metabolite-targetome interactions for pharmacological manipulation, which may lead to a new paradigm of drug discovery.
[Cell Metabolism]
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Tissue Geometry Drives Deterministic Organoid Patterning

Scientists developed approaches for specifying the initial organoid geometry to build intestinal organoids of defined shape, size, and cell distributions, forming structures that were predictable, more similar to normal organs, and reproducible.
[Science]
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