Application of Smart Solid Lipid Nanoparticles to Enhance the Efficacy of 5-Fluorouracil in the Treatment of Colorectal Cancer

The solid lipid nanoparticle(SLN)-loaded 5-FU was developed by utilizing a Strategic and unique Method to Advance and Refine the Treatment of colorectal cancer through hot and cold homogenization approach. The SLN was made of unique PEGylated lipids and combination of the surfactants.
[Scientific Reports]
Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer | Scientific Reports. (n.d.). Retrieved October 15, 2020, from https://www.nature.com/articles/s41598-020-73218-6 Cite
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LncRNA SNHG11 Promotes Gastric Cancer Progression by Activating Wnt/β-Catenin Pathway and Oncogenic Autophagy

Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
[Molecular Therapy]
LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
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Cir-ITCH Inhibits Gastric Cancer Migration, Invasion and Proliferation by Regulating the Wnt/β-Catenin Pathway

cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
[Scientific Reports]
Peng, Y., & Wang, H. H. (2020). Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/β-catenin pathway. Scientific Reports, 10(1), 17443. https://doi.org/10.1038/s41598-020-74452-8 Cite
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TAp63α Targeting of Lgr5 Mediates Colorectal Cancer Stem Cell Properties and Sulforaphane Inhibition

Researchers investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
[Oncogenesis]
Chen, Y., Wang, M., Zhu, J., Xie, C., Li, X., Wu, J., Geng, S., Han, H., & Zhong, C. (2020). TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition. Oncogenesis, 9(10), 1–11. https://doi.org/10.1038/s41389-020-00273-z Cite
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SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness

Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
[Cancer Research]
Wang, T.-W., Chern, E., Hsu, C.-W., Tseng, K.-C., & Chao, H.-M. (2020). SIRT1-mediated expression of CD24 and epigenetic suppression of novel tumor suppressor miR-1185-1 increases colorectal cancer stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-3188 Cite
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B7-H3 Regulates KIF15-Activated ERK1/2 Pathway and Contributes to Radioresistance in Colorectal Cancer

In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
[Cell Death & Disease]
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 6, 2020, from https://www.nature.com/articles/s41419-020-03041-4 Cite
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Heat Treatment of Galangin and Kaempferol Inhibits Their Benefits to Improve Barrier Function in Rat Intestinal Epithelial Cells: Galangin & Kaempferol Improve IEC-6 Cells Barrier Function

In this study, two flavonols galangin and kaempferol were heated at 100°C for 30 min prior to assessing their effects on barrier function of rat intestinal epithelial (IEC-6) cells.
[Journal of Nutritional Biochemistry]
Fan, J., Zhao, X.-H., & Li, T.-J. (2020). Heat treatment of galangin and kaempferol inhibits their benefits to improve barrier function in rat intestinal epithelial cells: Galangin & kaempferol improve IEC-6 cells barrier function. The Journal of Nutritional Biochemistry, 108517. https://doi.org/10.1016/j.jnutbio.2020.108517 Cite
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Non-Muscle Myosin-2 Contractility-Dependent Actin Turnover Limits the Length of Epithelial Microvilli

Using pharmacological and genetic perturbations in cultured intestinal epithelial cells, investigators found that non-muscle myosin-2C controls the length of growing microvilli by regulating actin turnover in a manner that requires a fully active motor domain.
[Molecular Biology of the Cell]
Chinowsky, C. R., Pinette, J. A., Meenderink, L. M., Lau, K. S., & Tyska, M. J. (2020). Non-muscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli. Molecular Biology of the Cell, mbc.E20-09-0582. https://doi.org/10.1091/mbc.E20-09-0582 Cite
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A Novel Role for Farnesoid X Receptor in the Bile Acid‐Mediated Intestinal Glucose Homeostasis

Bile acid‐activated farnesoid X receptor enhanced glucose uptake in intestinal epithelial cells by increasing the expression of glucose transporter 2, which depended on ERK1/2 phosphorylation via S1PR2. However, it also reduced the cell energy generation via inhibition of oxidative phosphorylation, which was crucial for intestinal glucose transport.
[Journal of Cellular and Molecular Medicine]
Zhao, L., Xuan, Z., Song, W., Zhang, S., Li, Z., Song, G., Zhu, X., Xie, H., Zheng, S., & Song, P. (n.d.). A novel role for farnesoid X receptor in the bile acid-mediated intestinal glucose homeostasis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15881 Cite
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Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection in Vitro

The authors suggest differential ability of specific Human Milk Oligosaccharides(HMOs) in modulating the intestinal barrier and support the potential of supplementation with combinations of available HMOs to promote gut health and protect against intestinal inflammatory disorders.
[Nutrients]
Natividad, J. M., Rytz, A., Keddani, S., Bergonzelli, G., & Garcia-Rodenas, C. L. (2020). Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection in Vitro. Nutrients, 12(10), 3047. https://doi.org/10.3390/nu12103047 Cite
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Long Noncoding RNA RP11-757g1.5 Sponges miR-139-5p and Upregulates YAP1 Thereby Promoting the Proliferation and Liver, Spleen Metastasis of Colorectal Cancer

Bioinformatics binding site analysis, Luciferase reporter assay, Ago2 immunoprecipitation assays, RNA pull-down assay, RT-qPCR and Western blotting were utilized to demonstrate that mechanism of RP11-757G1.5 acts as a molecular sponge of miR-139-5p to regulate the expression of YAP1.
[Journal of Experimental & Clinical Cancer Research]
Health, S. (n.d.). FDA authorizes new IND to evaluate impact of multi-strain probiotic DS-01TM on gut microbiota of patients with IBS. Retrieved October 8, 2020, from https://www.prnewswire.com/news-releases/fda-authorizes-new-ind-to-evaluate-impact-of-multi-strain-probiotic-ds-01-on-gut-microbiota-of-patients-with-ibs-301139955.html Cite
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