Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
Barnett, A. M., Mullaney, J. A., Hendriks, C., Le Borgne, L., McNabb, W. C., & Roy, N. (2021). Porcine colonoids and enteroids keep the memory of their origin during regeneration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00420.2020 Cite
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The Murine Intestinal Stem Cells Are Highly Sensitive to the Modulation of the T3/TRα1-Dependent Pathway

By using ex vivo 3D organoid cultures and molecular approaches scientists observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
[Development]
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Nevé, C. L., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. Development. https://doi.org/10.1242/dev.194357 Cite
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METTL3-Mediated m6a Methylation of SPHK2 Promotes Gastric Cancer Progression by Targeting KLF2

Quantitative real-time PCR, western blot and immunohistochemistry were utilized to detect the expression profiles and prognostic significance of SPHK2 in gastric cancer.
[Oncogene]
Huo, F.-C., Zhu, Z.-M., Zhu, W.-T., Du, Q.-Y., Liang, J., & Mou, J. (2021). METTL3-mediated m 6 A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. Oncogene, 1–14. https://doi.org/10.1038/s41388-021-01753-1 Cite
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Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway

Scientists investigated whether luteolin exhibits its anticancer effects by induction of apoptosis and autophagy in a p53-dependent manner in colon cancer cells.
[Nutrition and Cancer-An International Journal]
Yoo, H. S., Won, S. B., & Kwon, Y. H. (2021). Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway. Nutrition and Cancer, 0(0), 1–10. https://doi.org/10.1080/01635581.2021.1903947 Cite
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The Role of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer

Neoadjuvant therapy is becoming the standard of care for an increasing number of tumor types. Currently, colon cancer patients are still routinely treated with up-front surgery, and neoadjuvant systemic therapy is not yet standard.
[Cancer Management and Research]
Body, A., Prenen, H., Latham, S., Lam, M., Tipping-Smith, S., Raghunath, A., & Segelov, E. (2021). <p>The Role of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer</p>. Cancer Management and Research, 13, 2567–2579. https://doi.org/10.2147/CMAR.S262870 Cite
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Cancer Stem Cells in Colorectal Cancer and the Association with Chemotherapy Resistance

The characteristic surface markers of cancer stem cells and the related mechanism of drug resistance are discussed in detail by the authors.
[Medical Oncology]
Lei, X., He, Q., Li, Z., Zou, Q., Xu, P., Yu, H., Ding, Y., & Zhu, W. (2021). Cancer stem cells in colorectal cancer and the association with chemotherapy resistance. Medical Oncology, 38(4), 43. https://doi.org/10.1007/s12032-021-01488-9 Cite
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CircFAM73A Promotes the Cancer Stem Cell-Like Properties of Gastric Cancer through the miR-490-3p/HMGA2 Positive Feedback Loop and HNRNPK-Mediated β-Catenin Stabilization

The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
Xia, Y., Lv, J., Jiang, T., Li, B., Li, Y., He, Z., Xuan, Z., Sun, G., Wang, S., Li, Z., Wang, W., Wang, L., & Xu, Z. (2021). CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization. Journal of Experimental & Clinical Cancer Research, 40(1), 103. https://doi.org/10.1186/s13046-021-01896-9 Cite
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Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy

The authors studied the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations and explored the effect of increased MSI1 levels in response to treatment.
[Cancer Research]
Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Neve, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., Fouchardière, C. de la, & Plateroti, M. (2021). Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2450 Cite
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FTO-Mediated Cytoplasmic m6Am Demethylation Adjusts Stem-Like Properties in Colorectal Cancer Cell

Researchers showed that the cytoplasmic pool of fat mass and obesity-associated protein impeded cancer stem cellabilities in colorectal cancer through its N6,2’-O-dimethyladenosine (m6Am) demethylase activity.
[Nature Communications]
Relier, S., Ripoll, J., Guillorit, H., Amalric, A., Achour, C., Boissière, F., Vialaret, J., Attina, A., Debart, F., Choquet, A., Macari, F., Marchand, V., Motorin, Y., Samalin, E., Vasseur, J.-J., Pannequin, J., Aguilo, F., Lopez-Crapez, E., Hirtz, C., … David, A. (2021). FTO-mediated cytoplasmic m 6 A m demethylation adjusts stem-like properties in colorectal cancer cell. Nature Communications, 12(1), 1716. https://doi.org/10.1038/s41467-021-21758-4 Cite
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CXCL8 Chemokine in Ulcerative Colitis

The authors analyzed the CXCL8-CXCR1/2 axis related signaling pathways and ncRNAs in ulcerative colitis (UC), as well as recent advances in our understanding of the CXCL8-CXCR1/2 axis inhibition as a therapeutic strategy against UC.
[Biomedicine & Pharmacotherapy]
Zhu, Y., Yang, S., Zhao, N., Liu, C., Zhang, F., Guo, Y., & Liu, H. (2021). CXCL8 chemokine in ulcerative colitis. Biomedicine & Pharmacotherapy, 138, 111427. https://doi.org/10.1016/j.biopha.2021.111427 Cite
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Anti-Cancer Effects of Polyphenol-Rich Sugarcane Extract

Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
[PLoS One]
Prakash, M. D., Stojanovska, L., Feehan, J., Nurgali, K., Donald, E. L., Plebanski, M., Flavel, M., Kitchen, B., & Apostolopoulos, V. (2021). Anti-cancer effects of polyphenol-rich sugarcane extract. PLOS ONE, 16(3), e0247492. https://doi.org/10.1371/journal.pone.0247492 Cite
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