Therapeutic Targeting of SLC6A8 Creatine Transporter Suppresses Colon Cancer Progression and Modulates Human Creatine Levels

Scientists reported that RGX-202, an oral small-molecule SLC6A8 transporter inhibitor, robustly inhibited creatine import in vitro and in vivo, reduced intracellular phosphocreatine and ATP levels, and induced tumor apoptosis.
[Science Advances]
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Interferon B Drives Intestinal Regeneration after Radiation

Researchers reported that cGAS-STING–dependent type 1 interferon response drove intestinal regeneration and animal recovery from radiation injury.
[Science Advances]
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CRISPR Screens Identify Cholesterol Biosynthesis as a Therapeutic Target on Stemness and Drug Resistance of Colon Cancer

To identify genetic vulnerabilities of colon cancer, investigators performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon cancer stem cells-enriched spheroids.
[Oncogene]
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Mitochondrial and Glycolytic Extracellular Flux Analysis Optimization for Isolated Pig Intestinal Epithelial Cells

The authors developed a method to isolate viable intestinal epithelial cells, suitable to faithfully measure their metabolic function by determining extracellular glycolytic and mitochondrial flux.
[Scientific Reports]
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AHA1 Regulates Cell Migration and Invasion via the EMT Pathway in Colorectal Adenocarcinomas

To investigate how AHA1 expression regulated the cancer cell progression and/or metastasis of human colorectal cancer (CRC), the expression levels of AHA1 and Hsp90 were examined in 105 CRC tissue samples and compared with those in paired normal tissue.
[Scientific Reports]
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The Interaction of Helicobacter pylori with Cancer Immunomodulatory Stromal Cells: New Insight into Gastric Cancer Pathogenesis

The authors discuss the interplay between H. pylori and tumor-supportive cells, including mesenchymal stem cells, cancer-associated fibroblasts, tumor-associated macrophages, and myeloid derived-suppressor cells in gastric cancer.
[Seminars in Cancer Biology]
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Novocure and Zai Lab Announce Last Patient Enrolled in Phase 2 Pilot Trial of Tumor Treating Fields plus Chemotherapy as First-Line Treatment in Gastric Cancer in China

Novocure and Zai Lab Limited announced that the final patient has been enrolled in a Novocure-sponsored Phase II pilot trial conducted by Zai Lab evaluating the safety and efficacy of Tumor Treating Fields in combination with chemotherapy as a first-line treatment in patients with gastric adenocarcinoma.
[Novocure]
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CD127+ CD94+ Innate Lymphoid Cells Expressing Granulysin and Perforin Are Expanded in Patients with Crohn’s Disease

The authors analyzed CD127+ innate lymphoid cells (ILCs) and natural killer cells in intestinal lamina propria from healthy donors and Crohn’s disease patients and identified two populations of CD127+CD94+ ILCs, designated population A and B, that could be distinguished on the expression of CD117, CD18 and cytotoxic molecules.
[Nature Communications]
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BET Protein Degradation Triggers DR5-Mediated Immunogenic Cell Death to Suppress Colorectal Cancer and Potentiate Immune Checkpoint Blockade

Researchers found that inducing the degradation of bromodomain and extra-terminal domain (BET) proteins by the proteolysis targeting chimeras approach potently suppressed the growth of colorectal cancer including patient-derived tumors.
[Oncogene]
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ECHS1, an Interacting Protein of LASP1, Induces Sphingolipid-Metabolism Imbalance to Promote Colorectal Cancer Progression by Regulating Ceramide Glycosylation

Through an LC–MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer.
[Cell Death & Disease]
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ZNF545 Loss Promotes Ribosome Biogenesis and Protein Translation to Initiate Colorectal Tumorigenesis in Mice

The authors investigated the functional and molecular mechanism of Zinc finger protein 545 (ZNF545), a transcriptional repressor for ribosomal RNA, in colorectal cancer (CRC). ZNF545 was silenced in CRC compared to adjacent normal tissues, implying a tumor-suppressive role.
[Oncogene]
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