The solid lipid nanoparticle(SLN)-loaded 5-FU was developed by utilizing a Strategic and unique Method to Advance and Refine the Treatment of colorectal cancer through hot and cold homogenization approach. The SLN was made of unique PEGylated lipids and combination of the surfactants.
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Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer | Scientific Reports. (n.d.). Retrieved October 15, 2020, from https://www.nature.com/articles/s41598-020-73218-6 Cite
Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
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LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
Researchers investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
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Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
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In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
[Cell Death & Disease]
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B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 6, 2020, from https://www.nature.com/articles/s41419-020-03041-4 Cite
In this study, two flavonols galangin and kaempferol were heated at 100°C for 30 min prior to assessing their effects on barrier function of rat intestinal epithelial (IEC-6) cells.
[Journal of Nutritional Biochemistry]
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Fan, J., Zhao, X.-H., & Li, T.-J. (2020). Heat treatment of galangin and kaempferol inhibits their benefits to improve barrier function in rat intestinal epithelial cells: Galangin & kaempferol improve IEC-6 cells barrier function. The Journal of Nutritional Biochemistry, 108517. https://doi.org/10.1016/j.jnutbio.2020.108517 Cite
Using pharmacological and genetic perturbations in cultured intestinal epithelial cells, investigators found that non-muscle myosin-2C controls the length of growing microvilli by regulating actin turnover in a manner that requires a fully active motor domain.
[Molecular Biology of the Cell]
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Bile acid‐activated farnesoid X receptor enhanced glucose uptake in intestinal epithelial cells by increasing the expression of glucose transporter 2, which depended on ERK1/2 phosphorylation via S1PR2. However, it also reduced the cell energy generation via inhibition of oxidative phosphorylation, which was crucial for intestinal glucose transport.
[Journal of Cellular and Molecular Medicine]
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The authors suggest differential ability of specific Human Milk Oligosaccharides(HMOs) in modulating the intestinal barrier and support the potential of supplementation with combinations of available HMOs to promote gut health and protect against intestinal inflammatory disorders.
Bioinformatics binding site analysis, Luciferase reporter assay, Ago2 immunoprecipitation assays, RNA pull-down assay, RT-qPCR and Western blotting were utilized to demonstrate that mechanism of RP11-757G1.5 acts as a molecular sponge of miR-139-5p to regulate the expression of YAP1.
[Journal of Experimental & Clinical Cancer Research]
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Health, S. (n.d.). FDA authorizes new IND to evaluate impact of multi-strain probiotic DS-01TM on gut microbiota of patients with IBS. Retrieved October 8, 2020, from https://www.prnewswire.com/news-releases/fda-authorizes-new-ind-to-evaluate-impact-of-multi-strain-probiotic-ds-01-on-gut-microbiota-of-patients-with-ibs-301139955.html Cite