Wnt-Driven LARGE2 Mediates Laminin-Adhesive O-Glycosylation in Human Colonic Epithelial Cells and Colorectal Cancer

Investigators revealed that Wnt activity triggered the expression of the gene, LARGE2, which in turn mediated the laminin- adhesive O-glycosylation of α-DG. They found abnormally increased cellular adhesion to laminin during Wnt-driven cancer progression.
[Cell Communication and Signaling]
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MiR-200b in Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviates Inflammatory Injury of Intestinal Epithelial Cells by Targeting High Mobility Group Box 3

Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreases the inflammatory injury.
[Cell Death & Disease]
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Spermine Synthase and Myc Cooperate to Maintain Colorectal Cancer Cell Survival by Repressing Bim Expression

Researchers uncover a key survival signal in colorectal cancer through convergent repression of Bim expression by distinct SMS- and MYC-mediated signaling pathways.
[Nature Communications]
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Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Investigators demonstrated that the artificial sweeteners sucralose, aspartame, and saccharin exerted a range of negative effects on the intestinal epithelium through the sweet taste receptor T1R3.
[Nutrients]
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Ageing, Metabolism and the Intestine

Scientists review the current state of research of how metabolism and ageing control intestinal stem cell function and epithelial homeostasis.
[EMBO Reports]
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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