Salinomycin Inhibits Epigenetic Modulator EZH2 to Enhance Death Receptors in Colon Cancer Stem Cells

By harnessing cancer stem cell specific cytotoxic function of salinomycin, scientists discovered a critical role of epigenetic modulator EZH2 in regulating the expression of death receptors in colon cancer stem cells.
[Epigenetics]
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Open-Access Plan S to Allow Publishing in Any Journal

Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
[Nature News]
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During the Pandemic, Students Do Field and Lab Work without Leaving Home

Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
[Science Insider]
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An Analysis of Ways to Decarbonize Conference Travel after COVID-19

The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
[Nature News]
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Foreign Students in US: Trump Administration Drops Deportation Plans

US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC]
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Journals Endorse New Checklist to Clean Up Sloppy Animal Research

To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider]
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How Scientific Societies Are Weathering the Pandemic’s Financial Storm

As meetings worldwide have been called off, postponed or moved online because of the pandemic, organizations are trying to weather the cost of cancelling meetings while grappling with the long-term effects that the pandemic could have on their activities and on the research community.
[Nature]
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JS InnoPharm Announces First Patient Dosed with JSI-1187, a Selective ERK Inhibitor, in Phase I Clinical Study for Advanced Solid Tumors with MAPK Pathway Mutations

JS InnoPharm Ltd announced the enrollment of the first patient in a Phase I, open-label, monotherapy dose-escalation and expansion study of JSI-1187, the company’s lead investigational drug candidate targeting the enzymes ERK1 and ERK2.
[JS INNOPHARM LTD]
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The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer

Investigators demonstrated essential roles of ubiquitin-specific protease 25 in experimental colitis, bacterial infections and colon cancer.
[Nature Cancer]
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TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation

Researchers demonstrated that post-ionizing radiation overexpression of TIGAR, a critical downstream target of c-MYC in mouse intestine, mounted a hyperplastic response in Bmi1-creERT+ reserve ISCs, and thus rescued mice from lethal ionizing radiation exposure.
[Cell Death & Disease]
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Cancer-Associated Fibroblasts Mediate Cancer Progression and Remodel the Tumouroid Stroma

The authors supported, within a biomimetic 3D, in vitro framework, the direct role of cancer-associated fibroblasts in promoting cancer invasion, and their key function in driving vasculogenesis and angiogenesis.
[British Journal of Cancer]
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