Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells

Reasearchers showed that protein kinase C-ε promoted breast cancer cell survival not only by inhibiting apoptosis but also by inducing autophagy.
[International Journal of Molecular Sciences]
[zotpress items='{6606345:VQRME5R8}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Oncogene PRR14 Promotes Breast Cancer through Activation of pI3K Signal Pathway and Inhibition of CHEK2 Pathway

Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification.
[Cell Death & Disease]
[zotpress items='{6606345:EZ8U5GG4}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Antitumor Effect of a WEE1 Inhibitor and Potentiation of Olaparib Sensitivity by DNA Damage Response Modulation in Triple-Negative Breast Cancer

Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model.
[Scientific Reports]
[zotpress items='{6606345:3WSBRMYU}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Mitochondrial Dysfunction Generates Aggregates That Resist Lysosomal Degradation in Human Breast Cancer Cells

Researchers demonstrated protein aggregates and autophagy receptors, TAX1BP1 and NDP52, as potential endpoints for monitoring autophagy during drug development and clinical studies.
[Cell Death & Disease]
[zotpress items='{6606345:6BAVHYNE}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]
[zotpress items='{6606345:5MA2HR4P}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2- Early Breast Cancer

Eli Lilly and Company announced Verzenio® in combination with standard adjuvant endocrine therapy has met the primary endpoint of invasive disease-free survival, significantly decreasing the risk of breast cancer recurrence or death compared to standard adjuvant endocrine therapy alone.
[Lilly]
Press Release
Bookmark

No account yet? Register

Share

DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
[zotpress items='{6445212:C442AUVC}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Researchers showed that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients expressed higher levels of nuclear lysine specific demethylase 1 (LSD1) phosphorylated at serine 111 compared to responders, which is associated with co-expression of stem-like, mesenchymal genes.
[Frontiers in Immunology]
[zotpress items='{6445212:343FBF8F}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial
Bookmark

No account yet? Register

Share

Loss of ZIP Facilitates JAK2-STAT3 Activation in Tamoxifen-Resistant Breast Cancer

Scientists used a powerful validation-based insertion mutagenesis method to find that expression of a dominant-negative, truncated form of the histone deacetylase ZIP led to resistance to tamoxifen.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress items='{6606345:FMDDSFGB}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Snail Promotes the Generation of Vascular Endothelium by Breast Cancer Cells

Investigators reported a new and unexpected function of Snail in endothelium generation by breast cancer cells. They showed that high Snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

Share
Share