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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
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Pitavastatin Is a Novel Mcl-1 Inhibitor That Overcomes Paclitaxel Resistance in Triple-Negative Breast Cancer
[Experimental Hematology & Oncology] Researchers analyzed the impact of pitavastatin on TNBC cells was assessed in vitro by examining cell viability, apoptosis, mitochondrial function, and effects on cancer stem cell properties.
Genetic Regulation of the Estrogen Receptor and Inherited Predisposition to Breast Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Scientists evaluated 136 families for coinheritance of breast cancer with each of 79 common variants reported as high-confidence “risk alleles” for breast cancer by meta-analyses of genome-wide association studies.
BriaCell Announces Collaboration with MSK Accelerator to Advance Bria-OTS+™ for Breast Cancer
[BriaCell Therapeutics (BioSpace)] BriaCell Therapeutics announced a collaboration with Memorial Sloan Kettering Cancer Center’s Therapeutics Accelerator Cohort program to accelerate the clinical development of Bria-OTS+, BriaCell’s next generation personalized off-the-shelf immunotherapy, for multiple cancer indications including metastatic breast cancer, prostate cancer, and other cancers.
Damon Runyon Announces Newest Class of SPARK Scholars
[Damon Runyon] The Damon Runyon Cancer Research Foundation has named the newest cohort of the Damon Runyon Scholars Program for Advancing Research and Knowledge (SPARK), a one-year cancer research internship for post-baccalaureate scholars.
From Cold to Hot Tumors: Feasibility of Applying Therapeutic Insights to TNBC
[Discover Oncology] The authors summarize the biological characteristics of both cold and hot tumors and explore the mechanisms underlying the transformation from cold to hot tumors. Key strategies include modulation of the tumor microenvironment, enhancement of immune cell infiltration, and regulation of the inflammatory responses.
NRF2 Expression Level and Estrogen Function in BRCA1-Mutated Breast Cancer
[BMC Cancer] Scientists provide the first comprehensive analysis of NRF2 expression patterns in BRCA1-mutated breast tumors using clinically relevant formalin-fixed, paraffin-embedded samples, bridging a critical gap between experimental models and human patient data.
PARP1-Mediated PARylation of TEAD4 Stabilizes the YAP1-TEAD4 Complex and Promotes Growth and Immune Evasion in Breast Cancer Cells
[Science Signaling] Investigators found that the poly(ADP-ribose) polymerase PARP1 promotes the transcriptional activity of YAP1-TEAD4 complexes that mediate breast cancer cell stemness, metastatic behavior, and evasion of antitumor immunity.
Deubiquitinating Enzyme USP42 Promotes Breast Cancer Progression by Inhibiting JNK/P38-Mediated Apoptosis
[Scientific Reports] Scientists investigated the role of ubiquitin specific peptidase 42 (USP42) in breast cancer proliferation, focusing on its modulation of apoptosis via the JNK/p38 signaling pathway.
SIRT5-Mediated Desuccinylation of MTHFD2 Enhances Chemoresistance in Breast Cancer Cells by Reducing Therapy-Induced Senescence
[Communications Biology] Researchers found that low activity or depletion of MTHFD2 enhanced the degree of tumor cell senescence in breast cancer cells and decreases their resistance to chemotherapeutic agents.
Parity and Lactation Induce T Cell Mediated Breast Cancer Protection
[Nature] Investigators showed that parity induces an accumulation of CD8+ T cells, including cells with a tissue-resident memory-like phenotype within human normal breast tissue.
Synergistic Reduction of Breast Cancer Cell Viability and Aggressiveness through Dual Inhibition of APE1 Redox Function and STAT3 Signaling
[Cell Biology International] Scientists investigated the role of APE1 redox activity in the transcriptional activity of STAT3 and their crosstalk on proliferation, migration, and invasion processes in breast cancer cells.
Distinct and Convergent Effects of Mutations in Human Breast Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Characterization of the largest SF3B1 mutant breast cancer clinical cohort to date identifies SF3B1 driver mutations in approximately 2.5% of HR+ HER2- breast cancer, with strong enrichment of K700E substitution.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
