Comprehensive Multi-Omics Analysis Uncovers a Group of TGF-β-Regulated Genes among lncRNA EPR Direct Transcriptional Targets

Investigators integrated data derived from ChIRP-Seq, ChIP-Seq as well as RNA-Seq in a comprehensive analysis and selected a group of bona fide direct transcriptional targets of EPR. Among them, they identified a subset of EPR targets whose expression was controlled by TGF-β with one of them—Arrdc3—being able to modulate Epithelial to Mesenchymal Transition.
[Nucleic Acids Research]
Comprehensive multi-omics analysis uncovers a group of TGF-β-regulated genes among lncRNA EPR direct transcriptional targets | Nucleic Acids Research | Oxford Academic. (n.d.). Retrieved August 6, 2020, from https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa628/5881275 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
Sun, S., Chen, H., Sun, L., Wang, M., Wu, X., & Xiao, Z.-X. J. (2020). Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. Cell Death & Disease, 11(7), 1–9. https://doi.org/10.1038/s41419-020-02814-1 Cite
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Researchers demonstrated that hotspot mutant p53, p53-R273H, promoted cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a Zinc finger transcription factor and a documented tumor suppressor.
[Cell Death & Disease]
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S‐Adenosylmethionine in Combination with Decitabine Shows Enhanced Anti‐Cancer Effects in Repressing Breast Cancer Growth and Metastasis

Scientists investigated the combined therapeutic effects of an approved nutraceutical agent S‐adenosylmethionine and FDA‐approved hypomethylating agent decitabine using the MDA‐MB‐231 xenograft model of breast cancer and found a pronounced reduction in mammary tumour volume and lung metastasis compared to the animals in the control and monotherapy treatment arms.
[Journal of Cellular and Molecular Medicine]
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Histamine H4 Receptor Agonists Induce Epithelial-Mesenchymal Transition Events and Enhance Mammosphere Formation via Src and Tgf-β Signaling in Breast Cancer Cells

This study investigated the effects of H4R ligands on epithelial-mesenchymal transition and mammosphere formation as a surrogate assay for cancer stem cells in breast cancer cells with different invasive phenotype. They also investigated the participation of Src and TGF-β signaling in these events.
[Biochemical Pharmacology]
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24‐Dehydrocholesterol Reductase Promotes the Growth of Breast Cancer Stem‐like Cells through the Hedgehog Pathway

DHCR24 knockdown reduced whereas DHCR24 overexpression enhanced breast cancer stem‐like cell populations such as mammosphere and aldehyde dehydrogenase positive cell numbers. In addition, DHCR24 overexpression increased the expression of the Hedgehog pathway regulated genes.
[Cancer Science]
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Curcumin Inhibits the Growth of Triple‐Negative Breast Cancer Cells by Silencing ezh2 and Restoring DLC1 Expression

Researchers found that knockdown of enhancer of zeste homolog 2 (EZH2) expression restored the expression of deletion gene 1 (DLC1) and inhibited the migration, invasion and proliferation, promoted the apoptosis, and blocked the cell cycle of MDA‐MB‐231 cells.
[Journal of Cellular and Molecular Medicine]
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Henlius and Accord Healthcare Receive EMA Approval for Zercepac®, Trastuzumab Biosimilar

Shanghai Henlius Biotech, Inc. and Accord Healthcare Limited jointly announced the European Commission has approved Zercepac ® for the treatment of HER2-positive early breast cancer, HER2-positive metastatic breast cancer and HER2-positive metastatic gastric cancer.
[Henlius]
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MicroRNA‐Related Single‐Nucleotide Polymorphisms and Breast Cancer

The authors document the well‐known miR‐SNPs that are known to be associated with breast cancer. Two principals are discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.
[Journal of Cellular Physiology]
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Ribosomes as Nexus between Translation and Cancer Progression: Focus on Ribosomal RACK1 in Breast Cancer

Scientists provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal receptor for activated C kinase 1 (RACK1) in breast cancer.
[British Journal of Pharmacology]
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