Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.
[Cancer Cell International]
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Daiichi Sankyo Company, Limited and AstraZeneca announced that the first patient was dosed in DESTINY-Breast09, a phase III trial evaluating the safety and efficacy of ENHERTU® with or without pertuzumab compared to standard of care as a potential first-line treatment in patients with HER2 positive metastatic breast cancer.
[Daiichi Sankyo Company, Ltd]
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Using a previously established model of in vitro mineralization, the MDA-MB-231 human breast cancer cell line was induced using two osteogenic agents, inorganic phosphate and β-glycerophosphate, and direct monitoring of the mineralization process was conducted using Raman micro-spectroscopy.
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Scientists exploited cytokine-induced killer cells’ expression of FcγRIIIa in combination with clinical-grade monoclonal antibodies to redirect their lytic activity in an antigen-specific manner, and reported the efficacy of this combined approach against TNBC.
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A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
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Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.
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Circulating tumor cells enumeration at initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]
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The authors investigated the metabolic vulnerabilities of TNBC, particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics.
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Among 759 specimens, immunohistochemistry exhibited glycoprotein non-metastatic B (GPNMB) expressions were variable in different subtypes and significantly higher in TNBC. GPNMB positively correlated with epithelial–mesenchymal transition regulators, mesenchymal marker vimentin, MMP and integrins.
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DDR1 knockdown and DDR1 pharmacological inhibitor decreased cell growth and inhibited cell cycle progression in breast cancer cell lines, while enhanced the sensitivity of PIK3CA/AKT1 mutant cells to palbociclib.
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