Investigators showed that GALA induced the glycosylation of the ER-resident calnexin (Cnx) in breast and liver cancer. Glycosylated Cnx and its partner ERp57 are trafficked to invadosomes, which are sites of ECM degradation.
[Nature Cell Biology]
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Ros, M., Nguyen, A. T., Chia, J., Le Tran, S., Le Guezennec, X., McDowall, R., Vakhrushev, S., Clausen, H., Humphries, M. J., Saltel, F., & Bard, F. A. (2020). ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00590-w Cite
Gallic acid nanoparticles were evaluated for the in vitro cytotoxicity, cell uptake and cell migration in four types of human cancer cell lines including breast adenocarcinoma, HepG2 hepatocellular cancer, HT-29 colorectal adenocarcinoma, and MCF-10A breast epithelial cell lines.
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Single-cell RNA-seq performed on two different TNBC cell samples, infected or not with vaccinia virus, highlighted three distinct populations: naïve cells, bystander cells, defined as cells exposed to the virus but not infected and infected cells.
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Cambien, B., Lebrigand, K., Baeri, A., Nottet, N., Compin, C., Lamit, A., Ferraris, O., Peyrefitte, C. N., Magnone, V., Henriques, J., Zaragosi, L.-E., Giorgetti-Peraldi, S., Bost, F., Gautier-Isola, M., Rezzonico, R., Barbry, P., Barthel, R., Mari, B., & Vassaux, G. (2020). Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics. PLOS Pathogens, 16(10), e1008660. https://doi.org/10.1371/journal.ppat.1008660 Cite
Scientists utilized human tumor samples, cell culture models, and a mammary carcinoma mouse model with tissue-specific Rnf40 deletion and identified an unexpected tumor-supportive role of RNF40 in HER2-positive breast cancer subtype.
[Cell Death & Disease]
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By varying the physical properties of collagen, investigators found that MDA-MB-231 tumor cells invaded and escaped faster in lower-density ECM. These effects were mediated by the ECM pore size, rather than by the elastic modulus or interstitial flow speed.
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Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across triple negative breast cancer subtypes, prompting the implementation of biomarker-driven therapeutic approaches.
[npj breast cancer]
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Investigators found that active targeting nanoparticles displayed a superior DNA damage capability via enhanced-interactions with DNA and a significantly stronger effect in reducing cancer stem cell-like property of triple negative breast cancer cells, compared to conventional cisplatin and miriplatin.
[Journal of Controlled Release]
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Li, Y., Qian, D., Lin, H.-P., Xie, J., Yang, P., Maddy, D., Xiao, Y., Huang, X., Wang, Z., & Yang, C. (2020). Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2020.10.015 Cite
By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
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Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., Bedrosian, I., Mitsch, J., Quinlan, P., Thompson, A., Rajapakshe, K., Coarfa, C., Gunaratne, P. H., Marchion, D. C., Magliocco, A. M., Tsai, K. Y., & Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11(1), 5156. https://doi.org/10.1038/s41467-020-18973-w Cite
The authors discuss novel bispecific antibodies for TNBC and emerging TNBC targets for future bispecific antibody development.
[Trends in Cancer]
Investigators highlight various models of lymphatic metastasis, their potential pitfalls, and other tools available to study lymphatic metastasis including imaging modalities and -omic studies.
[Journal of Mammary Gland Biology and Neoplasia]
Savran Technologies Inc. announced the completion of an important Phase II multi-center clinical trial conducted at 20 sites across the country utilizing its unique detection platform.
[Savran Technologies Inc.(BusinessWire Inc.)]
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