The Long Non-Coding RNA ET-20 Mediates EMT by Impairing Desmosomes in Breast Cancer Cells

Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.
[Journal of Cell Science]
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MINDY1 Promotes Breast Cancer Cell Proliferation by Stabilizing Estrogen Receptor α

The authors identified MINDY1, a member belongs to the motif interacting with Ubcontaining novel DUB family (MINDY), as a potential deubiquitylase of estrogen receptor α in breast cancer.
[Cell Death & Disease]
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DRAIC Promotes Growth of Breast Cancer by Sponging miR-432-5p to Upregulate SLBP

Investigators conducted a qRT-PCR assay to measure the expression of downregulated RNA in cancer (DRAIC) and other downstream target genes. They uncovered that DRAIC was expressed at a high level in breast cancer cells.
[Cancer Gene Therapy]
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Sauchinone Inhibits the Proliferation, Migration and Invasion of Breast Cancer Cells by Suppressing Akt-CREB-MMP13 Signaling Pathway

Scientists investigated the effects of sauchinone on the growth of breast cancer cells along with the underlying molecular mechanisms. Their results showed that sauchinone treatment markedly inhibited the proliferation, migration, and invasion of breast cancer cells.
[Bioscience Reports]
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Surface-Tension-Induced Budding Drives Alveologenesis in Human Mammary Gland Organoids

Investigators demonstrated that epithelial gland morphogenesis was induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids.
[Nature Physics]
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RNA Binding Protein RBMS3 Is a Common EMT Effector That Modulates Triple-Negative Breast Cancer Progression via Stabilizing PRRX1 mRNA

Scientists identified RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) as a novel and common effector of epithelial-to-mesenchymal transition (EMT), which could be a promising therapeutic target for triple-negative breast cancer treatment.
[Oncogene]
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Transmembrane Protein 97 Exhibits Oncogenic Properties via Enhancing LRP6-Mediated Wnt Signaling in Breast Cancer

Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
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PEAK1 Promotes Invasion and Metastasis and Confers Drug Resistance in Breast Cancer

The authors investigated pseudopodium-enriched atypical kinase 1 (PEAK1) expression in breast cancer and its role in breast cancer cells in vitro and in vivo and analyzed the relationship with clinicopathological status and chemotherapy resistance.
[Clinical and Experimental Medicine]
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Emerging Role of Ferroptosis in Breast Cancer: New Dawn for Overcoming Tumor Progression

Investigators discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer and provide evidence that ferroptosis inducers eliminate breast cancer cells.
[Pharmacology & Therapeutics]
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Gilead Marks Fifth Approval for Trodelvy® in Metastatic Triple-Negative Breast Cancer Under Project Orbis Initiative with Health Canada Authorization

Gilead Sciences, Inc. announced that Health Canada has approved Trodelvy® for the treatment of adult patients with unresectable locally advanced or metastatic TNBC who have received two or more prior therapies, at least one of them for metastatic disease.
[Gilead Sciences, Inc.]
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Asymmetric Cell Division of Mammary Stem Cells

The authors discuss asymmetric cell division in breast/mammary stem cells and implications on further research, with focus on the role asymmetric cell division may play in breast cancer.
[Cell Division]
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