Targeting HER2+ Breast Cancer Brain Metastases: A Review of Brain-Directed HER2-Directed Therapies

HER2-targeted therapies, including antibody-drug conjugates, have presented new therapeutic options for this patient population; however, additional data for both small-molecule inhibitors and antibody-drug conjugates with respect to patients with central nervous system metastases is needed. Scientists specifically review the data for the management of HER2+ parenchymal brain metastases.
[CNS Drugs]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Syapse Extends Collaboration with Pfizer to Continue to Generate Real-World Evidence in Breast Cancer

Syapse® announced that Pfizer will continue working with Syapse to advance the use of real-world data from the Syapse Learning Health Network as an extension of the organizations’ ongoing collaboration. Syapse will maintain clinical abstractions resources to continue to grow the breast cancer data cohort, expand research questions that can be answered, and provide Pfizer with in-depth, aggregated insights.
[Syapse®]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Targeting CLK4 Inhibits the Metastasis and Progression of Breast Cancer by Inactivating TGF-β Pathway

Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal-like (MES-) TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.
[Cancer Gene Therapy]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Single-Cell Analysis of Somatic Mutation Burden in Mammary Epithelial Cells of Pathogenic BRCA1/2 Mutation Carriers

Investigators used an accurate, single-cell whole genome sequencing approach to first show that telomerized primary mammary epithelial cells heterozygous for a highly penetrant BRCA1 variant displayed a robustly elevated mutation frequency as compared to their isogenic control cells.
[Journal of Clinical Investigation]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Herceptin-Conjugated Magnetic Polystyrene-Agsbox Nanoparticles as a Theranostic Agent for Breast Cancer

Researchers demonstrated selective binding, effective uptake of herceptin (HER)-conjugated magnetic polystyrene-Agsbox nanoparticles into MDA-MB-231and SKBR-3 cell lines with no effect against L929.
[Journal of Biomaterials Applications]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Antiproliferative and Proapoptotic Activities of Sea Cucumber H. Leucospilota Extract on Breast Carcinoma Cell Line (SK-BR-3)

H. leucospilota was collected, the methanolic extract was prepared and in vitro cytotoxicity of H. leucospilota extract in the range of 12.5, 25, 50, 100, and 200 μg/mL concentrations for 48 hours on SK-BR-3 and MCR5 cells was determined.
[Molecular Biology Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

A Review of Prognostic and Predictive Biomarkers in Breast Cancer

By combining established prognostic factors with valid prognostic/predicted biomarkers, scientists can start the journey to personalized treatment for every recently diagnosed breast cancer patient.
[Clinical and Experimental Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Updates on Breast Biomarkers

The authors cover the evolution and latest updates of the CAP/ASCO guidelines relevant to these two important biomarkers in breast cancer.
[Virchows Archiv]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Autophagy Inhibits Cancer Stemness in Triple-Negative Breast Cancer via miR-181a-Mediated Regulation of ATG5 and/or ATG2B

The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.
[Molecular Oncology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Low Glucose-Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer

Researchers revealed a critical role for HOXC-AS3 in regulating the metabolic reprogramming of breast cancer cells under metabolic stress.
[Cancer Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

STAT3 Induces Breast Cancer Growth via ANGPTL4, MMP13 and STC1 Secretion by Cancer Associated Fibroblasts

Researchers demonstrated that STAT3 was essential for the pro-tumorigenic functions of murine breast cancer cancer associated fibroblasts both in vitro and in vivo, and identified a STAT3 signature significantly enriched for genes encoding for secreted proteins.
[Oncogene]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share