Utilizing the Hippo Pathway as a Therapeutic Target for Combating Endocrine-Resistant Breast Cancer

Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.
[Cancer Cell International]
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DESTINY-Breast09 Head-to-Head First-Line Phase 3 Trial of ENHERTU® Initiated in Patients with HER2 Positive Metastatic Breast Cancer

Daiichi Sankyo Company, Limited and AstraZeneca announced that the first patient was dosed in DESTINY-Breast09, a phase III trial evaluating the safety and efficacy of ENHERTU® with or without pertuzumab compared to standard of care as a potential first-line treatment in patients with HER2 positive metastatic breast cancer.
[Daiichi Sankyo Company, Ltd]
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A Time-Course Raman Spectroscopic Analysis of Spontaneous In Vitro Microcalcifications in a Breast Cancer Cell Line

Using a previously established model of in vitro mineralization, the MDA-MB-231 human breast cancer cell line was induced using two osteogenic agents, inorganic phosphate and β-glycerophosphate, and direct monitoring of the mineralization process was conducted using Raman micro-spectroscopy.
[Laboratory Investigation]
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Adoptive Cell Therapy of Triple Negative Breast Cancer with Redirected Cytokine-Induced Killer Cells

Scientists exploited cytokine-induced killer cells’ expression of FcγRIIIa in combination with clinical-grade monoclonal antibodies to redirect their lytic activity in an antigen-specific manner, and reported the efficacy of this combined approach against TNBC.
[Oncoimmunology]
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Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
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Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Biological Characteristics of a Sub-Population of Cancer Stem Cells from Two Triple-Negative Breast Tumor Cell Lines

The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.
[Heliyon]
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Circulating Tumor Cell Number and Endocrine Therapy Index in ER Positive Metastatic Breast Cancer Patients

Circulating tumor cells enumeration at initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]
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Metabolic Perturbations Sensitize Triple-Negative Breast Cancers to Apoptosis Induced by BH3 Mimetics

The authors investigated the metabolic vulnerabilities of TNBC, particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics.
[Science Signaling]
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Expression Pattern and Prognostic Impact of Glycoprotein Non-Metastatic B (GPNMB) in Triple-Negative Breast Cancer

Among 759 specimens, immunohistochemistry exhibited glycoprotein non-metastatic B (GPNMB) expressions were variable in different subtypes and significantly higher in TNBC. GPNMB positively correlated with epithelial–mesenchymal transition regulators, mesenchymal marker vimentin, MMP and integrins.
[Scientific Reports]
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Combined Inhibition of DDR1 and CDK4/6 Induces Synergistic Effects in ER-Positive, HER2-Negative Breast Cancer with PIK3CA/AKT1 Mutations

DDR1 knockdown and DDR1 pharmacological inhibitor decreased cell growth and inhibited cell cycle progression in breast cancer cell lines, while enhanced the sensitivity of PIK3CA/AKT1 mutant cells to palbociclib.
[Oncogene]
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