Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release via Small Extracellular Vesicles

By deleting an essential autophagy gene or disrupting its autophagy function, investigators determined a mechanism of HER2+ breast cancer tumorigenesis by directly regulating the oncogenic driver.
[Developmental Cell]
Hao, M., Yeo, S. K., Turner, K., Harold, A., Yang, Y., Zhang, X., & Guan, J.-L. (2021). Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.12.016 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

A Novel Hypoxic Long Noncoding RNA KB-1980E6.3 Maintains Breast Cancer Stem Cell Stemness via Interacting With IGF2BP1 to Facilitate C-Myc mRNA Stability

The enhanced long noncoding RNA KB-1980E6.3 facilitated breast cancer stem cells self-renewal and tumorigenesis under hypoxic microenvironment both in vitro and in vivo.
[Oncogene]
Zhu, P., He, F., Hou, Y., Tu, G., Li, Q., Jin, T., Zeng, H., Qin, Y., Wan, X., Qiao, Y., Qiu, Y., Teng, Y., & Liu, M. (2021). A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability. Oncogene, 1–19. https://doi.org/10.1038/s41388-020-01638-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

The Androgen Receptor Is a Tumor Suppressor in Estrogen Receptor–Positive Breast Cancer

Using a diverse, clinically relevant panel of cell-line and patient-derived models, the authors demonstrated that androgen receptor activation, not suppression, exerted potent antitumor activity in multiple disease contexts, including resistance to standard-of-care estrogen receptor and CDK4/6 inhibitors.
[Nature Medicine]
Hickey, T. E., Selth, L. A., Chia, K. M., Laven-Law, G., Milioli, H. H., Roden, D., Jindal, S., Hui, M., Finlay-Schultz, J., Ebrahimie, E., Birrell, S. N., Stelloo, S., Iggo, R., Alexandrou, S., Caldon, C. E., Abdel-Fatah, T. M., Ellis, I. O., Zwart, W., Palmieri, C., … Tilley, W. D. (2021). The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-01168-7 Cite
AbstractPress Release
Bookmark

No account yet? Register

0
Share

MEDAG Enhances Breast Cancer Progression and Reduces Epirubicin Sensitivity through the AKT/AMPK/mTOR Pathway

The authors found that the mesenteric estrogen-dependent adipogenesis gene (MEDAG) was highly expressed in breast cancer (BC) samples and that a high MEDAG expression was correlated with clinicopathological characteristics and poor survival in BC patients.
[Cell Death & Disease]
Li, Z., Li, C., Wu, Q., Tu, Y., Wang, C., Yu, X., Li, B., Wang, Z., Sun, S., & Sun, S. (2021). MEDAG enhances breast cancer progression and reduces epirubicin sensitivity through the AKT/AMPK/mTOR pathway. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-020-03340-w Cite
Full Article
Bookmark

No account yet? Register

0
Share

Overexpression of β-Arrestins Inhibits Proliferation and Motility in Triple Negative Breast Cancer Cells

Investigators examined the direct influence of β-arrestins on cellular function and gene expression profiles by changing their expression levels in breast cancer cells, MDA-MB-231 and MDA-MB-468.
[Scientific Reports]
Bostanabad, S. Y., Noyan, S., Dedeoglu, B. G., & Gurdal, H. (2021). Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells. Scientific Reports, 11(1), 1539. https://doi.org/10.1038/s41598-021-80974-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Decorin-Mediated Suppression of Tumorigenesis, Invasion, and Metastasis in Inflammatory Breast Cancer

Overexpression of decorin in inflammatory breast cancer (IBC) cells markedly decreased migration, invasion, and cancer stem cells in vitro and inhibited tumor growth and metastasis in IBC xenograft mouse models.
[Communications Biology]
Hu, X., Villodre, E. S., Larson, R., Rahal, O. M., Wang, X., Gong, Y., Song, J., Krishnamurthy, S., Ueno, N. T., Tripathy, D., Woodward, W. A., & Debeb, B. G. (2021). Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-020-01590-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Cathepsin C Promotes Breast Cancer Lung Metastasis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation

Scientists showed that tumor-secreted protease cathepsin C promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.
[Cancer Cell]
Xiao, Y., Cong, M., Li, J., He, D., Wu, Q., Tian, P., Wang, Y., Yang, S., Liang, C., Liang, Y., Wen, J., Liu, Y., Luo, W., Lv, X., He, Y., Cheng, D., Zhou, T., Zhao, W., Zhang, P., … Hu, G. (2021). Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.12.012 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Multiple Screening Approaches Reveal HDAC6 as a Novel Regulator of Glycolytic Metabolism in Triple-Negative Breast Cancer

Investigators set up a phenotypic small-molecule screen to reveal vulnerabilities in TNBC cells that were independent of mitochondrial apoptosis. Using a functional genetic approach, they identified that a “hit” compound, BAS-2, had a potentially similar mechanism of action to histone deacetylase inhibitors.
[Science Advances]
Dowling, C. M., Hollinshead, K. E. R., Grande, A. D., Pritchard, J., Zhang, H., Dillon, E. T., Haley, K., Papadopoulos, E., Mehta, A. K., Bleach, R., Lindner, A. U., Mooney, B., Düssmann, H., O’Connor, D., Prehn, J. H. M., Wynne, K., Hemann, M., Bradner, J. E., Kimmelman, A. C., … Chonghaile, T. N. (2021). Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science Advances, 7(3), eabc4897. https://doi.org/10.1126/sciadv.abc4897 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Isolation and Purification of Glycoglycerolipids To Induce Apoptosis in Breast Cancer Cells

Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
[Scientific Reports]
Abedin, M. R., & Barua, S. (2021). Isolation and purification of glycoglycerolipids to induce apoptosis in breast cancer cells. Scientific Reports, 11(1), 1298. https://doi.org/10.1038/s41598-020-80484-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Spliceosome-Targeted Therapies Trigger an Antiviral Immune Response in Triple-Negative Breast Cancer

Scientists discovered that mis-spliced RNA itself is a molecular trigger for tumor killing through viral mimicry. In MYC-driven TNBC, spliceosome-targeted therapies caused widespread cytoplasmic accumulation of mis-spliced mRNAs, many of which form double-stranded structures.
[Cell]
Bowling, E. A., Wang, J. H., Gong, F., Wu, W., Neill, N. J., Kim, I. S., Tyagi, S., Orellana, M., Kurley, S. J., Dominguez-Vidaña, R., Chung, H.-C., Hsu, T. Y.-T., Dubrulle, J., Saltzman, A. B., Li, H., Meena, J. K., Canlas, G. M., Chamakuri, S., Singh, S., … Westbrook, T. F. (2021). Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.12.031 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Interplay between Desmoglein2 and Hypoxia Controls Metastasis in Breast Cancer

Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
[Proceedings of the National Academy of Sciences of the United States of America]
Chang, P.-H., Chen, M.-C., Tsai, Y.-P., Tan, G. Y. T., Hsu, P.-H., Jeng, Y.-M., Tsai, Y.-F., Yang, M.-H., & Hwang-Verslues, W. W. (2021). Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2014408118 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share