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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Spatially Distinct Epithelial and Mesenchymal Cell Subsets Along Progressive Lineage Restriction in the Branching Embryonic Mammary Gland
[EMBO Journal] Using single-cell RNA sequencing, researchers produced an atlas of matched mouse mammary epithelium and mesenchyme and reconstructed the differentiation trajectories of multipotent stem cells toward basal and luminal fate.
A Functional Survey of the Regulatory Landscape of Estrogen-Receptor-Positive Breast Cancer Evolution
[Cancer Discovery] Scientists employed functional genomics to dissect the contribution of cis-regulatory elements (CREs) to cancer evolution. Parallel epigenetic perturbation in vitro revealed context-dependent roles for many CREs, with a specific impact on dormancy entrance and endocrine therapy resistance.
Plant-Derived Anti-Human Epidermal Growth Factor Receptor 2 Antibody Suppresses Trastuzumab-Resistant Breast Cancer With Enhanced Nanoscale Binding
[ACS Nano] A variety of biophysical techniques, in vitro assays, and in vivo experiments uncovered the plant-derived anti-human epidermal growth factor receptor 2 (HER2) antibody's nanoscale binding dynamics with transmembrane HER2 on living cells.
Epigenetic Activation of SOX11 is Associated with Recurrence and Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer
[British Journal Of Cancer] Human cell lines and mouse models of disease progression were analyzed for candidate risk predictive biomarkers identified and validated in two independent ductal carcinoma in situcohorts.
Sympathetic Nerve Signals: Orchestrators of Mammary Development and Stem Cell Vitality
[Journal Of Molecular Cell Biology] Using a mouse mammary gland model, investigators delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.
Resf1 Is a Compound G4 Quadruplex-Associated Tumor Suppressor for Triple Negative Breast Cancer
[PLOS Genetics] Researchers identified Resf1 as a novel metastasis susceptibility gene in ER- breast cancer. Reduction of Resf1 resulted in a significant increase in tumor growth, a shortened overall survival time, and increased incidence and number of lung metastases, consistent with patient data.
WDR61 Ablation Triggers R-Loop Accumulation and Suppresses Breast Cancer Progression
[FEBS Journal] Researchers elucidated the role of WDR61 in breast tumor development, and reported that knockdown of WDR61 compromised the proliferation of breast tumor cells with reduced colony-forming capacity.
A Comprehensive Overview of Metaplastic Breast Cancer: Features and Treatments
[Cancer Science] The authors provide a comprehensive review on the clinical features, molecular characteristics, invasion and metastasis patterns, and prognosis of metaplastic breast cancer, as well as recent advancements in treatment strategies.
The DRAP1/DR1 Repressor Complex Increases mTOR Activity to Promote Progression and Confer Everolimus Sensitivity in Triple-Negative Breast Cancer
[Cancer Research] Scientists identified upregulation of the transcriptional corepressor DRAP1 in TNBC, which was closely associated with poor recurrence-free survival in TNBC patients.
Phosphoglycerate Mutase 1 Promotes Breast Cancer Progression through Inducing Immunosuppressive M2 Macrophages
[Cancer Gene Therapy] Scientists reported that phosphoglycerate mutase 1 suppression in breast cancer cells led to a decrease in M2 polarization, migration, and interleukin-10 production of macrophages.
Intensity Therapeutics, Inc. and The Swiss Group for Clinical Cancer Research SAKK Sign a Collaboration Agreement to Conduct a Phase II Randomized, Clinical Trial...
[Intensity Therapeutics, Inc.] Intensity Therapeutics, Inc. announced that the company executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 followed by the standard of care (SOC) immuno/chemotherapy vs. SOC immune/chemotherapy alone in early-stage triple-negative breast cancer in 54 patients in Switzerland.
Continuous TNF-α Exposure in Mammary Epithelial Cells Promotes Cancer Phenotype Acquisition via EGFR/TNFR2 Activation
[Archives Of Pharmacal Research] The authors established MCF-10A cell lines incubated with TNF-α to investigate the effects of continuous TNF-α exposure on the phenotypic change of normal mammary epithelial cells.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
