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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long-Term Neuroprotection After Traumatic Brain Injury in Mice
[Advanced Science] Researchers demonstrated the neuroprotective effects of MSC-secretome treatment in traumatic brain injury and highlight prostaglandins and kynurenine as key mediators of this response.
A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis
[Advanced Science] The authors revealed that hematopoietic stem cells (HSCs) and MSCs within skeletal stem cells interact via a feedback loop: HSCs undergo premature senescence, leading to depletion of HSCs and secondary senescence of MSCs.
Integrative Analysis of Bulk and Single-Cell Gene Expression Profiles to Identify Bone Marrow Mesenchymal Cell Heterogeneity and Prognostic Significance in Multiple Myeloma
[Journal of Translational Medicine] Scientists investigated the heterogeneity of MSCs in multiple myeloma using single-cell RNA sequencing and bulk transcriptomic data.
Bone Mesenchymal Stem Cells Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis through REDD1/Autophagy Pathway
[Stem Cells Translational Medicine] Researchers provide preliminary evidence for the protective roles of bone marrow MSCs in liver fibrosis through regulated in development and DNA damage response 1 (REDD1)/autophagy pathway.
Heterogeneity of IL-15-Expressing Mesenchymal Stromal Cells Controls Natural Killer Cell Development and Immune Cell Homeostasis
[Nature Communications] Researchers used an Il15 knockin reporter and multiple conditional deletion mouse models to show distinct differences in IL-15 expression between bone marrow MSC subtypes.
The Role and Mechanism of Mesenchymal Stem Cells in Immunomodulation of Type 1 Diabetes Mellitus and Its Complications: Recent Research Progress and Challenges: A...
[Stem Cell Research & Therapy] Mesenchymal stem cells can treat type 1 diabetes through a variety of immune mechanisms and also play a positive role in the treatment of type 1 diabetes complications.
Isolation Methods of Exosomes Derived from Dental Stem Cells
[International Journal of Oral Science] Mesenchymal stem cells have been redefined as “medical signaling cells,” with their primary biological effects mediated through exosome secretion. Optimized isolation methods offer a path forward for overcoming current limitations and advancing the clinical use of exosome-based therapies.
Mesoblast Maintains Momentum With FDA on Accelerated Approval Pathway for Revascor® in Ischemic Heart Failure and Label Extension for Ryoncil® in Adults With GvHD
[Mesoblast] Mesoblast provided an update on continued momentum with US FDA regarding both accelerated approval pathway for Revascor® in the treatment of patients with ischemic chronic heart failure with reduced ejection fraction and inflammation, and label extension for Ryoncil® in adults with steroid refractory acute graft versus host disease.
Mesenchymal Stem Cell Transplantation Alleviated TBI-Induced Lung Injury by Inhibiting PAD4-Dependent NET Formation
[Journal of Advanced Research] Scientists investigated the therapeutic potential and mechanisms of human umbilical cord-derived MSCs transplantation for alleviating traumatic brain injury-induced lung injury and improving neurological function.
Senescence-Resistant Human Mesenchymal Progenitor Cells Counter Aging in Primates
[Cell] In a 44-week trial, scientists intravenously delivered senescence-resistant human mesenchymal progenitor cells to aged macaques, noting a systemic reduction in aging indicators, such as cellular senescence, chronic inflammation, and tissue degeneration, without any detected adverse effects.
Synergistic Potential of Bone Marrow Mesenchymal Stem Cells and mir181-A Combinational Therapy against Multiple Sclerosis
[Stem Cell Research & Therapy] Researchers proposed a synergistic therapy approach that combines the penetrative targeting capability of bone marrow MSCs (BMSCs) with the immuno-modulatory effects of miR181-a by overexpressing miR181-a to BMSCs through lentivirus packaging system.
CircRNA_1809 Promotes the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells through Mir-370-3p
[Scientific Reports] Investigators used gene knockdown/overexpression and siRNA transfection to evaluate the regulatory effects of circRNA_1809 on the miR-370-3p/Kitlg pathway and the osteogenic differentiation of rat bone marrow MSCs in vitro.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
